Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study

  1. Wolff, Georg ORCID logo
  2. Wernly, Bernhard
  3. Flaatten, Hans
  4. Fjølner, Jesper
  5. Bruno, Raphael Romano
  6. Artigas, Antonio
  7. Pinto, Bernardo Bollen
  8. Schefold, Joerg C.
  9. Kelm, Malte
  10. Binneboessel, Stephan
  11. Baldia, Philipp
  12. Beil, Michael
  13. Sivri, Sigal
  14. van Heerden, Peter Vernon
  15. Szczeklik, Wojciech
  16. Elhadi, Muhammed
  17. Joannidis, Michael
  18. Oeyen, Sandra
  19. Flamm, Maria
  20. Zafeiridis, Tilemachos
  21. Marsh, Brian
  22. Andersen, Finn H.
  23. Moreno, Rui
  24. Boumendil, Ariane
  25. De Lange, Dylan W.
  26. Guidet, Bertrand
  27. Leaver, Susannah
  28. Jung, Christian ORCID logo
  29. the COVIP Study Group

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1000 Titel
  • Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study
1000 Titelzusatz
  • Caractéristiques des traitements en fonction du sexe et résultats de mortalité à 30 jours des patients atteints de COVID-19 gravement malades de plus de 70 ans—résultats de l’étude prospective COVIP
1000 Autor/in
  1. Wolff, Georg |
  2. Wernly, Bernhard |
  3. Flaatten, Hans |
  4. Fjølner, Jesper |
  5. Bruno, Raphael Romano |
  6. Artigas, Antonio |
  7. Pinto, Bernardo Bollen |
  8. Schefold, Joerg C. |
  9. Kelm, Malte |
  10. Binneboessel, Stephan |
  11. Baldia, Philipp |
  12. Beil, Michael |
  13. Sivri, Sigal |
  14. van Heerden, Peter Vernon |
  15. Szczeklik, Wojciech |
  16. Elhadi, Muhammed |
  17. Joannidis, Michael |
  18. Oeyen, Sandra |
  19. Flamm, Maria |
  20. Zafeiridis, Tilemachos |
  21. Marsh, Brian |
  22. Andersen, Finn H. |
  23. Moreno, Rui |
  24. Boumendil, Ariane |
  25. De Lange, Dylan W. |
  26. Guidet, Bertrand |
  27. Leaver, Susannah |
  28. Jung, Christian |
  29. the COVIP Study Group |
1000 Verlag Springer International Publishing
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-08-09
1000 Erschienen in
1000 Quellenangabe
  • 69(11):1390-1398
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s12630-022-02304-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363137/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific differences in treatment and outcome after intensive care unit (ICU) admission in this cohort.!##!Methods!#!We performed a sex-specific analysis in critically ill patients ≥ 70 yr of age with COVID-19 who were included in the international prospective multicenter COVIP study. All patients were analyzed for ICU admission and treatment characteristics. We performed a multilevel adjusted regression analysis to elucidate associations of sex with 30-day mortality.!##!Results!#!A total of 3,159 patients (69.8% male, 30.2% female; median age, 75 yr) were included. Male patients were significantly fitter than female patients as determined by the Clinical Frailty Scale (fit, 67% vs 54%; vulnerable, 14% vs 19%; frail, 19% vs 27%; P < 0.001). Male patients more often underwent tracheostomy (20% vs 14%; odds ratio [OR], 1.57; P < 0.001), vasopressor therapy (69% vs 62%; OR, 1.25; P = 0.02), and renal replacement therapy (17% vs 11%; OR, 1.96; P < 0.001). There was no difference in mechanical ventilation, life-sustaining treatment limitations, and crude 30-day mortality (50% male vs 49% female; OR, 1.11; P = 0.19), which remained true after adjustment for disease severity, frailty, age and treatment limitations (OR, 1.17; 95% confidence interval, 0.94 to 1.45; P = 0.16).!##!Conclusion!#!In this analysis of sex-specific treatment characteristics and 30-day mortality outcomes of critically ill patients with COVID-19 ≥ 70 yr of age, we found more tracheostomy and renal replacement therapy in male vs female patients, but no significant association of patient sex with 30-day mortality.!##!Study registration!#!www.!##!Clinicaltrials!#!gov (NCT04321265); registered 25 March 2020).
