A Retrospective Analysis of Biliary Tract Cancer Patients Presented to the Molecular Tumor Board at the Comprehensive Cancer Center Munich

  1. Zhang, Danmei
  2. Dorman, Klara
  3. Heinrich, Kathrin
  4. Weiss, Lena
  5. Boukovala, Myrto
  6. Haas, Michael
  7. Greif, Philipp A.
  8. Ziemann, Frank
  9. Beyer, Georg
  10. Roessler, Daniel
  11. Goni, Elisabetta
  12. Renz, Bernhard
  13. D’Haese, Jan G.
  14. Kunz, Wolfgang G.
  15. Seidensticker, Max
  16. Corradini, Stefanie
  17. Niyazi, Maximilian
  18. Ormanns, Steffen
  19. Kumbrink, Jörg
  20. Jung, Andreas
  21. Mock, Andreas
  22. Rudelius, Martina
  23. Klauschen, Frederick
  24. Werner, Jens
  25. Mayerle, Julia
  26. von Bergwelt-Baildon, Michael
  27. Boeck, Stefan
  28. Heinemann, Volker
  29. Westphalen, Benedikt ORCID logo

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1000 Titel
  • A Retrospective Analysis of Biliary Tract Cancer Patients Presented to the Molecular Tumor Board at the Comprehensive Cancer Center Munich
1000 Autor/in
  1. Zhang, Danmei |
  2. Dorman, Klara |
  3. Heinrich, Kathrin |
  4. Weiss, Lena |
  5. Boukovala, Myrto |
  6. Haas, Michael |
  7. Greif, Philipp A. |
  8. Ziemann, Frank |
  9. Beyer, Georg |
  10. Roessler, Daniel |
  11. Goni, Elisabetta |
  12. Renz, Bernhard |
  13. D’Haese, Jan G. |
  14. Kunz, Wolfgang G. |
  15. Seidensticker, Max |
  16. Corradini, Stefanie |
  17. Niyazi, Maximilian |
  18. Ormanns, Steffen |
  19. Kumbrink, Jörg |
  20. Jung, Andreas |
  21. Mock, Andreas |
  22. Rudelius, Martina |
  23. Klauschen, Frederick |
  24. Werner, Jens |
  25. Mayerle, Julia |
  26. von Bergwelt-Baildon, Michael |
  27. Boeck, Stefan |
  28. Heinemann, Volker |
  29. Westphalen, Benedikt |
1000 Verlag
  • Springer International Publishing
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-08-18
1000 Erschienen in
1000 Quellenangabe
  • 18(5):767-776
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11523-023-00985-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517894/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background and objective!#!With the rising importance of precision oncology in biliary tract cancer (BTC), the aim of this retrospective single-center analysis was to describe the clinical and molecular characteristics of patients with BTC who underwent comprehensive genomic profiling (CGP) and were discussed in the CCCMunich!##!Patients and methods!#!In this single-center observational study, we included BTC patients with intrahepatic cholangiocarcinoma (iCCA), extrahepatic CCA (eCCA), and gallbladder cancer (GB), who had been discussed in the institutional MTB from May 29, 2017, to July 25, 2022. Patients were followed up until 31 January 2023. Data were retrospectively collected by review of medical charts, and MTB recommendation.!##!Results!#!In total, 153 cases were registered to the MTB with a median follow-up of 15 months. Testing was successful in 81.7% of the patients. CGP detected targetable alterations in 35.3% of our BTC patients (most commonly ARID1A/ERBB2/IDH1/PIK3CA/BRAF-mutations and FGFR2-fusions). Recommendations for molecularly guided therapy were given in 46.4%. Of those, treatment implementation of targeted therapy followed in 19.4%. In patients receiving the recommended treatment, response rate was 57% and median overall survival was 19 months (vs 8 months in the untreated cohort). The progression-free survival ratio of 1.45 suggest a clinical benefit of molecularly guided treatment.!##!Conclusions!#!In line with previous work, our series demonstrates feasibility and clinical utility of comprehensive genomic profiling in BTC patients. With the growing number of targeted agents with clinical activity in BTC, CGP should become standard of care in the management of this group of patients.
1000 Sacherschließung
lokal Medical and Health Sciences
lokal Bile Ducts, Intrahepatic/pathology [MeSH]
lokal Biliary Tract Neoplasms/pathology [MeSH]
lokal Humans [MeSH]
lokal Original Research Article
lokal Retrospective Studies [MeSH]
lokal Bile Duct Neoplasms/pathology [MeSH]
lokal Precision Medicine [MeSH]
lokal Biliary Tract Neoplasms/therapy [MeSH]
lokal Biliary Tract Neoplasms/genetics [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2024-10-02T23:22:06.401+0200
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