|
1000
|
Abstract/Summary
|
-
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. <jats:italic>Candida blankii</jats:italic> is one of these emerging pathogens and is known for its reduced susceptibility to multiple antifungals.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>To obtain more insight into the characteristics of this species, 26 isolates reported as <jats:italic>C. blankii</jats:italic> were investigated using genetic and phenotypical approaches.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Among the 26 isolates, seven recovered either from blood, sputum, urine, or the oral cavity, displayed substantial genetic and some phenotypical differences compared to the other isolates, which were confirmed as <jats:italic>C. blankii</jats:italic>. We consider these seven strains to represent a novel species, <jats:italic>Tardiomyces depauwii</jats:italic>. Phylogenomics assigned <jats:italic>C. blankii, C. digboiensis,</jats:italic> and the novel species in a distinct branch within the order <jats:italic>Dipodascales</jats:italic>, for which the novel genus <jats:italic>Tardiomyces</jats:italic> is erected. The new combinations <jats:italic>Tardiomyces blankii</jats:italic> and <jats:italic>Tardiomyces digboiensis</jats:italic> are introduced. Differences with related, strictly environmental genera <jats:italic>Sugiyamaella, Crinitomyces,</jats:italic> and <jats:italic>Diddensiella</jats:italic> are enumerated. All three <jats:italic>Tardiomyces</jats:italic> species share the rare ability to grow up to 42 °C, display slower growth in nutrient-poor media, and show a reduced susceptibility to azoles and echinocandins. Characteristics of <jats:italic>T. depauwii</jats:italic> include high MIC values with voriconazole and a unique protein pattern.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>We propose the novel yeast species <jats:italic>Tardiomyces depauwii</jats:italic> and the transfer of <jats:italic>C. blankii</jats:italic> and <jats:italic>C. digboiensis</jats:italic> to the novel <jats:italic>Tardiomyces</jats:italic> genus.</jats:p>
</jats:sec>
|
|
1000
|
Hinweis
|
-
DeepGreen-ID: 2a6f8133e59546c29a2998ee8d3644f2 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
|
