The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial

  1. Baldia, Philipp Heinrich
  2. Wernly, Bernhard
  3. Flaatten, Hans
  4. Fjølner, Jesper
  5. Artigas, Antonio
  6. Pinto, Bernardo Bollen
  7. Schefold, Joerg C.
  8. Kelm, Malte
  9. Beil, Michael
  10. Bruno, Raphael Romano
  11. Binnebößel, Stephan
  12. Wolff, Georg
  13. Erkens, Ralf
  14. Sigal, Sviri
  15. van Heerden, Peter Vernon
  16. Szczeklik, Wojciech
  17. Elhadi, Muhammed
  18. Oeyen, Sandra
  19. Marsh, Brian
  20. Andersen, Finn H.
  21. Moreno, Rui
  22. Leaver, Susannah
  23. De Lange, Dylan W.
  24. Guidet, Bertrand
  25. Eller, Philipp
  26. Joannidis, Michael
  27. Mesotten, Dieter
  28. Reper, Pascal
  29. Swinnen, Walter
  30. Serck, Nicolas
  31. DEWAELE, ELISABETH
  32. Brix, Helene
  33. Brushoej, Jens
  34. Kumar, Pritpal
  35. Nedergaard, Helene Korvenius
  36. Balleby, Ida Riise
  37. Bundesen, Camilla
  38. Hansen, Maria Aagaard
  39. Uhrenholt, Stine
  40. Bundgaard, Helle
  41. Innes, Richard
  42. Gooch, James
  43. Cagova, Lenka
  44. Potter, Elizabeth
  45. Reay, Michael
  46. Davey, Miriam
  47. Abusayed, Mohammed Abdelshafy
  48. Humphreys, Sally
  49. Galbois, Arnaud
  50. Charron, Cyril
  51. Berlemont, Caroline Hauw
  52. Besch, Guillaume
  53. Rigaud, Jean-Philippe
  54. Maizel, Julien
  55. Djibré, Michel
  56. Burtin, Philippe
  57. Garcon, Pierre
  58. Nseir, Saad
  59. Valette, Xavier
  60. Alexandru, Nica
  61. Marin, Nathalie
  62. Vaissiere, Marie
  63. PLANTEFEVE, Gaëtan
  64. Vanderlinden, Thierry
  65. Jurcisin, Igor
  66. Megarbane, Buno
  67. Chousterman, Benjamin Glenn
  68. Dépret, François
  69. Garnier, Marc
  70. Besset, Sebastien
  71. Oziel, Johanna
  72. Ferre, Alexis
  73. Dauger, Stéphane
  74. Dumas, Guillaume
  75. Goncalves, Bruno
  76. Vettoretti, Lucie
  77. Thevenin, Didier
  78. Kurt, Muhammed
  79. Faltlhauser, Andreas
  80. Milovanovic, Milena
  81. Lutz, Matthias
  82. Shala, Gonxhe
  83. Haake, Hendrik
  84. Randerath, Winfried
  85. Kunstein, Anselm
  86. Meybohm, Patrick
  87. Schaller, Stefan
  88. Steiner, Stephan
  89. Barth, Eberhard
  90. Poerner, Tudor
  91. Simon, Philipp
  92. Lorenz, Marco
  93. Dindane, Zouhir
  94. Kuhn, Karl Friedrich
  95. Welte, Martin
  96. Voigt, Ingo
  97. Kabitz, Hans-Joachim
  98. Wollborn, Jakob
  99. Goebel, Ulrich
  100. Stoll, Sandra Emily
  101. Kindgen-Milles, Detlef
  102. Dubler, Simon
  103. Jung, Christian
  104. Fuest, Kristina
  105. Schuster, Michael
  106. Papadogoulas, Antonios
  107. Mulita, Francesk
  108. Rovina, Nikoletta
  109. Aidoni, Zoi
  110. CHRISANTHOPOULOU, EVANGELIA
  111. KONDILI, EUMORFIA
  112. Andrianopoulos, Ioannis
  113. Groenendijk, Martijn
  114. Evers, Mirjam
  115. van Lelyveld-Haas, Lenneke
  116. Meynaar, Iwan
  117. Cornet, Alexander Daniel
  118. Zegers, Marieke
  119. Dieperink, Willem
  120. de Lange, Dylan
  121. Dormans, Tom
  122. Hahn, Michael
  123. Sjøbøe, Britt
  124. Strietzel, Hans Frank
  125. Olasveengen, Theresa
  126. Romundstad, Luis
  127. Kluzik, Anna
  128. Zatorski, Paweł
  129. Drygalski, Tomasz
