Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana

  1. Luzarowska, Urszula ORCID logo
  2. Ruß, Anne-Kathrin ORCID logo
  3. Joubès, Jérôme ORCID logo
  4. Batsale, Marguerite ORCID logo
  5. Szymanski, Jedrzej ORCID logo
  6. P Thirumalaikumar, Venkatesh ORCID logo
  7. Luzarowski, Marcin ORCID logo
  8. Wu, Si ORCID logo
  9. Zhu, Feng ORCID logo
  10. Endres, Niklas ORCID logo
  11. Khedhayir, Sarah ORCID logo
  12. Schumacher, Julia ORCID logo
  13. Jasinska, Weronika ORCID logo
  14. Xu, Ke ORCID logo
  15. Correa Córdoba, Sandra Marcela ORCID logo
  16. Weil, Simy ORCID logo
  17. Skirycz, Aleksandra ORCID logo
  18. Fernie, Alisdair ORCID logo
  19. Li-Beisson, Yonghua ORCID logo
  20. Fusari, Corina M. ORCID logo
  21. Brotman, Yariv ORCID logo

Download
Luzarowska-Plant Cell-2023.pdf 12,59MB
WeightNameValue
1000 Titel
  • Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana
1000 Autor/in
  1. Luzarowska, Urszula |
  2. Ruß, Anne-Kathrin |
  3. Joubès, Jérôme |
  4. Batsale, Marguerite |
  5. Szymanski, Jedrzej |
  6. P Thirumalaikumar, Venkatesh |
  7. Luzarowski, Marcin |
  8. Wu, Si |
  9. Zhu, Feng |
  10. Endres, Niklas |
  11. Khedhayir, Sarah |
  12. Schumacher, Julia |
  13. Jasinska, Weronika |
  14. Xu, Ke |
  15. Correa Córdoba, Sandra Marcela |
  16. Weil, Simy |
  17. Skirycz, Aleksandra |
  18. Fernie, Alisdair |
  19. Li-Beisson, Yonghua |
  20. Fusari, Corina M. |
  21. Brotman, Yariv |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-03-03
1000 Erschienen in
1000 Quellenangabe
  • 35(6):1984-2005
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1093/plcell/koad059 |
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10226560/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Plant lipids are important as alternative sources of carbon and energy when sugars or starch are limited. Here, we applied combined heat and darkness or extended darkness to a panel of approximately 300 Arabidopsis (Arabidopsis thaliana) accessions to study lipid remodeling under carbon starvation. Natural allelic variation at 3-KETOACYL-COENZYME A SYNTHASE4 (KCS4), a gene encoding an enzyme involved in very long chain fatty-acid (VLCFA) synthesis, underlies the differential accumulation of polyunsaturated triacylglycerols (puTAGs) under stress. Ectopic expression of KCS4 in yeast and plants proved that KCS4 is a functional enzyme localized in the endoplasmic reticulum with specificity for C22 and C24 saturated acyl-CoA. Allelic mutants and transient overexpression in planta revealed the differential role of KCS4 alleles in VLCFA synthesis and leaf wax coverage, puTAG accumulation and biomass. Moreover, the region harboring KCS4 is under high selective pressure and allelic variation at KCS4 correlated with environmental parameters from the locales of Arabidopsis accessions. Our results provide evidence that KCS4 plays a decisive role in the subsequent fate of fatty acids released from chloroplast membrane lipids under carbon starvation. This work sheds light on both plant response mechanisms and the evolutionary events shaping the lipidome under carbon starvation.
1000 Sacherschließung
lokal GWAS
lokal natural variation
lokal Arabidopsis
lokal triacylglycerols
lokal fatty acids
lokal KCS4
lokal carbon starvation
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-3350-5297|https://orcid.org/0000-0002-4593-8698|https://orcid.org/0000-0001-5385-450X|https://orcid.org/0000-0002-4027-4992|https://orcid.org/0000-0003-1086-0920|https://orcid.org/0000-0002-5009-1460|https://orcid.org/0000-0002-2115-0468|https://orcid.org/0000-0001-8050-7167|https://orcid.org/0000-0002-9133-0843|https://orcid.org/0000-0001-5093-1020|https://orcid.org/0000-0003-3589-895X|https://orcid.org/0000-0001-6509-7315|https://orcid.org/0000-0003-3989-8041|https://orcid.org/0000-0002-1733-6737|https://orcid.org/0000-0002-5049-9271|https://orcid.org/0000-0002-5309-718X|https://orcid.org/0000-0002-7627-7925|https://orcid.org/0000-0001-9000-335X|https://orcid.org/0000-0003-1064-1816|https://orcid.org/0000-0001-6809-0266|https://orcid.org/0000-0001-6573-7845
1000 Label
1000 Förderer
  1. Israel Science Foundation |
1000 Fördernummer
  1. 859/19
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Israel Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 859/19
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6489196.rdf
1000 Erstellt am 2024-11-27T15:36:59.893+0100
1000 Erstellt von 325
1000 beschreibt frl:6489196
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2025-02-24T13:21:27.806+0100
1000 Objekt bearb. Mon Feb 24 13:21:11 CET 2025
1000 Vgl. frl:6489196
1000 Oai Id
  1. oai:frl.publisso.de:frl:6489196 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source