The neural signature of psychomotor disturbance in depression

  1. Wüthrich, Florian ORCID logo
  2. Lefebvre, Stephanie ORCID logo
  3. MITTAL, VIJAY ORCID logo
  4. Shankman, Stewart ORCID logo
  5. Alexander, Nina
  6. Brosch, Katharina ORCID logo
  7. Flinkenflügel, Kira
  8. Goltermann, Janik
  9. Grotegerd, Dominik ORCID logo
  10. Hahn, Tim ORCID logo
  11. Jamalabadi, Hamidreza
  12. Jansen, Andreas
  13. Leehr, Elisabeth J.
  14. Meinert, Susanne ORCID logo
  15. Nenadić, Igor ORCID logo
  16. Nitsch, Robert
  17. Stein, Frederike
  18. Straube, Benjamin ORCID logo
  19. Teutenberg, Lea
  20. Thiel, Katharina
  21. Thomas-Odenthal, Florian ORCID logo
  22. Usemann, Paula
  23. Winter, Alexandra ORCID logo
  24. Dannlowski, Udo
  25. Kircher, Tilo
  26. Walther, Sebastian ORCID logo

Download
41380_2023_Article_2327.pdf 2,04MB
WeightNameValue
1000 Titel
  • The neural signature of psychomotor disturbance in depression
1000 Autor/in
  1. Wüthrich, Florian |
  2. Lefebvre, Stephanie |
  3. MITTAL, VIJAY |
  4. Shankman, Stewart |
  5. Alexander, Nina |
  6. Brosch, Katharina |
  7. Flinkenflügel, Kira |
  8. Goltermann, Janik |
  9. Grotegerd, Dominik |
  10. Hahn, Tim |
  11. Jamalabadi, Hamidreza |
  12. Jansen, Andreas |
  13. Leehr, Elisabeth J. |
  14. Meinert, Susanne |
  15. Nenadić, Igor |
  16. Nitsch, Robert |
  17. Stein, Frederike |
  18. Straube, Benjamin |
  19. Teutenberg, Lea |
  20. Thiel, Katharina |
  21. Thomas-Odenthal, Florian |
  22. Usemann, Paula |
  23. Winter, Alexandra |
  24. Dannlowski, Udo |
  25. Kircher, Tilo |
  26. Walther, Sebastian |
1000 Verlag Nature Publishing Group UK
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-12-01
1000 Erschienen in
1000 Quellenangabe
  • 29(2):317-326
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41380-023-02327-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116107/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Up to 70% of patients with major depressive disorder present with psychomotor disturbance (PmD), but at the present time understanding of its pathophysiology is limited. In this study, we capitalized on a large sample of patients to examine the neural correlates of PmD in depression. This study included 820 healthy participants and 699 patients with remitted (<jats:italic>n</jats:italic> = 402) or current (<jats:italic>n</jats:italic> = 297) depression. Patients were further categorized as having psychomotor retardation, agitation, or no PmD. We compared resting-state functional connectivity (ROI-to-ROI) between nodes of the cerebral motor network between the groups, including primary motor cortex, supplementary motor area, sensory cortex, superior parietal lobe, caudate, putamen, pallidum, thalamus, and cerebellum. Additionally, we examined network topology of the motor network using graph theory. Among the currently depressed 55% had PmD (15% agitation, 29% retardation, and 11% concurrent agitation and retardation), while 16% of the remitted patients had PmD (8% retardation and 8% agitation). When compared with controls, currently depressed patients with PmD showed higher thalamo-cortical and pallido-cortical connectivity, but no network topology alterations. Currently depressed patients with retardation only had higher thalamo-cortical connectivity, while those with agitation had predominant higher pallido-cortical connectivity. Currently depressed patients without PmD showed higher thalamo-cortical, pallido-cortical, and cortico-cortical connectivity, as