GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)

  1. Katzdobler, Sabrina
  2. Nübling, Georg
  3. Klietz, Martin
  4. Fietzek, Urban M.
  5. Palleis, Carla
  6. Bernhardt, Alexander M.
  7. Wegner, Florian
  8. Huber, Meret
  9. Rogozinski, Sophia
  10. Schneider, Luisa-Sophie
  11. Spruth, Eike Jakob
  12. Beyle, Aline
  13. Vogt, Ina R.
  14. Brandt, Moritz
  15. Hansen, Niels
  16. Glanz, Wenzel
  17. Brockmann, Kathrin
  18. Spottke, Annika
  19. Hoffmann, Daniel C.
  20. Peters, Oliver
  21. Priller, Josef
  22. Wiltfang, Jens
  23. Düzel, Emrah
  24. Schneider, Anja
  25. Falkenburger, Björn
  26. Klockgether, Thomas
  27. Gasser, Thomas
  28. Nuscher, Brigitte
  29. Haass, Christian
  30. Höglinger, Günter
  31. Levin, Johannes ORCID logo

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1000 Titel
  • GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)
1000 Autor/in
  1. Katzdobler, Sabrina |
  2. Nübling, Georg |
  3. Klietz, Martin |
  4. Fietzek, Urban M. |
  5. Palleis, Carla |
  6. Bernhardt, Alexander M. |
  7. Wegner, Florian |
  8. Huber, Meret |
  9. Rogozinski, Sophia |
  10. Schneider, Luisa-Sophie |
  11. Spruth, Eike Jakob |
  12. Beyle, Aline |
  13. Vogt, Ina R. |
  14. Brandt, Moritz |
  15. Hansen, Niels |
  16. Glanz, Wenzel |
  17. Brockmann, Kathrin |
  18. Spottke, Annika |
  19. Hoffmann, Daniel C. |
  20. Peters, Oliver |
  21. Priller, Josef |
  22. Wiltfang, Jens |
  23. Düzel, Emrah |
  24. Schneider, Anja |
  25. Falkenburger, Björn |
  26. Klockgether, Thomas |
  27. Gasser, Thomas |
  28. Nuscher, Brigitte |
  29. Haass, Christian |
  30. Höglinger, Günter |
  31. Levin, Johannes |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-09-10
1000 Erschienen in
1000 Quellenangabe
  • 271(10):6991-6999
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-024-12647-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447157/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Multiple system atrophy (MSA), an atypical parkinsonian syndrome, is a rapidly progressive neurodegenerative disease with currently no established fluid biomarkers available. MSA is characterized by an oligodendroglial α-synucleinopathy, progressive neuronal cell loss and concomitant astrocytosis. Here, we investigate glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) as fluid biomarkers for differential diagnosis, assessment of clinical disease severity and prediction of disease progression in MSA.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>GFAP and NfL levels were analyzed in plasma and CSF samples of 47 MSA patients as well as 24 Parkinson’s disease (PD) and 25 healthy controls (HC) as reference cohorts. In MSA, biomarker levels were correlated to baseline and longitudinal clinical disease severity (UMSARS scores).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>In MSA, GFAP levels in CSF and plasma predicted baseline clinical disease severity as indicated by UMSARS scores, while NfL levels predicted clinical disease progression as indicated by longitudinal changes in UMSARS scores. Cross-sectionally, NfL levels in CSF and plasma were significantly elevated in MSA compared to both PD and HC. Receiver operating curves (ROC) indicated high diagnostic accuracy of NfL for distinguishing MSA from PD (CSF: AUC = 0.97, 95% CI 0.90–1.00; plasma: AUC = 0.90, 95% CI 0.81–1.00).</jats:p> </jats:sec><jats:sec> <jats:title>Discussion</jats:title> <jats:p>In MSA, GFAP shows promise as novel biomarker for assessing current clinical disease severity, while NfL might serve as biomarker for prediction of disease progression and differential diagnosis of MSA against PD.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Fluid biomarkers
lokal Parkinson Disease/blood [MeSH]
lokal Disease Progression [MeSH]
lokal Neurofilament Proteins/cerebrospinal fluid [MeSH]
lokal Aged [MeSH]
lokal Neurofilament light chain
lokal Neuroinflammation
lokal Multiple system atrophy
lokal Glial fibrillary acidic protein
lokal Diagnosis, Differential [MeSH]
lokal Male [MeSH]
lokal Neurofilament Proteins/blood [MeSH]
lokal Glial Fibrillary Acidic Protein/cerebrospinal fluid [MeSH]
lokal Multiple System Atrophy/blood [MeSH]
lokal Multiple System Atrophy/diagnosis [MeSH]
lokal Female [MeSH]
lokal Biomarkers/blood [MeSH]
lokal Humans [MeSH]
lokal Severity of Illness Index [MeSH]
lokal Glial Fibrillary Acidic Protein/blood [MeSH]
lokal Middle Aged [MeSH]
lokal Cross-Sectional Studies [MeSH]
lokal Parkinson Disease/diagnosis [MeSH]
lokal Biomarkers/cerebrospinal fluid [MeSH]
lokal ROC Curve [MeSH]
lokal Parkinson Disease/cerebrospinal fluid [MeSH]
lokal Multiple System Atrophy/cerebrospinal fluid [MeSH]
lokal Short Commentary
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Deutsche Forschungsgemeinschaft |
  2. Anton and Petra Ehrmann-Stiftung |
  3. Lüneburg Foundation |
  4. Klinikum der Universität München |
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