Frontostriatal salience network expansion in individuals in depression

  1. Lynch, Charles J.
  2. Elbau, Immanuel G.
  3. Ng, Tommy
  4. Ayaz, Aliza
  5. Zhu, Shasha
  6. Wolk, Danielle
  7. Manfredi, Nicola
  8. Johnson, Megan
  9. Chang, Megan
  10. Chou, Jolin
  11. Summerville, Indira
  12. Ho, Claire
  13. Lueckel, Maximilian
  14. Bukhari, Hussain
  15. Buchanan, Derrick
  16. Victoria, Lindsay W.
  17. Solomonov, Nili
  18. Goldwaser, Eric
  19. Moia, Stefano
  20. Caballero-Gaudes, Cesar
  21. Downar, Jonathan
  22. Vila-Rodriguez, Fidel
  23. Daskalakis, Zafiris J.
  24. Blumberger, Daniel M.
  25. Kay, Kendrick
  26. Aloysi, Amy
  27. Gordon, Evan M.
  28. Bhati, Mahendra T.
  29. Williams, Nolan
  30. Power, Jonathan D.
  31. Zebley, Benjamin
  32. Grosenick, Logan
  33. Gunning, Faith M.
  34. Liston, Conor

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1000 Titel
  • Frontostriatal salience network expansion in individuals in depression
1000 Autor/in
  1. Lynch, Charles J. |
  2. Elbau, Immanuel G. |
  3. Ng, Tommy |
  4. Ayaz, Aliza |
  5. Zhu, Shasha |
  6. Wolk, Danielle |
  7. Manfredi, Nicola |
  8. Johnson, Megan |
  9. Chang, Megan |
  10. Chou, Jolin |
  11. Summerville, Indira |
  12. Ho, Claire |
  13. Lueckel, Maximilian |
  14. Bukhari, Hussain |
  15. Buchanan, Derrick |
  16. Victoria, Lindsay W. |
  17. Solomonov, Nili |
  18. Goldwaser, Eric |
  19. Moia, Stefano |
  20. Caballero-Gaudes, Cesar |
  21. Downar, Jonathan |
  22. Vila-Rodriguez, Fidel |
  23. Daskalakis, Zafiris J. |
  24. Blumberger, Daniel M. |
  25. Kay, Kendrick |
  26. Aloysi, Amy |
  27. Gordon, Evan M. |
  28. Bhati, Mahendra T. |
  29. Williams, Nolan |
  30. Power, Jonathan D. |
  31. Zebley, Benjamin |
  32. Grosenick, Logan |
  33. Gunning, Faith M. |
  34. Liston, Conor |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-09-04
1000 Erschienen in
1000 Quellenangabe
  • 633(8030):624-633
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41586-024-07805-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11410656/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset1. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meaningful differences in brain network topography and connectivity between and in healthy individuals2,3,4, but this approach has not been applied in depression. Here, using precision functional mapping and several samples of deeply sampled individuals, we found that the frontostriatal salience network is expanded nearly twofold in the cortex of most individuals with depression. This effect was replicable in several samples and caused primarily by network border shifts, with three distinct modes of encroachment occurring in different individuals. Salience network expansion was stable over time, unaffected by mood state and detectable in children before the onset of depression later in adolescence. Longitudinal analyses of individuals scanned up to 62 times over 1.5 years identified connectivity changes in frontostriatal circuits that tracked fluctuations in specific symptoms and predicted future anhedonia symptoms. Together, these findings identify a trait-like brain network topology that may confer risk for depression and mood-state-dependent connectivity changes in frontostriatal circuits that predict the emergence and remission of depressive symptoms over time.
1000 Sacherschließung
lokal Diseases of the nervous system
lokal Emotion
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Frontostriatal salience network expansion in individuals in depression
    Frontostriatal salience network expansion in individuals in depression
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1000 Erstellt am 2025-01-29T08:17:26.866+0100
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1000 Zuletzt bearbeitet 2025-04-15T09:04:01.320+0200
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