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10.1186_s40463-020-00460-3.pdf 1,97MB
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1000 Titel
  • Anterior skull base reconstruction using nasoseptal flap: Cadaveric feasibility study and clinical implication [SevEN-001]
1000 Autor/in
  1. Sung, Kyoung Su |
  2. Lim, Jaejoon |
  3. Na, Minkyun |
  4. Lee, Sanghun |
  5. Kim, Ju-Seong |
  6. Hong, Je Beom |
  7. Hong, Chang-Ki |
  8. Moon, Ju Hyung |
1000 Verlag
  • SAGE Publications
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-01-01
1000 Erschienen in
1000 Quellenangabe
  • 49(1)
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40463-020-00460-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504836/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:sec><jats:title>Background</jats:title><jats:p> Pedicled nasoseptal flap (PNSF) has significantly improved the surgical outcomes of endoscopic endonasal approach (EEAs) by reducing cerebrospinal fluid (CSF) leakage. The purpose of this study is to assess the feasibility of using a PNSF for anterior skull base (ASB) reconstruction and to describe a method to compensate for a short flap based on our results. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> In this cadaveric study, ASB dissection without sphenoidotomy was performed using 10 formalin-fixed and 5 fresh adult cadaver specimens, and the sufficiency of the PNSF to cover the ASB was assessed. After the sphenoidotomy, the length by which the PNSF fell short in providing coverage at the posterior wall of the frontal sinus (CPFS), and the extent of the anterior coverage from the limbus (CL) of the sphenoid bone was measured. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Without sphenoidotomy, the mean length of the remaining PNSF after the coverage of the posterior wall of the frontal sinus was 0.67 cm. After sphenoidotomy, the PNSF fell short by a mean length of 2.10 cm, in providing CPFS. The CL was 1.86 cm. Based on these findings, defects resulting from an endoscopic resection of ASB tumors were reconstructed using PNSF without total sphenoidotomy in 3 patients. There were no postoperative CSF leaks or complications. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> The use of PNSF for ASB reconstruction may be insufficient to cover the entire ASB defect after removal of large lesions which need total sphenoidotomy. When possible, by leaving some portion of the anterior sphenoid wall for supporting the PNSF, successful ASB reconstruction could be achieved in endoscopic resection of ASB tumors. Additional methods might be needed in some cases of large ASB lesions wherein the anterior sphenoid wall should be removed totally and the ASB defect is too large. </jats:p></jats:sec>
1000 Sacherschließung
lokal Anterior skull base
lokal Nasoseptal flap
lokal Sphenoid Bone/surgery [MeSH]
lokal Nose Neoplasms/diagnostic imaging [MeSH]
lokal Feasibility Studies [MeSH]
lokal Nose Neoplasms/surgery [MeSH]
lokal Magnetic Resonance Imaging [MeSH]
lokal Neuroblastoma/surgery [MeSH]
lokal Male [MeSH]
lokal Postoperative Complications/prevention
lokal Meningioma/surgery [MeSH]
lokal Original Research Article
lokal Cadaver [MeSH]
lokal Female [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Skull base reconstruction
lokal Middle Aged [MeSH]
lokal Cerebrospinal Fluid Leak/prevention
lokal Dissection [MeSH]
lokal Skull Base/surgery [MeSH]
lokal Skull Base Neoplasms/surgery [MeSH]
lokal Reconstructive Surgical Procedures/methods [MeSH]
lokal Neuroblastoma/diagnostic imaging [MeSH]
lokal Nasal Septum/transplantation [MeSH]
lokal Meningioma/diagnostic imaging [MeSH]
lokal Sphenoidotomy
lokal Surgical Flaps [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U3VuZywgS3lvdW5nIFN1|https://frl.publisso.de/adhoc/uri/TGltLCBKYWVqb29u|https://frl.publisso.de/adhoc/uri/TmEsIE1pbmt5dW4=|https://frl.publisso.de/adhoc/uri/TGVlLCBTYW5naHVu|https://frl.publisso.de/adhoc/uri/S2ltLCBKdS1TZW9uZw==|https://frl.publisso.de/adhoc/uri/SG9uZywgSmUgQmVvbQ==|https://frl.publisso.de/adhoc/uri/SG9uZywgQ2hhbmctS2k=|https://orcid.org/0000-0002-8925-5821
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