  130. Klimkiewicz, Jakub
  131. Solek-pastuszka, Joanna
  132. Onichimowski, Dariusz
  133. Czuczwar, Miroslaw
  134. Gawda, Ryszard
  135. Stefaniak, Jan
  136. Stefanska-Wronka, Karina
  137. Zabul, Ewa
  138. Oliveira, Ana Isabel Pinho
  139. Assis, Rui
  140. de Lurdes Campos Santos, Maria
  141. Santos, Henrique
  142. Cardoso, Filipe Sousa
  143. Gordinho, André
  144. Banzo, MJosé Arche
  145. Zalba-Etayo, Bego��a
  146. CUBERO, PATRICIA JIMENO
  147. Priego, Jesús
  148. Gomà, Gemma
  149. Tomasa-Irriguible, Teresa Maria
  150. Sancho, Susana
  151. Ferreira, Aida Fernández
  152. Vázquez, Eric Mayor
  153. Mira, Ángela Prado
  154. Ibarz, Mercedes
  155. Iglesias, David
  156. Arias-Rivera, Susana
  157. Frutos-Vivar, Fernando
  158. Lopez-Cuenca, Sonia
  159. Aldecoa, Cesar
  160. Perez-Torres, David
  161. Canas-Perez, Isabel
  162. Tamayo-Lomas, Luis
  163. Diaz-Rodriguez, Cristina
  164. de Gopegui, Pablo Ruiz
  165. Ben-Hamouda, Nawfel
  166. Roberti, Andrea
  167. Fleury, Yvan
  168. Abidi, Nour
  169. Dullenkopf, Alexander
  170. Pugh, Richard
  171. Smuts, Sara

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1000 Titel
  • The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial
1000 Autor/in
  1. Baldia, Philipp Heinrich |
  2. Wernly, Bernhard |
  3. Flaatten, Hans |
  4. Fjølner, Jesper |
  5. Artigas, Antonio |
  6. Pinto, Bernardo Bollen |
  7. Schefold, Joerg C. |
  8. Kelm, Malte |
  9. Beil, Michael |
  10. Bruno, Raphael Romano |
  11. Binnebößel, Stephan |
  12. Wolff, Georg |
  13. Erkens, Ralf |
  14. Sigal, Sviri |
  15. van Heerden, Peter Vernon |
  16. Szczeklik, Wojciech |
  17. Elhadi, Muhammed |
  18. Oeyen, Sandra |
  19. Marsh, Brian |
  20. Andersen, Finn H. |
  21. Moreno, Rui |
  22. Leaver, Susannah |
  23. De Lange, Dylan W. |
  24. Guidet, Bertrand |
  25. Eller, Philipp |
  26. Joannidis, Michael |
  27. Mesotten, Dieter |
  28. Reper, Pascal |
  29. Swinnen, Walter |
  30. Serck, Nicolas |
  31. DEWAELE, ELISABETH |
  32. Brix, Helene |
  33. Brushoej, Jens |
  34. Kumar, Pritpal |
  35. Nedergaard, Helene Korvenius |
  36. Balleby, Ida Riise |
  37. Bundesen, Camilla |
  38. Hansen, Maria Aagaard |
  39. Uhrenholt, Stine |
  40. Bundgaard, Helle |
  41. Innes, Richard |
  42. Gooch, James |
  43. Cagova, Lenka |
  44. Potter, Elizabeth |
  45. Reay, Michael |
  46. Davey, Miriam |
  47. Abusayed, Mohammed Abdelshafy |
  48. Humphreys, Sally |
  49. Galbois, Arnaud |
  50. Charron, Cyril |
  51. Berlemont, Caroline Hauw |
  52. Besch, Guillaume |
  53. Rigaud, Jean-Philippe |
  54. Maizel, Julien |
  55. Djibré, Michel |
  56. Burtin, Philippe |
  57. Garcon, Pierre |
  58. Nseir, Saad |
  59. Valette, Xavier |
  60. Alexandru, Nica |
  61. Marin, Nathalie |
  62. Vaissiere, Marie |
  63. PLANTEFEVE, Gaëtan |
  64. Vanderlinden, Thierry |
  65. Jurcisin, Igor |
  66. Megarbane, Buno |
  67. Chousterman, Benjamin Glenn |
  68. Dépret, François |
  69. Garnier, Marc |
  70. Besset, Sebastien |
  71. Oziel, Johanna |
  72. Ferre, Alexis |
  73. Dauger, Stéphane |
  74. Dumas, Guillaume |
