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1000
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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:p>The aim of this study was to analyze signal loss (SL) resulting from low signal quality of pulse oximetry-derived hemoglobin oxygen saturation (SpO<jats:sub>2</jats:sub>) measurements during prolonged hypoxemic episodes (pHE) in very preterm infants receiving automatic oxygen control (AOC). We did a post hoc analysis of a randomized crossover study of AOC, programmed to set FiO<jats:sub>2</jats:sub> to “back-up FiO<jats:sub>2</jats:sub>” during SL. In 24 preterm infants (median (interquartile range)) gestational age 25.3 (24.6 to 25.6) weeks, recording time 12.7 h (12.2 to 13.6 h) per infant, we identified 76 pHEs (median duration 119 s (86 to 180 s)). In 50 (66%) pHEs, SL occurred for a median duration of 51 s (33 to 85 s) and at a median frequency of 2 (1 to 2) SL-periods per pHE. SpO<jats:sub>2</jats:sub> before and after SL was similar (82% (76 to 88%) vs 82% (76 to 87%), <jats:italic>p</jats:italic> = 0.3)).</jats:p><jats:p><jats:italic> Conclusion</jats:italic>: SL is common during pHE and must hence be considered in AOC-algorithm designs. Administering a “backup FiO<jats:sub>2</jats:sub>” (which reflects FiO<jats:sub>2</jats:sub>-requirements during normoxemia) during SL may prolong pHE with SL.</jats:p><jats:p><jats:italic> Trial registration</jats:italic>: The study was registered at <jats:ext-link xmlns:xlink='http://www.w3.org/1999/xlink' ext-link-type='uri' xlink:href='http://www.clinicaltrials.gov'>www.clinicaltrials.gov</jats:ext-link> under the registration no. NCT03785899.
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<jats:td colspan='2'><jats:bold>What is Known:</jats:bold><jats:italic>• Previous studies examined SpO2 signal loss (SL) during routine manual oxygen control being rare, but pronounced in lower SpO2 states.</jats:italic><jats:italic>• Oxygen titration during SL is unlikely to be beneficial as SpO2 may recover to a normoxic range.</jats:italic></jats:td>
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<jats:td colspan='2'><jats:bold>What is New:</jats:bold><jats:italic>• Periods of low signal quality of SpO2 are common during pHEs and while supported with automated oxygen control (SPOC), FiO2 is set to a back-up value reflecting FiO2 requirements during normoxemia in response to SL, although SpO2 remained below target until signal recovery.</jats:italic><jats:italic>• FiO2 overshoots following pHEs were rare during AOC and occurred with a delayed onset; therefore, increased FiO2 during SL does not necessarily lead to overshoots.</jats:italic></jats:td>
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1000
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Hinweis
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DeepGreen-ID: 7b3918de033a4ca2af0c5e7a05676a76 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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