Hypoglycemic and hypolipidemic effects of Lippia origanoides Kunth in diabetic rats

  1. Miranda, Vinicius Carvalho
  2. Pereira, Yago ORCID logo
  3. Santos da Paz, Allane Patricia ORCID logo
  4. Rodrigues de Souza, Keyla ORCID logo
  5. Cristina Freitas da Silva, Márcia ORCID logo
  6. Muto, Nilton ORCID logo
  7. Romano Monteiro, Patrick ORCID logo
  8. Santos, Agenor ORCID logo
  9. Hamoy, Moises ORCID logo
  10. MEDEIROS CARVALHO, MARIA DAS GRACAS FREIRE DE ORCID logo
  11. Souza do Carmo, Iolanda ORCID logo
  12. Silva, Maria Eduarda Moraes
  13. de Sousa Lima Neto, José ORCID logo
  14. Joia de Mello, Vanessa ORCID logo

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WeightNameValue
1000 Titel
  • Hypoglycemic and hypolipidemic effects of Lippia origanoides Kunth in diabetic rats
1000 Autor/in
  1. Miranda, Vinicius Carvalho |
  2. Pereira, Yago |
  3. Santos da Paz, Allane Patricia |
  4. Rodrigues de Souza, Keyla |
  5. Cristina Freitas da Silva, Márcia |
  6. Muto, Nilton |
  7. Romano Monteiro, Patrick |
  8. Santos, Agenor |
  9. Hamoy, Moises |
  10. MEDEIROS CARVALHO, MARIA DAS GRACAS FREIRE DE |
  11. Souza do Carmo, Iolanda |
  12. Silva, Maria Eduarda Moraes |
  13. de Sousa Lima Neto, José |
  14. Joia de Mello, Vanessa |
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-05-13
1000 Erschienen in
1000 Quellenangabe
  • 12(7):5131-5146
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/fsn3.4162 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Diabetes mellitus is a metabolic disorder commonly associated with atherosclerosis. Plants with therapeutic potential, such as Lippia origanoides Kunth, emerge as effective alternatives for treating these diseases. Therefore, this work aims to analyze the antihyperglycemic and antidyslipidemic potential of the hydroalcoholic extract of Lippia origanoides Kunth (ELo) in alloxan-diabetic rats. Animals were treated orally: normal control, hyperglycemic control, positive control glibenclamide (5 mg/kg), and groups treated with ELo (75, 150, and 250 mg/kg). Preclinical evaluation of ELo showed hypoglycemic, hypolipidemic, hepatic, and renal protective effects. At all doses, ELo significantly reduced hyperglycemia, triglycerides, total cholesterol, low-density lipoprotein, atherogenic index, atherogenic coefficient, and cardiovascular risk index (p < .05). Elo at different doses promoted an increase in insulin release compared to untreated animals (p < .05) and showed α-glucosidase inhibitory activity (p < .05). Also, ELo (250 mg/kg group) showed maximum reduction of hyperglycemia, alanine transaminase, aspartate aminotransferase, malonaldehyde, and urea compared to the hyperglycemic and glibenclamide groups, and creatinine only compared to the hyperglycemic groups (p < .05). The promising action of ELo in the context of diabetes may be related to the synergistic action of flavonoid compounds identified in liquid chromatography, whose pharmacological capabilities have already been documented in previous studies. The mechanisms may be the stimulation of insulin release; the inhibitory activity of α-glucosidase; improving general clinical conditions; and the antioxidant effects of the extract. These findings pave the way for the future development of an herbal presentation of L. origanoides Kunth as a hypoglycemic and cardiovascular protector with a lipid-lowering effect.
1000 Sacherschließung
lokal hypoglycemic
lokal cardiovascular protector
lokal Lippia origanoides Kunth
lokal diabetes
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWlyYW5kYSwgVmluaWNpdXMgQ2FydmFsaG8=|https://orcid.org/0000-0001-5291-3790|https://orcid.org/0000-0001-6084-6989|https://orcid.org/0000-0003-1093-3587|https://orcid.org/0000-0002-1315-2084|https://orcid.org/0000-0001-6125-5558|https://orcid.org/0000-0002-4946-2797|https://orcid.org/0000-0002-2690-2841|https://orcid.org/0000-0002-2931-4324|https://orcid.org/0000-0002-6161-7085|https://orcid.org/0000-0003-1456-2584|https://frl.publisso.de/adhoc/uri/U2lsdmEsIE1hcmlhIEVkdWFyZGEgTW9yYWVz|https://orcid.org/0000-0002-3933-6391|https://orcid.org/0000-0003-0359-9760
1000 Label
1000 Förderer
  1. Pró-Reitoria de Pesquisa e Pós-graduação da Universidade Federal do Pará |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Hypoglycemic and hypolipidemic effects of Lippia origanoides Kunth in diabetic rats
    Hypoglycemic and hypolipidemic effects of Lippia origanoides Kunth in diabetic rats
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Pró-Reitoria de Pesquisa e Pós-graduação da Universidade Federal do Pará |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6488988.rdf
1000 Erstellt am 2024-11-07T12:10:24.876+0100
1000 Erstellt von 286
1000 beschreibt frl:6488988
1000 Bearbeitet von 286
1000 Zuletzt bearbeitet 2024-11-07T12:12:04.176+0100
1000 Objekt bearb. Thu Nov 07 12:11:38 CET 2024
1000 Vgl. frl:6488988
1000 Oai Id
  1. oai:frl.publisso.de:frl:6488988 |
1000 Sichtbarkeit Metadaten public
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