Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe

  1. Horemheb-Rubio, Gibran
  2. Eggeling, Ralf
  3. Schmeiβer, Norbert
  4. Pfeifer, Nico
  5. Lengauer, Thomas
  6. Gärtner, Barbara C.
  7. Prifert, Christiane
  8. Kochanek, Matthias
  9. Scheid, Christoph
  10. Kaiser, Rolf
  11. C. Gärtner, Barbara
  12. Weissbrich, Benedikt
  13. Adams, Ortwin
  14. Berger, Annemarie
  15. Palupsky, Katrin
  16. Huzly, Daniela
  17. Tiemann, Carsten
  18. Borena, Wegene
  19. Lindauer, Andreas
  20. Liebert, Uwe Gerd
  21. Siemens, Hans-Joachim
  22. Hofmann, Jörg
  23. Eis-Hübinger, Anna-Maria
  24. Grundmann, Hajo
  25. Kehlen, Astrid
  26. Oehme, Albrecht
  27. Schnitzler, Paul
  28. Kühn, Joachim
  29. Heim, Albert
  30. Sauerbrei, Andreas
  31. Schmidt, Barbara
  32. Beck, Robert
  33. Hoffmann, Dieter
  34. Michel, Detlef
  35. Nitschko, Hans
  36. Aepinus, Christian
  37. Dreier, Jens
  38. Puchhammer-Stoeckl, Elisabeth
  39. Kaup, Theresa Popow
  40. Redlberger, Monika
  41. Kessler, Harald
  42. Obermeier, Martin
  43. Weise, Kerstin
  44. Bartsch, Patricia
  45. Devide, Annette
  46. Niesters, Bert
  47. Kleines, Michael
  48. Krumbholz, Andi
  49. Meyer, Thomas
  50. Gohl, Peter
  51. G. Schüttler, Christian
  52. Gorgievski, Meri
  53. Pagarolas, Andres Anton
  54. Gulich, Wolfgang
  55. Ziegler, Thomas
  56. Wintsche, Babett
  57. Griego, Marcena
  58. Bossart, Walter

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1000 Titel
  • Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe
1000 Autor/in
  1. Horemheb-Rubio, Gibran |
  2. Eggeling, Ralf |
  3. Schmeiβer, Norbert |
  4. Pfeifer, Nico |
  5. Lengauer, Thomas |
  6. Gärtner, Barbara C. |
  7. Prifert, Christiane |
  8. Kochanek, Matthias |
  9. Scheid, Christoph |
  10. Kaiser, Rolf |
  11. C. Gärtner, Barbara |
  12. Weissbrich, Benedikt |
  13. Adams, Ortwin |
  14. Berger, Annemarie |
  15. Palupsky, Katrin |
  16. Huzly, Daniela |
  17. Tiemann, Carsten |
  18. Borena, Wegene |
  19. Lindauer, Andreas |
  20. Liebert, Uwe Gerd |
  21. Siemens, Hans-Joachim |
  22. Hofmann, Jörg |
  23. Eis-Hübinger, Anna-Maria |
  24. Grundmann, Hajo |
  25. Kehlen, Astrid |
  26. Oehme, Albrecht |
  27. Schnitzler, Paul |
  28. Kühn, Joachim |
  29. Heim, Albert |
  30. Sauerbrei, Andreas |
  31. Schmidt, Barbara |
  32. Beck, Robert |
  33. Hoffmann, Dieter |
  34. Michel, Detlef |
  35. Nitschko, Hans |
  36. Aepinus, Christian |
  37. Dreier, Jens |
  38. Puchhammer-Stoeckl, Elisabeth |
  39. Kaup, Theresa Popow |
  40. Redlberger, Monika |
  41. Kessler, Harald |
  42. Obermeier, Martin |
  43. Weise, Kerstin |
  44. Bartsch, Patricia |
  45. Devide, Annette |
  46. Niesters, Bert |
  47. Kleines, Michael |
  48. Krumbholz, Andi |
  49. Meyer, Thomas |
  50. Gohl, Peter |
  51. G. Schüttler, Christian |
  52. Gorgievski, Meri |
  53. Pagarolas, Andres Anton |
  54. Gulich, Wolfgang |
  55. Ziegler, Thomas |
  56. Wintsche, Babett |
  57. Griego, Marcena |
  58. Bossart, Walter |
1000 Verlag
  • BioMed Central
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-06-11
1000 Erschienen in
1000 Quellenangabe
  • 22(1):1167
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12889-022-13555-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187845/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Lower respiratory tract infections are among the main causes of death. Although there are many respiratory viruses, diagnostic efforts are focused mainly on influenza. The Respiratory Viruses Network (RespVir) collects infection data, primarily from German university hospitals, for a high diversity of infections by respiratory pathogens. In this study, we computationally analysed a subset of the RespVir database, covering 217,150 samples tested for 17 different viral pathogens in the time span from 2010 to 2019.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We calculated the prevalence of 17 respiratory viruses, analysed their seasonality patterns using information-theoretic measures and agglomerative clustering, and analysed their propensity for dual infection using a new metric dubbed average coinfection exclusion score (ACES).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>After initial data pre-processing, we retained 206,814 samples, corresponding to 1,408,657 performed tests. We found that Influenza viruses were reported for almost the half of all infections and that they exhibited the highest degree of seasonality. Coinfections of viruses are frequent; the most prevalent coinfection was rhinovirus/bocavirus and most of the virus pairs had a positive ACES indicating a tendency to exclude each other regarding infection.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The analysis of respiratory viruses dynamics in monoinfection and coinfection contributes to the prevention, diagnostic, treatment, and development of new therapeutics. Data obtained from multiplex testing is fundamental for this analysis and should be prioritized over single pathogen testing.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Coinfection/epidemiology [MeSH]
lokal Respiratory Tract Infections [MeSH]
lokal Humans [MeSH]
lokal Respiratory viruses
lokal Rhinovirus [MeSH]
lokal Surveillance
lokal Coinfection
lokal Viral exclusion
lokal Medical and Health Sciences
lokal Infant [MeSH]
lokal Research
lokal Virus Diseases/epidemiology [MeSH]
lokal Viruses [MeSH]
lokal Seasonality
1000 Liste der Beteiligten
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