Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age

  1. Schwartz, Christoph
  2. Ueberschaer, Moritz F.
  3. Rautalin, Ilari
  4. Grauvogel, Jürgen
  5. Bissolo, Marco
  6. Masalha, Waseem
  7. Steiert, Christine
  8. Schnell, Oliver
  9. Beck, Jürgen
  10. Ebel, Florian
  11. Bervini, David
  12. Raabe, Andreas
  13. Eibl, Thomas
  14. Steiner, Hans-Herbert
  15. Schebesch, Karl-Michael
  16. Shlobin, Nathan A.
  17. Nandoliya, Khizar R.
  18. Youngblood, Mark W.
  19. Chandler, James P.
  20. Magill, Stephen T.
  21. Romagna, Alexander
  22. Lehmberg, Jens
  23. Fuetsch, Manuel
  24. Spears, Julian
  25. Rezai, Arwin
  26. Ladisich, Barbara
  27. Demetz, Matthias
  28. Griessenauer, Christoph J.
  29. Niemelä, Mika
  30. Korja, Miikka

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1000 Titel
  • Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age
1000 Autor/in
  1. Schwartz, Christoph |
  2. Ueberschaer, Moritz F. |
  3. Rautalin, Ilari |
  4. Grauvogel, Jürgen |
  5. Bissolo, Marco |
  6. Masalha, Waseem |
  7. Steiert, Christine |
  8. Schnell, Oliver |
  9. Beck, Jürgen |
  10. Ebel, Florian |
  11. Bervini, David |
  12. Raabe, Andreas |
  13. Eibl, Thomas |
  14. Steiner, Hans-Herbert |
  15. Schebesch, Karl-Michael |
  16. Shlobin, Nathan A. |
  17. Nandoliya, Khizar R. |
  18. Youngblood, Mark W. |
  19. Chandler, James P. |
  20. Magill, Stephen T. |
  21. Romagna, Alexander |
  22. Lehmberg, Jens |
  23. Fuetsch, Manuel |
  24. Spears, Julian |
  25. Rezai, Arwin |
  26. Ladisich, Barbara |
  27. Demetz, Matthias |
  28. Griessenauer, Christoph J. |
  29. Niemelä, Mika |
  30. Korja, Miikka |
1000 Verlag Springer US
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-09-04
1000 Erschienen in
1000 Quellenangabe
  • 170(1):89-100
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11060-024-04780-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447097/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>To assess whether the Modified 5 (mFI-5) and 11 (mFI-11) Factor Frailty Indices associate with postoperative mortality, complications, and functional benefit in supratentorial meningioma patients aged over 80 years.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Baseline characteristics were collected from eight centers. Based on the patients’ preoperative status and comorbidities, frailty was assessed by the mFI-5 and mFI-11. The collected scores were categorized as “robust (mFI=0)”, “pre-frail (mFI=1)”, “frail (mFI=2)”, and “significantly frail (mFI≥3)”. Outcome was assessed by the Karnofsky Performance Scale (KPS); functional benefit was defined as improved KPS score. Additionally, we evaluated the patients’ functional independence (KPS≥70) after surgery.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The study population consisted of 262 patients (median age 83 years) with a median preoperative KPS of 70 (range 20 to 100). The 90-day and 1-year mortality were 9.0% and 13.2%; we recorded surgery-associated complications in 111 (42.4%) patients. At last follow-up within the postoperative first year, 101 (38.5%) patients showed an improved KPS, and 183 (69.8%) either gained or maintained functional independence. “Severely frail” patients were at an increased risk of death at 90 days (OR 16.3 (CI95% 1.7-158.7)) and one year (OR 11.7 (CI95% 1.9-71.7)); nine (42.9%) of severely frail patients died within the first year after surgery. The “severely frail” cohort had increased odds of suffering from surgery-associated complications (OR 3.9 (CI 95%) 1.3-11.3)), but also had a high chance for postoperative functional improvements by KPS≥20 (OR 6.6 (CI95% 1.2-36.2)).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The mFI-5 and mFI-11 associate with postoperative mortality, complications, and functional benefit. Even though “severely frail” patients had the highest risk morbidity and mortality, they had the highest chance for functional improvement.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Aged, 80 and over [MeSH]
lokal Supratentorial Neoplasms/surgery [MeSH]
lokal Postoperative Complications/mortality [MeSH]
lokal Frail Elderly [MeSH]
lokal Frailty/complications [MeSH]
lokal Postoperative Complications/epidemiology [MeSH]
lokal Meningeal Neoplasms/surgery [MeSH]
lokal Mortality
lokal Male [MeSH]
lokal Meningioma/surgery [MeSH]
lokal Modified 5 (mFI-5) and 11 (mFI-11) Factor Frailty Indices
lokal Meningioma
lokal Meningeal Neoplasms/mortality [MeSH]
lokal Karnofsky Performance Status [MeSH]
lokal Female [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Functional outcome
lokal Elderly
lokal Humans [MeSH]
lokal Meningioma/mortality [MeSH]
lokal Retrospective Studies [MeSH]
lokal Frailty/mortality [MeSH]
lokal Research
lokal Prognosis [MeSH]
lokal Supratentorial Neoplasms/mortality [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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