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1000 Titel
  • Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment
1000 Autor/in
  1. Zhang, Shenke |
  2. Ueno, Daishin |
  3. Ohira, Takashi |
  4. Kato, Hisashi |
  5. Izawa, Tetsuya |
  6. Yamanouchi, Sakuya |
  7. Yoshida, Yukari |
  8. Takahashi, Akihisa |
  9. Ohira, Yoshinobu |
1000 Verlag
  • Frontiers Media S.A.
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-26
1000 Erschienen in
1000 Quellenangabe
  • 9:707470
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-28
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fcell.2021.707470 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352372/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:p>The partial gravity environment in space can negatively affect bone health. This survey aimed to study the reaction of different parts of the lower limb bones of rats to partial gravity and the effects of different degrees of gravity on these bony parts. We used 15 8-week-old male Wistar Hannover rats were used at the beginning of the experiment. The degree of mechanical stress was modified, but the ankle joint was maintained at ∼30°, ∼120°, or ∼160° with or without plaster fixation during 10-day hindlimb suspension. Computed tomography was performed to measure the bone parameters [bone mineral density (BMD), trabecular BMD, cortical BMD, and cortical thickness] of each studied group of the whole, proximal, middle, and distal femur and distal tibia. BMD, trabecular BMD, and cortical thickness of the distal femur and proximal tibia of the simulated mechanical stress associated with partial gravity groups were significantly lower than those of the control group; the effect of different degrees of gravity on the same area of hindlimb bone had no significant difference. The simulated mechanical stress associated with partial gravity had the most significant effect on the bone close to the knee joint, with the largest weight-bearing response.</jats:p>
1000 Sacherschließung
lokal bone parameters
lokal distal femur
lokal partial gravity
lokal Cell and Developmental Biology
lokal proximal tibia
lokal simulated mechanical stress
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  1. https://frl.publisso.de/adhoc/uri/WmhhbmcsIFNoZW5rZQ==|https://frl.publisso.de/adhoc/uri/VWVubywgRGFpc2hpbg==|https://frl.publisso.de/adhoc/uri/T2hpcmEsIFRha2FzaGk=|https://frl.publisso.de/adhoc/uri/S2F0bywgSGlzYXNoaQ==|https://frl.publisso.de/adhoc/uri/SXphd2EsIFRldHN1eWE=|https://frl.publisso.de/adhoc/uri/WWFtYW5vdWNoaSwgU2FrdXlh|https://frl.publisso.de/adhoc/uri/WW9zaGlkYSwgWXVrYXJp|https://frl.publisso.de/adhoc/uri/VGFrYWhhc2hpLCBBa2loaXNh|https://frl.publisso.de/adhoc/uri/T2hpcmEsIFlvc2hpbm9idQ==
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