A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients

  1. Pazan, Farhad
  2. Petrovic, Mirko
  3. Cherubini, Antonio
  4. Cruz-Jentoft, Alfonso J.
  5. Denkinger, Michael
  6. van der Cammen, Tischa J. M.
  7. Stevenson, Jennifer M.
  8. Ibrahim, Kinda
  9. Rajkumar, Chakravarthi
  10. Bakken, Marit Stordal
  11. Crome, Peter
  12. Guðmundsson, Adalsteinn
  13. Knol, Wilma
  14. Snijders, Birgitta M. G.
  15. O�Mahony, Denis
  16. Serra-Rexach, José Antonio
  17. Soulis, George
  18. van Marum, Rob J.
  19. Ziere, Gijsbertus
  20. Mair, Alpana
  21. Burkhardt, Heinrich
  22. Neumann-Podczaska, Agnieszka
  23. Wieczorowska-Tobis, Katarzyna
  24. Fernandes, Marilia Andreia
  25. Gruner, Heidi
  26. van der Velde, Nathalie
  27. Wehling, Martin

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1000 Titel
  • A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients
1000 Autor/in
  1. Pazan, Farhad |
  2. Petrovic, Mirko |
  3. Cherubini, Antonio |
  4. Cruz-Jentoft, Alfonso J. |
  5. Denkinger, Michael |
  6. van der Cammen, Tischa J. M. |
  7. Stevenson, Jennifer M. |
  8. Ibrahim, Kinda |
  9. Rajkumar, Chakravarthi |
  10. Bakken, Marit Stordal |
  11. Crome, Peter |
  12. Guðmundsson, Adalsteinn |
  13. Knol, Wilma |
  14. Snijders, Birgitta M. G. |
  15. O�Mahony, Denis |
  16. Serra-Rexach, José Antonio |
  17. Soulis, George |
  18. van Marum, Rob J. |
  19. Ziere, Gijsbertus |
  20. Mair, Alpana |
  21. Burkhardt, Heinrich |
  22. Neumann-Podczaska, Agnieszka |
  23. Wieczorowska-Tobis, Katarzyna |
  24. Fernandes, Marilia Andreia |
  25. Gruner, Heidi |
  26. van der Velde, Nathalie |
  27. Wehling, Martin |
1000 Verlag
  • Springer International Publishing
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-10-26
1000 Erschienen in
1000 Quellenangabe
  • 39(11):863-874
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s40266-022-00980-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626423/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Cognitive decline is common in older people. Numerous studies point to the detrimental impact of polypharmacy and inappropriate medication on older people's cognitive function. Here we aim to systematically review evidence on the impact of medication optimisation and drug interventions on cognitive function in older adults.!##!Methods!#!A systematic review was performed using MEDLINE and Web of Science on May 2021. Only randomised controlled trials (RCTs) addressing the impact of medication optimisation or pharmacological interventions on quantitative measures of cognitive function in older adults (aged > 65 years) were included. Single-drug interventions (e.g., on drugs for dementia) were excluded. The quality of the studies was assessed by using the Jadad score.!##!Results!#!Thirteen studies met the inclusion criteria. In five studies a positive impact of the intervention on metric measures of cognitive function was observed. Only one study showed a significant improvement of cognitive function by medication optimisation. The remaining four positive studies tested methylphenidate, selective oestrogen receptor modulators, folic acid and antipsychotics. The mean Jadad score was low (2.7).!##!Conclusion!#!This systematic review identified a small number of heterogenous RCTs investigating the impact of medication optimisation or pharmacological interventions on cognitive function. Five trials showed a positive impact on at least one aspect of cognitive function, with comprehensive medication optimisation not being more successful than focused drug interventions. More prospective trials are needed to specifically assess ways of limiting the negative impact of certain medication in particular and polypharmacy in general on cognitive function in older patients.
1000 Sacherschließung
lokal Antipsychotic Agents [MeSH]
lokal Systematic Review
lokal Randomized Controlled Trials as Topic [MeSH]
lokal Medical and Health Sciences
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Cognitive Dysfunction [MeSH]
lokal Polypharmacy [MeSH]
lokal Cognition [MeSH]
1000 Liste der Beteiligten
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