Modulation of the gut microbiome and Firmicutes phylum reduction by a nutraceutical blend in the obesity mouse model and overweight humans: A double-blind clinical trial

  1. Nehmi-Filho, Victor
  2. Freitas, Jessica Alves
  3. Franco, Lucas Augusto Moysés ORCID logo
  4. Martins, Roberta Cristina
  5. Turri, José Antônio Orellana
  6. Santamarina, Aline Boveto
  7. Fonseca, Joyce Vanessa da Silva
  8. Sabino, Ester Cerdeira
  9. Moraes, Bruna Carvalho
  10. Souza, Erica
  11. Murata, Gilson Masahiro
  12. Costa, Silvia Figueiredo
  13. Alcântara, Paulo Sérgio
  14. Otoch, José Pinhata
  15. Flavia Marcal Pessoa, Ana ORCID logo

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Food Science Nutrition - 2024 - Nehmi‐Filho - Modulation of the gut microbiome and Firmicutes phylum reduction by a.pdf 8,82MB
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1000 Titel
  • Modulation of the gut microbiome and Firmicutes phylum reduction by a nutraceutical blend in the obesity mouse model and overweight humans: A double-blind clinical trial
1000 Autor/in
  1. Nehmi-Filho, Victor |
  2. Freitas, Jessica Alves |
  3. Franco, Lucas Augusto Moysés |
  4. Martins, Roberta Cristina |
  5. Turri, José Antônio Orellana |
  6. Santamarina, Aline Boveto |
  7. Fonseca, Joyce Vanessa da Silva |
  8. Sabino, Ester Cerdeira |
  9. Moraes, Bruna Carvalho |
  10. Souza, Erica |
  11. Murata, Gilson Masahiro |
  12. Costa, Silvia Figueiredo |
  13. Alcântara, Paulo Sérgio |
  14. Otoch, José Pinhata |
  15. Flavia Marcal Pessoa, Ana |
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-01-19
1000 Erschienen in
1000 Quellenangabe
  • 12(4):2436-2454
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/fsn3.3927 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Overweight and obesity are closely linked to gut dysbiosis/dysmetabolism and disrupted De-Ritis ratio [aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio], which may contribute to chronic noncommunicable diseases onset. Concurrently, extensive research explores nutraceuticals, and health-enhancing supplements, for disease prevention or treatment. Thus, sedentary overweight volunteers were double-blind randomized into two groups: Novel Nutraceutical_(S) (without silymarin) and Novel Nutraceutical (with silymarin). Experimental formulations were orally administered twice daily over 180 consecutive days. We evaluated fecal gut microbiota, based on partial 16S rRNA sequences, biochemistry and endocrine markers, steatosis biomarker (AST/ALT ratio), and anthropometric parameters. Post-supplementation, only the Novel Nutraceutical group reduced Clostridium clostridioforme (Firmicutes), Firmicutes/Bacteroidetes ratio (F/B ratio), and De-Ritis ratio, while elevating Bacteroides caccae and Bacteroides uniformis (Bacteroidetes) in Brazilian sedentary overweight volunteers after 180 days. In summary, the results presented here allow us to suggest the gut microbiota as the action mechanism of the Novel Nutraceutical promoting metabolic hepatic recovery in obesity/overweight non-drug interventions.
1000 Sacherschließung
lokal gut microbiota
lokal prebiotics
lokal overweight
lokal silymarin
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TmVobWktRmlsaG8sIFZpY3Rvcg==|https://frl.publisso.de/adhoc/uri/RnJlaXRhcywgSmVzc2ljYSBBbHZlcw==|https://orcid.org/0000-0002-6034-920X|https://frl.publisso.de/adhoc/uri/TWFydGlucywgUm9iZXJ0YSBDcmlzdGluYQ==|https://frl.publisso.de/adhoc/uri/VHVycmksIEpvc8OpIEFudMO0bmlvIE9yZWxsYW5h|https://frl.publisso.de/adhoc/uri/U2FudGFtYXJpbmEsIEFsaW5lIEJvdmV0bw==|https://frl.publisso.de/adhoc/uri/Rm9uc2VjYSwgSm95Y2UgVmFuZXNzYSBkYSBTaWx2YQ==|https://frl.publisso.de/adhoc/uri/U2FiaW5vLCBFc3RlciBDZXJkZWlyYQ==|https://frl.publisso.de/adhoc/uri/TW9yYWVzLCBCcnVuYSBDYXJ2YWxobw==|https://frl.publisso.de/adhoc/uri/U291emEsIEVyaWNh|https://frl.publisso.de/adhoc/uri/TXVyYXRhLCBHaWxzb24gTWFzYWhpcm8=|https://frl.publisso.de/adhoc/uri/Q29zdGEsIFNpbHZpYSBGaWd1ZWlyZWRv|https://frl.publisso.de/adhoc/uri/QWxjw6JudGFyYSwgUGF1bG8gU8Opcmdpbw==|https://frl.publisso.de/adhoc/uri/T3RvY2gsIEpvc8OpIFBpbmhhdGE=|https://orcid.org/0000-0003-3979-1607
1000 Hinweis
  • This article also appears in: Health Implications of Dietary Fibers and Bioactive Carbohydrates from Natural Resources
1000 Label
1000 Förderer
  1. Efeom Nutrition S.A |
  2. Fundação de Amparo à Pesquisa do Estado de São Paulo |
  3. Financiadora de Estudos e Projetos |
  4. Conselho Nacional de Desenvolvimento Científico e Tecnológico |
  5. Bill and Melinda Gates Foundation |
  6. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
1000 Fördernummer
  1. 01/04–21
  2. 18/14389-0
  3. 01.20.0029.000462/20
  4. 404096/2020-4
  5. INV-034540
  6. 88887.703169/2022-00
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Efeom Nutrition S.A |
    1000 Förderprogramm -
    1000 Fördernummer 01/04–21
  2. 1000 joinedFunding-child
    1000 Förderer Fundação de Amparo à Pesquisa do Estado de São Paulo |
    1000 Förderprogramm -
    1000 Fördernummer 18/14389-0
  3. 1000 joinedFunding-child
    1000 Förderer Financiadora de Estudos e Projetos |
    1000 Förderprogramm -
    1000 Fördernummer 01.20.0029.000462/20
  4. 1000 joinedFunding-child
    1000 Förderer Conselho Nacional de Desenvolvimento Científico e Tecnológico |
    1000 Förderprogramm -
    1000 Fördernummer 404096/2020-4
  5. 1000 joinedFunding-child
    1000 Förderer Bill and Melinda Gates Foundation |
    1000 Förderprogramm -
    1000 Fördernummer INV-034540
  6. 1000 joinedFunding-child
    1000 Förderer Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
    1000 Förderprogramm -
    1000 Fördernummer 88887.703169/2022-00
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6483041.rdf
1000 Erstellt am 2024-06-11T13:16:00.802+0200
1000 Erstellt von 286
1000 beschreibt frl:6483041
1000 Bearbeitet von 286
1000 Zuletzt bearbeitet Tue Jun 11 13:19:27 CEST 2024
1000 Objekt bearb. Tue Jun 11 13:19:27 CEST 2024
1000 Vgl. frl:6483041
1000 Oai Id
  1. oai:frl.publisso.de:frl:6483041 |
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1000 Sichtbarkeit Daten public
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