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1000 Titel
  • A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals
1000 Autor/in
  1. Lázaro, Jorge |
  2. Costanzo, Maria |
  3. Sanaki-Matsumiya, Marina |
  4. Girardot, Charles |
  5. Hayashi, Masafumi |
  6. Hayashi, Katsuhiko |
  7. Diecke, Sebastian |
  8. Hildebrandt, Thomas B. |
  9. Lazzari, Giovanna |
  10. Wu, Jun |
  11. Petkov, Stoyan |
  12. Behr, Rüdiger |
  13. Trivedi, Vikas |
  14. Matsuda, Mitsuhiro |
  15. Ebisuya, Miki |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-07-06
1000 Erschienen in
1000 Quellenangabe
  • 30(7):938-949.e7
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.stem.2023.05.014 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321541/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Differential speeds in biochemical reactions have been proposed to be responsible for the differences in developmental tempo between mice and humans. However, the underlying mechanism controlling the species-specific kinetics remains to be determined. Using in vitro differentiation of pluripotent stem cells, we recapitulated the segmentation clocks of diverse mammalian species varying in body weight and taxa: marmoset, rabbit, cattle, and rhinoceros. Together with mouse and human, the segmentation clock periods of the six species did not scale with the animal body weight, but with the embryogenesis length. The biochemical kinetics of the core clock gene HES7 displayed clear scaling with the species-specific segmentation clock period. However, the cellular metabolic rates did not show an evident correlation. Instead, genes involving biochemical reactions showed an expression pattern that scales with the segmentation clock period. Altogether, our stem cell zoo uncovered general scaling laws governing species-specific developmental tempo.
1000 Sacherschließung
lokal Mice [MeSH]
lokal Gene Expression Regulation, Developmental [MeSH]
lokal Biological Clocks [MeSH]
lokal Humans [MeSH]
lokal Cattle [MeSH]
lokal Rabbits [MeSH]
lokal Cell Differentiation [MeSH]
lokal Mammals/metabolism [MeSH]
lokal Animals [MeSH]
lokal Basic Helix-Loop-Helix Transcription Factors/metabolism [MeSH]
lokal Pluripotent Stem Cells [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TMOhemFybywgSm9yZ2U=|https://frl.publisso.de/adhoc/uri/Q29zdGFuem8sIE1hcmlh|https://frl.publisso.de/adhoc/uri/U2FuYWtpLU1hdHN1bWl5YSwgTWFyaW5h|https://frl.publisso.de/adhoc/uri/R2lyYXJkb3QsIENoYXJsZXM=|https://frl.publisso.de/adhoc/uri/SGF5YXNoaSwgTWFzYWZ1bWk=|https://frl.publisso.de/adhoc/uri/SGF5YXNoaSwgS2F0c3VoaWtv|https://frl.publisso.de/adhoc/uri/RGllY2tlLCBTZWJhc3RpYW4=|https://frl.publisso.de/adhoc/uri/SGlsZGVicmFuZHQsIFRob21hcyBCLg==|https://frl.publisso.de/adhoc/uri/TGF6emFyaSwgR2lvdmFubmE=|https://frl.publisso.de/adhoc/uri/V3UsIEp1bg==|https://frl.publisso.de/adhoc/uri/UGV0a292LCBTdG95YW4=|https://frl.publisso.de/adhoc/uri/QmVociwgUsO8ZGlnZXI=|https://frl.publisso.de/adhoc/uri/VHJpdmVkaSwgVmlrYXM=|https://frl.publisso.de/adhoc/uri/TWF0c3VkYSwgTWl0c3VoaXJv|https://orcid.org/0000-0003-1854-7496
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1000 Erstellt am 2024-05-28T16:08:52.310+0200
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