Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson's disease: Cross-sectional and longitudinal evidence from the LANDSCAPE study

  1. Ophey, Anja ORCID logo
  2. Wirtz, Kathrin
  3. Wolfsgruber, Steffen
  4. Balzer-Geldsetzer, Monika
  5. Berg, Daniela ORCID logo
  6. Hilker-Roggendorf, Rüdiger
  7. Kassubek, Jan ORCID logo
  8. Liepelt-Scarfone, Inga ORCID logo
  9. Becker, Sara ORCID logo
  10. Mollenhauer, Brit
  11. Reetz, Kathrin ORCID logo
  12. Riedel, Oliver ORCID logo
  13. Schulz, Jörg B. ORCID logo
  14. Storch, Alexander ORCID logo
  15. Trenkwalder, Claudia
  16. Witt, Karsten
  17. Wittchen, Hans-Ulrich
  18. Dodel, Richard ORCID logo
  19. Roeske, Sandra ORCID logo
  20. Kalbe, Elke ORCID logo

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Ophey-et-al_2024_Mid- and late-life lifestyle activities.pdf 1,39MB
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1000 Titel
  • Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson's disease: Cross-sectional and longitudinal evidence from the LANDSCAPE study
1000 Autor/in
  1. Ophey, Anja |
  2. Wirtz, Kathrin |
  3. Wolfsgruber, Steffen |
  4. Balzer-Geldsetzer, Monika |
  5. Berg, Daniela |
  6. Hilker-Roggendorf, Rüdiger |
  7. Kassubek, Jan |
  8. Liepelt-Scarfone, Inga |
  9. Becker, Sara |
  10. Mollenhauer, Brit |
  11. Reetz, Kathrin |
  12. Riedel, Oliver |
  13. Schulz, Jörg B. |
  14. Storch, Alexander |
  15. Trenkwalder, Claudia |
  16. Witt, Karsten |
  17. Wittchen, Hans-Ulrich |
  18. Dodel, Richard |
  19. Roeske, Sandra |
  20. Kalbe, Elke |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-07-01
1000 Erschienen in
1000 Quellenangabe
  • 271(8):5411-5424
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-024-12484-0 |
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11319368/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s00415-024-12484-0#Sec20 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Cognitive reserve (CR) is considered a protective factor for cognitive function and may explain interindividual differences of cognitive performance given similar levels of neurodegeneration, e.g., in Alzheimer´s disease. Recent evidence suggests that CR is also relevant in Parkinson’s disease (PD). OBJECTIVE: We aimed to explore the role of life-stage specific CR for overall cognition and specific cognitive domains cross-sectionally and longitudinally in PD. METHODS: The cross-sectional analysis with data from the DEMPARK/LANDSCAPE study included 81 individuals without cognitive impairment (PD-N) and 87 individuals with mild cognitive impairment (PD-MCI). Longitudinal data covered 4 years with over 500 observations. CR was operationalized with the Lifetime of Experiences Questionnaire (LEQ), capturing the complexity of lifestyle activities across distinct life-stages. Cognition was assessed using a comprehensive neuropsychological test battery. RESULTS: Higher LEQ scores, particularly from mid- and late-life, were observed in PD-N compared to PD-MCI [F(1,153) = 4.609, p = .033, ηp2 = 0.029]. They were significantly associated with better cognitive performance (0.200 ≤ β ≤ 0.292). Longitudinally, linear mixed effect models (0.236 ≤ marginal R2 ≤ 0.441) revealed that LEQ scores were positively related to cognitive performance independent of time. However, the decline in overall cognition and memory over time was slightly more pronounced with higher LEQ scores. CONCLUSIONS: This study emphasizes the association between complex lifestyle activities and cognition in PD. Data indicate that while CR might be related to a delay of cognitive decline, individuals with high CR may experience a more pronounced drop in overall cognition and memory. Future studies will have to replicate these findings, particularly regarding domain-specific effects and considering reverse causal mechanisms.
1000 Sacherschließung
lokal Cognitive reserve
lokal Cognitive dysfunction
lokal Lifestyle
lokal Parkinson's disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5858-7762|https://frl.publisso.de/adhoc/uri/V2lydHosIEthdGhyaW4=|https://frl.publisso.de/adhoc/uri/V29sZnNncnViZXIsIFN0ZWZmZW4=|https://frl.publisso.de/adhoc/uri/QmFsemVyLUdlbGRzZXR6ZXIsIE1vbmlrYQ==|https://orcid.org/0000-0001-5796-5442|https://frl.publisso.de/adhoc/uri/SGlsa2VyLVJvZ2dlbmRvcmYsIFLDvGRpZ2Vy|https://orcid.org/0000-0002-7106-9270|https://orcid.org/0000-0002-0875-892X|https://orcid.org/0000-0002-4595-580X|https://frl.publisso.de/adhoc/uri/TW9sbGVuaGF1ZXIsIEJyaXQ=|https://orcid.org/0000-0002-9730-9228|https://orcid.org/0000-0002-1721-502X|https://orcid.org/0000-0002-8903-0593|https://orcid.org/0000-0002-1133-9216|https://frl.publisso.de/adhoc/uri/VHJlbmt3YWxkZXIsIENsYXVkaWE=|https://frl.publisso.de/adhoc/uri/V2l0dCwgS2Fyc3Rlbg==|https://frl.publisso.de/adhoc/uri/V2l0dGNoZW4sIEhhbnMtVWxyaWNo|https://orcid.org/0000-0003-2044-6299|https://orcid.org/0000-0002-8262-4356|https://orcid.org/0000-0001-8603-2545
1000 Label
1000 Förderer
  1. Projekt DEAL |
  2. https://doi.org/10.13039/100004336 |
  3. https://doi.org/10.13039/100015998 |
  4. https://doi.org/10.13039/501100002347 |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. 01GI1008C
1000 Förderprogramm
  1. Open Access funding
  2. -
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer https://doi.org/10.13039/100004336 |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer https://doi.org/10.13039/100015998 |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer https://doi.org/10.13039/501100002347 |
    1000 Förderprogramm -
    1000 Fördernummer 01GI1008C
1000 Objektart article
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1000 Erstellt am 2025-01-21T09:21:59.098+0100
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