Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin–angiotensin–aldosterone system on COVID-19 disease

  1. Zobel, Christian Matthias ORCID logo
  2. Kuhn, Hartmut ORCID logo
  3. Schreiner, Maximilian ORCID logo
  4. Wenzel, Werner ORCID logo
  5. Wendtland, Jasper ORCID logo
  6. Goekeri, Cengiz ORCID logo
  7. Scheit, Lorenz ORCID logo
  8. Oltmanns, Klaas
  9. Rauschning, Dominic ORCID logo
  10. Grossegesse, Marica ORCID logo
  11. Hofmann, Natalie
  12. Wirtz, Hubert ORCID logo
  13. Spethmann, Sebastian ORCID logo
  14. BwKrhs-Covid-Research-Group
  15. Baumgarten, Ullrich
  16. Wageloehner, Tobias
  17. Neumann, Nino
  18. Mueller, Annette
  19. Mueller, Rico
  20. Krueger, Jan Philip
  21. Borchert, Alena
  22. Weinreich, Felix
  23. Keidel, Franziska
  24. Koch, Maria
  25. Schüßler, Meike

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1000 Titel
  • Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin–angiotensin–aldosterone system on COVID-19 disease
1000 Autor/in
  1. Zobel, Christian Matthias |
  2. Kuhn, Hartmut |
  3. Schreiner, Maximilian |
  4. Wenzel, Werner |
  5. Wendtland, Jasper |
  6. Goekeri, Cengiz |
  7. Scheit, Lorenz |
  8. Oltmanns, Klaas |
  9. Rauschning, Dominic |
  10. Grossegesse, Marica |
  11. Hofmann, Natalie |
  12. Wirtz, Hubert |
  13. Spethmann, Sebastian |
  14. BwKrhs-Covid-Research-Group |
  15. Baumgarten, Ullrich |
  16. Wageloehner, Tobias |
  17. Neumann, Nino |
  18. Mueller, Annette |
  19. Mueller, Rico |
  20. Krueger, Jan Philip |
  21. Borchert, Alena |
  22. Weinreich, Felix |
  23. Keidel, Franziska |
  24. Koch, Maria |
  25. Schüßler, Meike |
1000 Verlag BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-01-10
1000 Erschienen in
1000 Quellenangabe
  • 21(1):15
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12985-023-02283-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782794/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The coronavirus disease 2019 (COVID-19) pandemic is driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which has led to an enormous burden on patient morbidity and mortality. The renin–angiotensin–aldosterone system (RAAS) plays a significant role in various pulmonary diseases. Since SARS-CoV-2 utilizes the angiotensin-converting enzyme (ACE)2 receptor to exert its virulence and pathogenicity, the RAAS is of particular importance in COVID 19.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Our preliminary study investigates retrospectively the influence of selected ACE-polymorphisms (I/D location at intron 16 in the B-coding sequence (rs4646994) and A-240T (rs 4291) at the A-promoter) as well as ACE1 and ACE2 serum levels on disease severity and the inflammatory response in inpatients and outpatients with COVID-19.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Our study included 96 outpatients and 88 inpatients (65.9% male, mean age 60 years) with COVID-19 from April to December 2020 in four locations in Germany. Of the hospitalized patients, 88.6% participants were moderately ill (n = 78, 64% male, median age 60 years), and 11.4% participants were severely ill or deceased (n = 10, 90% male, median age 71 years). We found no polymorphism-related difference in disease, in age distribution, time to hospitalization and time of hospitalization for the inpatient group. ACE1 serum levels were significantly increased in the DD compared to the II polymorphism and in the TT compared to the AA polymorphism. There was no significant difference in ACE 1 serum levels l between moderately ill and severely ill patients. However, participants requiring oxygen supplementation had significantly elevated ACE1 levels compared to participants not requiring oxygen, with no difference in ACE2 levels whereas females had significantly higher ACE2 levels.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Although there were no differences in the distribution of ACE polymorphisms in disease severity, we found increased proinflammatory regulation of the RAAS in patients with oxygen demand and increased serum ACE2 levels in women, indicating a possible enhanced anti-inflammatory immune response.</jats:p> <jats:p><jats:italic>Clinical trial registration</jats:italic>: PreBiSeCov: German Clinical Trials Register, DRKS-ID: DRKS00021591, Registered on 27th April 2020.</jats:p> </jats:sec>
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Female [MeSH]
lokal SARS-CoV2
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Inflammation
lokal Oxygen [MeSH]
lokal SARS-CoV-2/genetics [MeSH]
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal COVID-19
lokal Mutagenesis, Insertional [MeSH]
lokal Renin-Angiotensin System/genetics [MeSH]
lokal Male [MeSH]
lokal ACE-polymorphism
lokal Peptidyl-Dipeptidase A/genetics [MeSH]
lokal Research
lokal COVID-19 [MeSH]
lokal Angiotensin-Converting Enzyme 2/genetics [MeSH]
lokal Renin–angiotensin–aldosteron-system (RAAS)
lokal Coronaviruses: emerging and re-emerging pathogens in humans and animals
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6358-1215|https://orcid.org/0000-0001-8142-3192|https://orcid.org/0000-0002-5719-2272|https://orcid.org/0000-0002-4003-6644|https://orcid.org/0000-0002-3015-8226|https://orcid.org/0000-0002-1616-4005|https://orcid.org/0000-0003-1459-5976|https://frl.publisso.de/adhoc/uri/T2x0bWFubnMsIEtsYWFz|https://orcid.org/0000-0001-9284-8778|https://orcid.org/0000-0002-9369-8203|https://frl.publisso.de/adhoc/uri/SG9mbWFubiwgTmF0YWxpZQ==|https://orcid.org/0000-0003-4848-1459|https://orcid.org/0000-0003-0987-8007|https://frl.publisso.de/adhoc/uri/QndLcmhzLUNvdmlkLVJlc2VhcmNoLUdyb3Vw|https://frl.publisso.de/adhoc/uri/QmF1bWdhcnRlbiwgVWxscmljaA==|https://frl.publisso.de/adhoc/uri/V2FnZWxvZWhuZXIsIFRvYmlhcw==|https://frl.publisso.de/adhoc/uri/TmV1bWFubiwgTmlubw==|https://frl.publisso.de/adhoc/uri/TXVlbGxlciwgQW5uZXR0ZQ==|https://frl.publisso.de/adhoc/uri/TXVlbGxlciwgUmljbw==|https://frl.publisso.de/adhoc/uri/S3J1ZWdlciwgSmFuIFBoaWxpcA==|https://frl.publisso.de/adhoc/uri/Qm9yY2hlcnQsIEFsZW5h|https://frl.publisso.de/adhoc/uri/V2VpbnJlaWNoLCBGZWxpeA==|https://frl.publisso.de/adhoc/uri/S2VpZGVsLCBGcmFuemlza2E=|https://frl.publisso.de/adhoc/uri/S29jaCwgTWFyaWE=|https://frl.publisso.de/adhoc/uri/U2Now7zDn2xlciwgTWVpa2U=
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  1. Sanitätsakademie der Bundeswehr, Abteilung E |
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