Clinical characteristics and outcomes of COVID-19 patients with preexisting dementia: a large multicenter propensity-matched Brazilian cohort study

  1. CAMARGOS BICALHO, MARIA APARECIDA ORCID logo
  2. Romero Aliberti, Márlon Juliano ORCID logo
  3. DELFINO PEREIRA, POLIANNA ORCID logo
  4. Schulthais, Victor ORCID logo
  5. Rosa, Patryk ORCID logo
  6. Pires, Magda ORCID logo
  7. Ramos, Lucas Emanuel Ferreira ORCID logo
  8. Falangola Benjamin Bezerra, Adriana ORCID logo
  9. de Castro Feres, Ana Beatriz ORCID logo
  10. Gomides dos Reis Gomes, Angélica ORCID logo
  11. Bhering, Angelinda ORCID logo
  12. Pessoa, Bruno Porto ORCID logo
  13. Cândida Alves da Silva, Carla Thais ORCID logo
  14. Cimini, Christiane ORCID logo
  15. Suemoto, Claudia ORCID logo
  16. Dias, Cristiana ORCID logo
  17. Carazai, Daniela ORCID logo
  18. Ponce, Daniela ORCID logo
  19. Rios, Danyelle Romana Alves ORCID logo
  20. Manenti, Euler ORCID logo
  21. Anschau, Fernando ORCID logo
  22. Batista, Joanna d'Arc Lyra ORCID logo
  23. Coutinho de Alvarenga, Joice ORCID logo
  24. Avancini , Julia ORCID logo
  25. Mariot Zanellato, Julia ORCID logo
  26. MACHADO-RUGOLO, JULIANA ORCID logo
  27. Brasil Rauschel, Karen ORCID logo
  28. do Nascimento, Leticia ORCID logo
  29. Silva Monteiro Menezes, Luanna ORCID logo
  30. Carvalho de Oliveira, Lucas Moyses ORCID logo
  31. de Castro, Luís César ORCID logo
  32. Nasi, Luiz Antonio ORCID logo
  33. Carneiro, Marcelo ORCID logo
  34. Ferreira, Maria Angélica ORCID logo
  35. Frizzo de Godoy, Mariana ORCID logo
  36. Guimarães Júnior, Milton Henriques ORCID logo
  37. Ramos de Oliveira, Neimy ORCID logo
  38. Ziegelmann, Patricia ORCID logo
  39. Porto, Paula ORCID logo
  40. Mascarenhas Mendes, Paulo ORCID logo
  41. Gibson, Pedro ORCID logo
  42. Reis, Priscilla ORCID logo
  43. Francisco, Saionara Cristina ORCID logo
  44. Araújo, Silvia ORCID logo
  45. J. Avelino-Silva, Thiago ORCID logo
  46. Marcolino, Milena Soriano ORCID logo

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1000 Titel
  • Clinical characteristics and outcomes of COVID-19 patients with preexisting dementia: a large multicenter propensity-matched Brazilian cohort study
1000 Autor/in
  1. CAMARGOS BICALHO, MARIA APARECIDA |
  2. Romero Aliberti, Márlon Juliano |
  3. DELFINO PEREIRA, POLIANNA |
  4. Schulthais, Victor |
  5. Rosa, Patryk |
  6. Pires, Magda |
  7. Ramos, Lucas Emanuel Ferreira |
  8. Falangola Benjamin Bezerra, Adriana |
  9. de Castro Feres, Ana Beatriz |
  10. Gomides dos Reis Gomes, Angélica |
  11. Bhering, Angelinda |
  12. Pessoa, Bruno Porto |
  13. Cândida Alves da Silva, Carla Thais |
  14. Cimini, Christiane |
  15. Suemoto, Claudia |
  16. Dias, Cristiana |
  17. Carazai, Daniela |
  18. Ponce, Daniela |
  19. Rios, Danyelle Romana Alves |
  20. Manenti, Euler |
  21. Anschau, Fernando |
  22. Batista, Joanna d'Arc Lyra |
  23. Coutinho de Alvarenga, Joice |
  24. Avancini , Julia |
  25. Mariot Zanellato, Julia |
  26. MACHADO-RUGOLO, JULIANA |
  27. Brasil Rauschel, Karen |
  28. do Nascimento, Leticia |
  29. Silva Monteiro Menezes, Luanna |
  30. Carvalho de Oliveira, Lucas Moyses |
  31. de Castro, Luís César |
  32. Nasi, Luiz Antonio |
  33. Carneiro, Marcelo |
  34. Ferreira, Maria Angélica |
  35. Frizzo de Godoy, Mariana |
  36. Guimarães Júnior, Milton Henriques |
  37. Ramos de Oliveira, Neimy |
  38. Ziegelmann, Patricia |
  39. Porto, Paula |
  40. Mascarenhas Mendes, Paulo |
  41. Gibson, Pedro |
  42. Reis, Priscilla |
  43. Francisco, Saionara Cristina |
  44. Araújo, Silvia |
  45. J. Avelino-Silva, Thiago |
  46. Marcolino, Milena Soriano |
1000 Verlag
  • BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-01-05
1000 Erschienen in
1000 Quellenangabe
  • 24(1):25
