Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)

  1. Sharma, Monita ORCID logo
  2. Huber, Erin
  3. Arnesdotter, Emma
  4. Behrsing, Holger P.
  5. Bettmann, Adam
  6. Brandwein, David
  7. Constant, Samuel
  8. Date, Rahul
  9. Deshpande, Abhay
  10. Fabian, Eric
  11. Gupta, Amit
  12. Gutierrez, Robert
  13. Gutleb, Arno C.
  14. Hargrove, Marie M.
  15. Hollings, Michael
  16. Hutter, Victoria
  17. Jarabek, Annie M.
  18. Kaluzhny, Yulia
  19. Landsiedel, Robert
  20. Milchak, Lawrence
  21. Moyer, Robert A.
  22. Murray, Jessica R.
  23. Page, Kathryn
  24. Patel, Manish
  25. Pearson, Stephanie N.
  26. Petersen, Elijah J.
  27. Reinke, Emily
  28. Roldan, Nuria
  29. Roper, Clive
  30. Scaglione, Jamie B.
  31. Settivari, Raja S.
  32. Stucki, Andreas O.
  33. Verstraelen, Sandra
  34. Wallace, Joanne L.
  35. McCullough, Shaun
  36. Clippinger, Amy J.

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WeightNameValue
1000 Titel
  • Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)
1000 Autor/in
  1. Sharma, Monita |
  2. Huber, Erin |
  3. Arnesdotter, Emma |
  4. Behrsing, Holger P. |
  5. Bettmann, Adam |
  6. Brandwein, David |
  7. Constant, Samuel |
  8. Date, Rahul |
  9. Deshpande, Abhay |
  10. Fabian, Eric |
  11. Gupta, Amit |
  12. Gutierrez, Robert |
  13. Gutleb, Arno C. |
  14. Hargrove, Marie M. |
  15. Hollings, Michael |
  16. Hutter, Victoria |
  17. Jarabek, Annie M. |
  18. Kaluzhny, Yulia |
  19. Landsiedel, Robert |
  20. Milchak, Lawrence |
  21. Moyer, Robert A. |
  22. Murray, Jessica R. |
  23. Page, Kathryn |
  24. Patel, Manish |
  25. Pearson, Stephanie N. |
  26. Petersen, Elijah J. |
  27. Reinke, Emily |
  28. Roldan, Nuria |
  29. Roper, Clive |
  30. Scaglione, Jamie B. |
  31. Settivari, Raja S. |
  32. Stucki, Andreas O. |
  33. Verstraelen, Sandra |
  34. Wallace, Joanne L. |
  35. McCullough, Shaun |
  36. Clippinger, Amy J. |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-10-04
1000 Erschienen in
1000 Quellenangabe
  • 99(1):57-66
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-024-03879-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742365/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title> <jats:p>Standard information reporting helps to ensure that assay conditions and data are consistently reported and to facilitate inter-laboratory comparisons. Here, we present recommendations on minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA). The TEER assay is extensively used to evaluate the health of an epithelial/endothelial cell culture model and as an indicator of the potential toxicity of a test substance. This publication is the result of an international collaboration─called the RespTox (Respiratory Toxicity) Collaborative─through which twelve laboratories shared their protocols for assessing the barrier function of respiratory epithelial cells using the TEER assay following exposure to substances. The protocols from each laboratory were reviewed to identify general steps for performing the TEER assay, interlaboratory differences between steps, the rationale for differences, whether these differences impact results or cross-laboratory comparisons between TEER measurements. While the MIRTA recommendations are focused on respiratory epithelial cell systems, these recommendations can be adapted for other cell systems that form barriers. The use of these recommendations will support data transparency and reproducibility, reduce challenges in data interpretation, enable cross-laboratory comparisons, help assess study quality, and facilitate the incorporation of the TEER assay into national and international testing guidance.</jats:p>
1000 Sacherschließung
lokal Biological Assay/standards [MeSH]
lokal TEER
lokal Humans [MeSH]
lokal In vitro
lokal Review Article
lokal Endothelial Cells/drug effects [MeSH]
lokal Animals [MeSH]
lokal Barrier integrity
lokal Respiratory toxicity
lokal Epithelial Cells/drug effects [MeSH]
lokal Inhalation
lokal Reproducibility of Results [MeSH]
lokal Electric Impedance [MeSH]
lokal Biological Assay/methods [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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