well as altered network topology compared to healthy controls. Remitted patients with PmD showed no differences in single connections but altered network topology, while remitted patients without PmD did not differ from healthy controls in any measure. We found evidence for compensatory increased cortico-cortical resting-state functional connectivity that may prevent psychomotor disturbance in current depression, but may perturb network topology. Agitation and retardation show specific connectivity signatures. Motor network topology is slightly altered in remitted patients arguing for persistent changes in depression. These alterations in functional connectivity may be addressed with non-invasive brain stimulation.</jats:p>
1000 Sacherschließung
lokal Female [MeSH]
lokal /692/53
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Nerve Net/physiopathology [MeSH]
lokal Depression/physiopathology [MeSH]
lokal Middle Aged [MeSH]
lokal Neural Pathways/physiopathology [MeSH]
lokal /59/36
lokal /692/699/476/1414
lokal Article
lokal Brain/physiopathology [MeSH]
lokal Depressive Disorder, Major/physiopathology [MeSH]
lokal Male [MeSH]
lokal Psychomotor Disorders/etiology [MeSH]
lokal Motor Cortex/physiopathology [MeSH]
lokal Psychomotor Agitation/physiopathology [MeSH]
lokal Brain Mapping/methods [MeSH]
lokal Psychomotor Disorders/physiopathology [MeSH]
lokal Magnetic Resonance Imaging/methods [MeSH]
lokal article
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6007-8668|https://orcid.org/0000-0003-4833-2197|https://orcid.org/0000-0001-9017-5119|https://orcid.org/0000-0002-8097-4483|https://frl.publisso.de/adhoc/uri/QWxleGFuZGVyLCBOaW5h|https://orcid.org/0000-0002-0526-8095|https://frl.publisso.de/adhoc/uri/RmxpbmtlbmZsw7xnZWwsIEtpcmE=|https://frl.publisso.de/adhoc/uri/R29sdGVybWFubiwgSmFuaWs=|https://orcid.org/0000-0001-8718-0128|https://orcid.org/0000-0001-6541-3795|https://frl.publisso.de/adhoc/uri/SmFtYWxhYmFkaSwgSGFtaWRyZXph|https://frl.publisso.de/adhoc/uri/SmFuc2VuLCBBbmRyZWFz|https://frl.publisso.de/adhoc/uri/TGVlaHIsIEVsaXNhYmV0aCBKLg==|https://orcid.org/0000-0003-2177-7161|https://orcid.org/0000-0002-0749-7473|https://frl.publisso.de/adhoc/uri/Tml0c2NoLCBSb2JlcnQ=|https://frl.publisso.de/adhoc/uri/U3RlaW4sIEZyZWRlcmlrZQ==|https://orcid.org/0000-0002-9837-0944|https://frl.publisso.de/adhoc/uri/VGV1dGVuYmVyZywgTGVh|https://frl.publisso.de/adhoc/uri/VGhpZWwsIEthdGhhcmluYQ==|https://orcid.org/0000-0003-4912-8307|https://frl.publisso.de/adhoc/uri/VXNlbWFubiwgUGF1bGE=|https://orcid.org/0000-0003-3759-1425|https://frl.publisso.de/adhoc/uri/RGFubmxvd3NraSwgVWRv|https://frl.publisso.de/adhoc/uri/S2lyY2hlciwgVGlsbw==|https://orcid.org/0000-0003-4026-3561
1000 Hinweis
  • DeepGreen-ID: 4d61521fd16049fabd5f5be7af380622 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. National Institute of Mental Health |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. The neural signature of psychomotor disturbance in depression
    The neural signature of psychomotor disturbance in depression
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Institute of Mental Health |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6501755.rdf
1000 Erstellt am 2025-02-05T14:40:32.612+0100
1000 Erstellt von 322
1000 beschreibt frl:6501755
1000 Zuletzt bearbeitet 2025-09-13T20:30:04.421+0200
1000 Objekt bearb. Sat Sep 13 20:30:04 CEST 2025
1000 Vgl. frl:6501755
1000 Oai Id
  1. oai:frl.publisso.de:frl:6501755 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source