1000 Sacherschließung
lokal critical illness
gnd 1206347392 COVID-19
lokal Female [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal mortality
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Critical Care Medicine
lokal Reports of Original Investigations
lokal COVID-19
lokal COVID
lokal COVID-19/therapy [MeSH]
lokal Frailty [MeSH]
lokal Pandemics [MeSH]
lokal Critical Illness [MeSH]
lokal COVIP
lokal Medical and Health Sciences
lokal Male [MeSH]
lokal Intensive Care Units [MeSH]
lokal elderly
lokal sex
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1734-6177|https://frl.publisso.de/adhoc/uri/V2Vybmx5LCBCZXJuaGFyZA==|https://frl.publisso.de/adhoc/uri/RmxhYXR0ZW4sIEhhbnM=|https://frl.publisso.de/adhoc/uri/RmrDuGxuZXIsIEplc3Blcg==|https://frl.publisso.de/adhoc/uri/QnJ1bm8sIFJhcGhhZWwgUm9tYW5v|https://frl.publisso.de/adhoc/uri/QXJ0aWdhcywgQW50b25pbw==|https://frl.publisso.de/adhoc/uri/UGludG8sIEJlcm5hcmRvIEJvbGxlbg==|https://frl.publisso.de/adhoc/uri/U2NoZWZvbGQsIEpvZXJnIEMu|https://frl.publisso.de/adhoc/uri/S2VsbSwgTWFsdGU=|https://frl.publisso.de/adhoc/uri/QmlubmVib2Vzc2VsLCBTdGVwaGFu|https://frl.publisso.de/adhoc/uri/QmFsZGlhLCBQaGlsaXBw|https://frl.publisso.de/adhoc/uri/QmVpbCwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/U2l2cmksIFNpZ2Fs|https://frl.publisso.de/adhoc/uri/dmFuIEhlZXJkZW4sIFBldGVyIFZlcm5vbg==|https://frl.publisso.de/adhoc/uri/U3pjemVrbGlrLCBXb2pjaWVjaA==|https://frl.publisso.de/adhoc/uri/RWxoYWRpLCBNdWhhbW1lZA==|https://frl.publisso.de/adhoc/uri/Sm9hbm5pZGlzLCBNaWNoYWVs|https://frl.publisso.de/adhoc/uri/T2V5ZW4sIFNhbmRyYQ==|https://frl.publisso.de/adhoc/uri/RmxhbW0sIE1hcmlh|https://frl.publisso.de/adhoc/uri/WmFmZWlyaWRpcywgVGlsZW1hY2hvcw==|https://frl.publisso.de/adhoc/uri/TWFyc2gsIEJyaWFu|https://frl.publisso.de/adhoc/uri/QW5kZXJzZW4sIEZpbm4gSC4=|https://frl.publisso.de/adhoc/uri/TW9yZW5vLCBSdWk=|https://frl.publisso.de/adhoc/uri/Qm91bWVuZGlsLCBBcmlhbmU=|https://frl.publisso.de/adhoc/uri/RGUgTGFuZ2UsIER5bGFuIFcu|https://frl.publisso.de/adhoc/uri/R3VpZGV0LCBCZXJ0cmFuZA==|https://frl.publisso.de/adhoc/uri/TGVhdmVyLCBTdXNhbm5haA==|https://orcid.org/0000-0001-8325-250X|https://frl.publisso.de/adhoc/uri/dGhlIENPVklQIFN0dWR5IEdyb3Vw
1000 Hinweis
  • DeepGreen-ID: 8d33815174184a748f112ce4a21575c7 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. Assistance Publique - Hôpitaux de Paris |
  2. Norway health region west |
  3. H2020 European Research Council |
  4. Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf |
  5. Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts |
1000 Fördernummer
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    1000 Förderer Assistance Publique - Hôpitaux de Paris |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Norway health region west |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer H2020 European Research Council |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 Erstellt am 2024-10-03T08:32:21.803+0200
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