Rapid differentiation of MOGAD and MS after a single optic neuritis

  1. Pakeerathan, T.
  2. Havla, J.
  3. Schwake, C.
  4. Salmen, A.
  5. Ringelstein, M.
  6. Aktas, O.
  7. Weise, M.
  8. Gernert, J. A.
  9. Kornek, B.
  10. Bsteh, G.
  11. Pröbstel, A.-K.
  12. Papadopoulou, A.
  13. Kulsvehagen, L.
  14. Ayroza Galvão Ribeiro Gomes, A. B.
  15. Cerdá-Fuertes, N.
  16. Oertel, F. C.
  17. Duchow, A. S.
  18. Paul, F.
  19. Stellmann, J. P.
  20. Stolowy, N.
  21. Hellwig, K.
  22. Schneider-Gold, C.
  23. Kümpfel, T.
  24. Gold, R.
  25. Albrecht, P.
  26. Ayzenberg, I.

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WeightNameValue
1000 Titel
  • Rapid differentiation of MOGAD and MS after a single optic neuritis
1000 Autor/in
  1. Pakeerathan, T. |
  2. Havla, J. |
  3. Schwake, C. |
  4. Salmen, A. |
  5. Ringelstein, M. |
  6. Aktas, O. |
  7. Weise, M. |
  8. Gernert, J. A. |
  9. Kornek, B. |
  10. Bsteh, G. |
  11. Pröbstel, A.-K. |
  12. Papadopoulou, A. |
  13. Kulsvehagen, L. |
  14. Ayroza Galvão Ribeiro Gomes, A. B. |
  15. Cerdá-Fuertes, N. |
  16. Oertel, F. C. |
  17. Duchow, A. S. |
  18. Paul, F. |
  19. Stellmann, J. P. |
  20. Stolowy, N. |
  21. Hellwig, K. |
  22. Schneider-Gold, C. |
  23. Kümpfel, T. |
  24. Gold, R. |
  25. Albrecht, P. |
  26. Ayzenberg, I. |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-09-09
1000 Erschienen in
1000 Quellenangabe
  • 271(11):7222-7231
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-024-12666-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561115/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS) and myelin-oligodendrocyte-glycoprotein IgG-associated disease (MOGAD). This study evaluated the applicability of optical coherence tomography (OCT) for differentiating between both diseases in two independent cohorts.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>One hundred sixty two patients from seven sites underwent standard OCT and high-contrast visual acuity (HCVA) testing at least 6 months after first ON. Of these, 100 patients (32 MOGAD, 68 MS) comprised the primary investigational cohort, while 62 patients (31 MOGAD, 31 MS) formed a validation cohort. A composite score distinguishing between MOGAD and MS was developed using multivariate logistic regression.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Bilateral simultaneous ON occurred more frequently in MOGAD compared to MS (46.9 vs. 11.8%, <jats:italic>p</jats:italic> &lt; 0.001). OCT revealed more peripapillary retinal nerve fiber layer (pRNFL) atrophy in all segments in MOGAD compared to predominantly temporal pRNFL atrophy in MS (<jats:italic>p</jats:italic> &lt; 0.001). HCVA was better preserved in MS (<jats:italic>p</jats:italic> = 0.007). pRNFL thickness in all except for temporal segments was suitable for differentiating MOGAD and MS. Simultaneous bilateral ON and critical atrophy in nasal (&lt; 58.5 µm) and temporal superior (&lt; 105.5 µm) segments were included into the composite score as three independent predictors for MOGAD. The composite score distinguished MOGAD from MS with 75% sensitivity and 90% specificity in the investigational cohort, and 68% sensitivity and 87% specificity in the validation cohort.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Following a single ON-episode, MOGAD exhibits more pronounced global pRNFL atrophy and lower visual acuity after ON compared to MS. The introduced OCT-based composite score enabled differentiation between the two entities across both cohorts.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Demyelinating Autoimmune Diseases, CNS/diagnostic imaging [MeSH]
lokal Myelin-oligodendrocyte-glycoprotein IgG
lokal Multiple Sclerosis/diagnosis [MeSH]
lokal Visual evoked potential
lokal Tomography, Optical Coherence [MeSH]
lokal Diagnosis, Differential [MeSH]
lokal Optic neuritis
lokal Cohort Studies [MeSH]
lokal Optical coherence tomography
lokal Male [MeSH]
lokal Myelin oligodendrocyte glycoprotein IgG-associated disease
lokal Visual Acuity/physiology [MeSH]
lokal Myelin-Oligodendrocyte Glycoprotein/immunology [MeSH]
lokal Multiple Sclerosis/diagnostic imaging [MeSH]
lokal Female [MeSH]
lokal Optic Neuritis/diagnosis [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Middle Aged [MeSH]
lokal Multiple Sclerosis/complications [MeSH]
lokal Optic Neuritis/diagnostic imaging [MeSH]
lokal Demyelinating Autoimmune Diseases, CNS/diagnosis [MeSH]
lokal Multiple Sclerosis/pathology [MeSH]
lokal Multiple sclerosis
lokal Original Communication
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  • DeepGreen-ID: 9703d584581c422a8af31262b1886314 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search) ; at least one of the mandatory fields 'given-names' and 'family-name' is missing for the ORCID profile of 'Ayzenberg, I.' (https://orcid.org/0000-0002-6009-792X)
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  1. Katholisches Klinikum Bochum gGmbh |
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  1. Rapid differentiation of MOGAD and MS after a single optic neuritis
    Rapid differentiation of MOGAD and MS after a single optic neuritis
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    1000 Förderer Katholisches Klinikum Bochum gGmbh |
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