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12877-023-04494-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770897/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Although dementia has emerged as an important risk factor for severe SARS-CoV-2 infection, results on COVID-19-related complications and mortality are not consistent. We examined the clinical presentations and outcomes of COVID-19 in a multicentre cohort of in-hospital patients, comparing those with and without dementia.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This retrospective observational study comprises COVID-19 laboratory-confirmed patients aged ≥ 60 years admitted to 38 hospitals from 19 cities in Brazil. Data were obtained from electronic hospital records. A propensity score analysis was used to match patients with and without dementia (up to 3:1) according to age, sex, comorbidities, year, and hospital of admission. Our primary outcome was in-hospital mortality. We also assessed admission to the intensive care unit (ICU), invasive mechanical ventilation (IMV), kidney replacement therapy (KRT), sepsis, nosocomial infection, and thromboembolic events.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Among 1,556 patients included in the study, 405 (4.5%) had a diagnosis of dementia and 1,151 were matched controls. When compared to matched controls, patients with dementia had a lower frequency of dyspnoea, cough, myalgia, headache, ageusia, and anosmia; and higher frequency of fever and delirium. They also had a lower frequency of ICU admission (32.7% vs. 47.1%, <jats:italic>p</jats:italic> &lt; 0.001) and shorter ICU length of stay (7 vs. 9 days, <jats:italic>p</jats:italic> &lt; 0.026), and a lower frequency of sepsis (17% vs. 24%, <jats:italic>p</jats:italic> = 0.005), KRT (6.4% vs. 13%, <jats:italic>p</jats:italic> &lt; 0.001), and IVM (4.6% vs. 9.8%, <jats:italic>p</jats:italic> = 0.002). There were no differences in hospital mortality between groups.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Clinical manifestations of COVID-19 differ between older inpatients with and without dementia. We observed that dementia alone could not explain the higher short-term mortality following severe COVID-19. Therefore, clinicians should consider other risk factors such as acute morbidity severity and baseline frailty when evaluating the prognosis of older adults with dementia hospitalised with COVID-19.</jats:p> </jats:sec>
1000 Sacherschließung
lokal COVID-19/diagnosis [MeSH]
lokal Dementia
lokal Sepsis [MeSH]
gnd 1206347392 COVID-19
lokal Brazil
lokal Aged [MeSH]
lokal Retrospective study
lokal Humans [MeSH]
lokal Dementia/diagnosis [MeSH]
lokal Severity
lokal COVID-19
lokal COVID-19/complications [MeSH]
lokal Brazil/epidemiology [MeSH]
lokal Prognosis
lokal Cohort Studies [MeSH]
lokal Multicentre study
lokal Dementia/therapy [MeSH]
lokal Hospital mortality
lokal Hospitalisation
lokal COVID-19/epidemiology [MeSH]
lokal Dementia/epidemiology [MeSH]
lokal SARS-CoV-2 [MeSH]
lokal Research Article
lokal Inpatients [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6298-9377|https://orcid.org/0000-0001-7467-1745|https://orcid.org/0000-0003-2406-6576|https://orcid.org/0000-0002-9058-2803|https://orcid.org/0000-0002-1370-9073|https://orcid.org/0000-0003-3312-4002|https://orcid.org/0000-0001-7844-0581|https://orcid.org/0000-0002-5278-3727|https://orcid.org/0000-0002-6728-8251|https://orcid.org/0000-0002-4568-0738|https://orcid.org/0000-0002-7391-1951|https://orcid.org/0000-0002-4212-519X|https://orcid.org/0000-0003-1726-4494|https://orcid.org/0000-0002-1973-1343|https://orcid.org/0000-0002-5942-4778|https://orcid.org/0000-0002-3683-220X|https://orcid.org/0000-0001-7856-4154|https://orcid.org/0000-0002-6178-6938|https://orcid.org/0000-0001-6377-241X|https://orcid.org/0000-0003-1592-4727|https://orcid.org/0000-0002-2657-5406|https://orcid.org/0000-0002-3703-2845|https://orcid.org/0000-0003-3536-7112|https://orcid.org/0000-0003-3558-7721|https://orcid.org/0000-0002-8330-3060|https://orcid.org/0000-0003-3984-4959|https://orcid.org/0000-0002-6362-1889|https://orcid.org/0000-0003-3806-1039|https://orcid.org/0000-0002-6621-3338|https://orcid.org/0009-0004-9485-2147|https://orcid.org/0000-0003-2379-0167|https://orcid.org/0000-0002-7069-5827|https://orcid.org/0000-0003-3603-1987|https://orcid.org/0000-0003-0961-524X|https://orcid.org/0000-0002-6631-8826|https://orcid.org/0000-0002-2127-8015|https://orcid.org/0000-0001-5408-9459|https://orcid.org/0000-0002-2851-2011|https://orcid.org/0000-0002-2037-0792|https://orcid.org/0000-0003-4194-0026|https://orcid.org/0000-0002-9663-4985|https://orcid.org/0000-0002-0340-9464|https://orcid.org/0000-0002-9655-6294|https://orcid.org/0000-0003-4782-5440|https://orcid.org/0000-0001-9347-0519|https://orcid.org/0000-0003-4278-3771
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