  75. Goncalves, Bruno |
  76. Vettoretti, Lucie |
  77. Thevenin, Didier |
  78. Kurt, Muhammed |
  79. Faltlhauser, Andreas |
  80. Milovanovic, Milena |
  81. Lutz, Matthias |
  82. Shala, Gonxhe |
  83. Haake, Hendrik |
  84. Randerath, Winfried |
  85. Kunstein, Anselm |
  86. Meybohm, Patrick |
  87. Schaller, Stefan |
  88. Steiner, Stephan |
  89. Barth, Eberhard |
  90. Poerner, Tudor |
  91. Simon, Philipp |
  92. Lorenz, Marco |
  93. Dindane, Zouhir |
  94. Kuhn, Karl Friedrich |
  95. Welte, Martin |
  96. Voigt, Ingo |
  97. Kabitz, Hans-Joachim |
  98. Wollborn, Jakob |
  99. Goebel, Ulrich |
  100. Stoll, Sandra Emily |
  101. Kindgen-Milles, Detlef |
  102. Dubler, Simon |
  103. Jung, Christian |
  104. Fuest, Kristina |
  105. Schuster, Michael |
  106. Papadogoulas, Antonios |
  107. Mulita, Francesk |
  108. Rovina, Nikoletta |
  109. Aidoni, Zoi |
  110. CHRISANTHOPOULOU, EVANGELIA |
  111. KONDILI, EUMORFIA |
  112. Andrianopoulos, Ioannis |
  113. Groenendijk, Martijn |
  114. Evers, Mirjam |
  115. van Lelyveld-Haas, Lenneke |
  116. Meynaar, Iwan |
  117. Cornet, Alexander Daniel |
  118. Zegers, Marieke |
  119. Dieperink, Willem |
  120. de Lange, Dylan |
  121. Dormans, Tom |
  122. Hahn, Michael |
  123. Sjøbøe, Britt |
  124. Strietzel, Hans Frank |
  125. Olasveengen, Theresa |
  126. Romundstad, Luis |
  127. Kluzik, Anna |
  128. Zatorski, Paweł |
  129. Drygalski, Tomasz |
  130. Klimkiewicz, Jakub |
  131. Solek-pastuszka, Joanna |
  132. Onichimowski, Dariusz |
  133. Czuczwar, Miroslaw |
  134. Gawda, Ryszard |
  135. Stefaniak, Jan |
  136. Stefanska-Wronka, Karina |
  137. Zabul, Ewa |
  138. Oliveira, Ana Isabel Pinho |
  139. Assis, Rui |
  140. de Lurdes Campos Santos, Maria |
  141. Santos, Henrique |
  142. Cardoso, Filipe Sousa |
  143. Gordinho, André |
  144. Banzo, MJosé Arche |
  145. Zalba-Etayo, Bego��a |
  146. CUBERO, PATRICIA JIMENO |
  147. Priego, Jesús |
  148. Gomà, Gemma |
  149. Tomasa-Irriguible, Teresa Maria |
  150. Sancho, Susana |
  151. Ferreira, Aida Fernández |
  152. Vázquez, Eric Mayor |
  153. Mira, Ángela Prado |
  154. Ibarz, Mercedes |
  155. Iglesias, David |
  156. Arias-Rivera, Susana |
  157. Frutos-Vivar, Fernando |
  158. Lopez-Cuenca, Sonia |
  159. Aldecoa, Cesar |
  160. Perez-Torres, David |
  161. Canas-Perez, Isabel |
  162. Tamayo-Lomas, Luis |
  163. Diaz-Rodriguez, Cristina |
  164. de Gopegui, Pablo Ruiz |
  165. Ben-Hamouda, Nawfel |
  166. Roberti, Andrea |
  167. Fleury, Yvan |
  168. Abidi, Nour |
  169. Dullenkopf, Alexander |
  170. Pugh, Richard |
  171. Smuts, Sara |
1000 Verlag
  • BioMed Central
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-12-27
1000 Erschienen in
1000 Quellenangabe
  • 22(1):1000
