A non-canonical function of Arabidopsis ERECTA proteins and a role of the SWI3B subunit of the SWI/SNF chromatin remodeling complex in gibberellin signaling

  1. Sarnowska, Elzbieta
  2. Kubala, Szymon
  3. Cwiek, Pawel
  4. Sacharowski, Sebastian ORCID logo
  5. Oksinska, Paulina
  6. Steciuk, Jaroslaw
  7. Zaborowska, Magdalena
  8. Szurmak, Jakub M
  9. Dubianski, Roman
  10. Maassen, Anna
  11. Stachowiak, Malgorzata
  12. Huettel, Bruno
  13. Ciesla, Monika
  14. Nowicka, Klaudia
  15. Rolicka, Anna T
  16. Alseekh, Saleh ORCID logo
  17. Bucior, Ernest
  18. Franzen, Rainer
  19. Skoneczna, Anna
  20. Domagalska, Malgorzata A
  21. Amar, Samija
  22. Hajirezaei, Mohammad-Reza ORCID logo
  23. Siedlecki, Janusz A
  24. Fernie, Alisdair ORCID logo
  25. Davis, Seth J
  26. Sarnowski, Tomasz ORCID logo

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1000 Titel
  • A non-canonical function of Arabidopsis ERECTA proteins and a role of the SWI3B subunit of the SWI/SNF chromatin remodeling complex in gibberellin signaling
1000 Autor/in
  1. Sarnowska, Elzbieta |
  2. Kubala, Szymon |
  3. Cwiek, Pawel |
  4. Sacharowski, Sebastian |
  5. Oksinska, Paulina |
  6. Steciuk, Jaroslaw |
  7. Zaborowska, Magdalena |
  8. Szurmak, Jakub M |
  9. Dubianski, Roman |
  10. Maassen, Anna |
  11. Stachowiak, Malgorzata |
  12. Huettel, Bruno |
  13. Ciesla, Monika |
  14. Nowicka, Klaudia |
  15. Rolicka, Anna T |
  16. Alseekh, Saleh |
  17. Bucior, Ernest |
  18. Franzen, Rainer |
  19. Skoneczna, Anna |
  20. Domagalska, Malgorzata A |
  21. Amar, Samija |
  22. Hajirezaei, Mohammad-Reza |
  23. Siedlecki, Janusz A |
  24. Fernie, Alisdair |
  25. Davis, Seth J |
  26. Sarnowski, Tomasz |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-04-28
1000 Erschienen in
1000 Quellenangabe
  • 115(3):788-802
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1111/tpj.16261 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs) comprising ERECTA (ER), ERECTA-LIKE 1 (ERL1), and ERECTA-LIKE 2 (ERL2) controls epidermal patterning, inflorescence architecture, stomata development and patterning. These proteins are reported to be plasma-membrane associated. Here we show that the er/erl1/erl2 mutant exhibits impaired gibberellin (GA) biosynthesis and perception alongside broad transcriptional changes. The ERf kinase domains were found to localize to the nucleus where they interact with the SWI3B subunit of the SWI/SNF chromatin remodeling complex (CRCs). The er/erl1/erl2 mutant exhibits reduced SWI3B protein level and affected nucleosomal chromatin structure. Similarly to swi3c and brm plants with inactivated subunits of SWI/SNF CRCs, it also does not accumulate DELLA RGA and GAI proteins. The ER kinase phosphorylates SWI3B in vitro, and the inactivation of all ERf proteins leads to the decreased phosphorylation of SWI3B protein in vivo. The identified correlation between DELLA overaccumulation and SWI3B proteasomal degradation, and the physical interaction of SWI3B with DELLA proteins indicate an important role of SWI3B-containing SWI/SNF CRCs in gibberellin signaling. Co-localization of ER and SWI3B on GID1 (GIBBERELLIN INSENSITIVE DWARF 1) DELLA target gene promoter regions and abolished SWI3B binding to GID1 promoters in er/erl1/erl2 plants supports the conclusion that ERf-SWI/SNF CRC interaction is important for transcriptional control of GA receptors. Thus, the involvement of ERf proteins in transcriptional control of gene expression, and observed similar features for human HER2 (Epidermal Growth Family Receptor-member), indicate an exciting target for further studies of evolutionarily conserved non-canonical functions of eukaryotic membrane receptors.
1000 Sacherschließung
lokal DELLA
lokal HER2
lokal SWI3B
lokal ERECTA
lokal chromatin
lokal Arabidopsis
lokal SWI/SNF
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2Fybm93c2thLCBFbHpiaWV0YQ==|https://frl.publisso.de/adhoc/uri/S3ViYWxhLCBTenltb24g|https://frl.publisso.de/adhoc/uri/Q3dpZWssIFBhd2VsIA==|https://orcid.org/0000-0001-8220-9649|https://frl.publisso.de/adhoc/uri/T2tzaW5za2EsIFBhdWxpbmE=|https://frl.publisso.de/adhoc/uri/U3RlY2l1aywgSmFyb3NsYXc=|https://frl.publisso.de/adhoc/uri/WmFib3Jvd3NrYSwgTWFnZGFsZW5h|https://frl.publisso.de/adhoc/uri/U3p1cm1haywgSmFrdWIgTQ==|https://frl.publisso.de/adhoc/uri/RHViaWFuc2tpLCBSb21hbiA=|https://frl.publisso.de/adhoc/uri/TWFhc3NlbiwgQW5uYQ==|https://frl.publisso.de/adhoc/uri/U3RhY2hvd2lhaywgTWFsZ29yemF0YQ==|https://frl.publisso.de/adhoc/uri/SHVldHRlbCwgQnJ1bm8g|https://frl.publisso.de/adhoc/uri/Q2llc2xhLCBNb25pa2Eg|https://frl.publisso.de/adhoc/uri/Tm93aWNrYSwgS2xhdWRpYQ==|https://frl.publisso.de/adhoc/uri/Um9saWNrYSwgQW5uYSBU|https://orcid.org/0000-0003-2067-5235|https://frl.publisso.de/adhoc/uri/QnVjaW9yLCBFcm5lc3QgIA==|https://frl.publisso.de/adhoc/uri/RnJhbnplbiwgUmFpbmVyIA==|https://frl.publisso.de/adhoc/uri/U2tvbmVjem5hLCBBbm5hIA==|https://frl.publisso.de/adhoc/uri/RG9tYWdhbHNrYSwgTWFsZ29yemF0YSBB|https://frl.publisso.de/adhoc/uri/QW1hciwgU2FtaWph|https://orcid.org/0000-0002-9537-0121|https://frl.publisso.de/adhoc/uri/U2llZGxlY2tpLCBKYW51c3ogQQ==|https://orcid.org/0000-0001-9000-335X|https://frl.publisso.de/adhoc/uri/RGF2aXMsIFNldGggSg==|https://orcid.org/0000-0002-3805-2039
1000 Label
1000 Förderer
  1. Narodowym Centrum Nauki |
  2. Fundacja na rzecz Nauki Polskiej |
  3. Deutsche Forschungsgemeinschaft |
  4. Ministerstwo Edukacji i Nauki |
  5. Horizon 2020 Framework Programme |
  6. European Regional Development Fund |
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    1000 Förderer Fundacja na rzecz Nauki Polskiej |
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    1000 Förderer Deutsche Forschungsgemeinschaft |
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    1000 Förderer Ministerstwo Edukacji i Nauki |
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    1000 Förderer European Regional Development Fund |
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1000 Erstellt am 2024-11-27T16:28:24.209+0100
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