Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

  1. Kop, Benjamin R
  2. Shamli Oghli, Yazan
  3. Grippe, Talyta C
  4. Nandi, Tulika
  5. Lefkes, Judith
  6. Meijer, Sjoerd W
  7. Farboud, Soha
  8. Engels, Marwan
  9. Hamani, Michelle
  10. Null, Melissa
  11. Radetz, Angela
  12. Hassan, Umair
  13. Darmani, Ghazaleh
  14. Chetverikov, Andrey
  15. den Ouden, Hanneke EM
  16. Bergmann, Til Ole
  17. Chen, Robert
  18. Verhagen, Lennart
  19. Obleser, Jonas
  20. Roiser, Jonathan

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WeightNameValue
1000 Titel
  • Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans
1000 Autor/in
  1. Kop, Benjamin R |
  2. Shamli Oghli, Yazan |
  3. Grippe, Talyta C |
  4. Nandi, Tulika |
  5. Lefkes, Judith |
  6. Meijer, Sjoerd W |
  7. Farboud, Soha |
  8. Engels, Marwan |
  9. Hamani, Michelle |
  10. Null, Melissa |
  11. Radetz, Angela |
  12. Hassan, Umair |
  13. Darmani, Ghazaleh |
  14. Chetverikov, Andrey |
  15. den Ouden, Hanneke EM |
  16. Bergmann, Til Ole |
  17. Chen, Robert |
  18. Verhagen, Lennart |
  19. Obleser, Jonas |
  20. Roiser, Jonathan |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-08-27
1000 Erschienen in
1000 Quellenangabe
  • 12:RP88762
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.7554/eLife.88762 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349300/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS is already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one promising protocol, pulsed at 1000 Hz, has consistently resulted in motor cortical inhibition in humans (Fomenko et al., 2020). At the same time, a parallel research line has highlighted the potentially confounding influence of peripheral auditory stimulation arising from TUS pulsing at audible frequencies. In this study, we disentangle direct neuromodulatory and indirect auditory contributions to motor inhibitory effects of TUS. To this end, we include tightly matched control conditions across four experiments, one preregistered, conducted independently at three institutions. We employed a combined transcranial ultrasonic and magnetic stimulation paradigm, where TMS-elicited motor-evoked potentials (MEPs) served as an index of corticospinal excitability. First, we replicated motor inhibitory effects of TUS but showed through both tight controls and manipulation of stimulation intensity, duration, and auditory masking conditions that this inhibition was driven by peripheral auditory stimulation, not direct neuromodulation. Furthermore, we consider neuromodulation beyond driving overall excitation/inhibition and show preliminary evidence of how TUS might interact with ongoing neural dynamics instead. Primarily, this study highlights the substantial shortcomings in accounting for the auditory confound in prior TUS-TMS work where only a flip-over sham and no active control was used. The field must critically reevaluate previous findings given the demonstrated impact of peripheral confounds. Furthermore, rigorous experimental design via (in)active control conditions is required to make substantiated claims in future TUS studies. Only when direct effects are disentangled from those driven by peripheral confounds can TUS fully realize its potential for research and clinical applications.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
  2. Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
  3. Holland High Tech |
  4. Canadian Institutes of Health Research |
  5. Canadian Institutes of Health Research |
  6. Natural Sciences and Engineering Research Council of Canada |
  7. Natural Sciences and Engineering Research Council of Canada |
  8. Boehringer Ingelheim Stiftung |
1000 Fördernummer
  1. 18919
  2. 452-17-016
  3. HiTMaT-38H3
  4. FDN 154292
  5. ENG 173742
  6. RGPIN-2020-04176
  7. RTI-2020-0024
  8. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
    1000 Förderprogramm -
    1000 Fördernummer 18919
  2. 1000 joinedFunding-child
    1000 Förderer Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
    1000 Förderprogramm -
    1000 Fördernummer 452-17-016
  3. 1000 joinedFunding-child
    1000 Förderer Holland High Tech |
    1000 Förderprogramm -
    1000 Fördernummer HiTMaT-38H3
  4. 1000 joinedFunding-child
    1000 Förderer Canadian Institutes of Health Research |
    1000 Förderprogramm -
    1000 Fördernummer FDN 154292
  5. 1000 joinedFunding-child
    1000 Förderer Canadian Institutes of Health Research |
    1000 Förderprogramm -
    1000 Fördernummer ENG 173742
  6. 1000 joinedFunding-child
    1000 Förderer Natural Sciences and Engineering Research Council of Canada |
    1000 Förderprogramm -
    1000 Fördernummer RGPIN-2020-04176
  7. 1000 joinedFunding-child
    1000 Förderer Natural Sciences and Engineering Research Council of Canada |
    1000 Förderprogramm -
    1000 Fördernummer RTI-2020-0024
  8. 1000 joinedFunding-child
    1000 Förderer Boehringer Ingelheim Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6489597.rdf
1000 Erstellt am 2025-01-29T08:16:00.563+0100
1000 Erstellt von 336
1000 beschreibt frl:6489597
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2025-09-12T14:47:07.401+0200
1000 Objekt bearb. Mon Apr 14 10:31:24 CEST 2025
1000 Vgl. frl:6489597
1000 Oai Id
  1. oai:frl.publisso.de:frl:6489597 |
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