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12877-022-03709-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794407/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>In the early COVID-19 pandemic concerns about the correct choice of analgesics in patients with COVID-19 were raised. Little data was available on potential usefulness or harmfulness of prescription free analgesics, such as paracetamol. This international multicentre study addresses that lack of evidence regarding the usefulness or potential harm of paracetamol intake prior to ICU admission in a setting of COVID-19 disease within a large, prospectively enrolled cohort of critically ill and frail intensive care unit (ICU) patients.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This prospective international observation study (The COVIP study) recruited ICU patients ≥ 70 years admitted with COVID-19. Data on Sequential Organ Failure Assessment (SOFA) score, prior paracetamol intake within 10 days before admission, ICU therapy, limitations of care and survival during the ICU stay, at 30 days, and 3 months. Paracetamol intake was analysed for associations with ICU-, 30-day- and 3-month-mortality using Kaplan Meier analysis. Furthermore, sensitivity analyses were used to stratify 30-day-mortality in subgroups for patient-specific characteristics using logistic regression.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>44% of the 2,646 patients with data recorded regarding paracetamol intake within 10 days prior to ICU admission took paracetamol. There was no difference in age between patients with and without paracetamol intake. Patients taking paracetamol suffered from more co-morbidities, namely diabetes mellitus (43% versus 34%, <jats:italic>p</jats:italic> &lt; 0.001), arterial hypertension (70% versus 65%, <jats:italic>p</jats:italic> = 0.006) and had a higher score on Clinical Frailty Scale (CFS; IQR 2–5 versus IQR 2–4, <jats:italic>p</jats:italic> &lt; 0.001). Patients under prior paracetamol treatment were less often subjected to intubation and vasopressor use, compared to patients without paracetamol intake (65 versus 71%, <jats:italic>p</jats:italic> &lt; 0.001; 63 versus 69%, <jats:italic>p</jats:italic> = 0.007). Paracetamol intake was not associated with ICU-, 30-day- and 3-month-mortality, remaining true after multivariate adjusted analysis.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Paracetamol intake prior to ICU admission was not associated with short-term and 3-month mortality in old, critically ill intensive care patients suffering from COVID-19.</jats:p> <jats:p>Trial registration.</jats:p> <jats:p>This prospective international multicentre study was registered on ClinicalTrials.gov with the identifier “NCT04321265” on March 25, 2020. </jats:p> </jats:sec>
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Medical and Health Sciences
lokal Paracetamol
lokal Research
lokal ICU
lokal Frailty
lokal COVID-19
lokal Analgesics
1000 Liste der Beteiligten
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1000 Hinweis
  • DeepGreen-ID: 6ef2028286654d428b0d7ef0f40139cc ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6485880.rdf
1000 Erstellt am 2024-10-02T22:49:39.529+0200
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1000 Zuletzt bearbeitet 2024-10-04T17:35:36.876+0200
1000 Objekt bearb. Fri Oct 04 17:35:36 CEST 2024
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