The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning

  1. Kleinbongard, Petra ORCID logo
  2. Galán-Arriola, Carlos ORCID logo
  3. Badimon, Lina ORCID logo
  4. Crisostomo, Verónica ORCID logo
  5. Giricz, Zoltán ORCID logo
  6. Gyöngyösi, Mariann ORCID logo
  7. Heusch, Gerd ORCID logo
  8. Ibanez, Borja ORCID logo
  9. Kiss, Attila ORCID logo
  10. de Kleijn, Dominique ORCID logo
  11. Podesser, Bruno ORCID logo
  12. Ramirez Carracedo, Rafael ORCID logo
  13. Rodriguez-Sinovas, Antonio ORCID logo
  14. Ruiz Meana, Marisol ORCID logo
  15. Sanchez Margallo, Francisco Miguel ORCID logo
  16. Vilahur, Gemma ORCID logo
  17. Zamorano, José Luis ORCID logo
  18. Zaragoza, Carlos ORCID logo
  19. Ferdinandy, Peter ORCID logo
  20. Hausenloy, Derek ORCID logo

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1000 Titel
  • The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
1000 Autor/in
  1. Kleinbongard, Petra |
  2. Galán-Arriola, Carlos |
  3. Badimon, Lina |
  4. Crisostomo, Verónica |
  5. Giricz, Zoltán |
  6. Gyöngyösi, Mariann |
  7. Heusch, Gerd |
  8. Ibanez, Borja |
  9. Kiss, Attila |
  10. de Kleijn, Dominique |
  11. Podesser, Bruno |
  12. Ramirez Carracedo, Rafael |
  13. Rodriguez-Sinovas, Antonio |
  14. Ruiz Meana, Marisol |
  15. Sanchez Margallo, Francisco Miguel |
  16. Vilahur, Gemma |
  17. Zamorano, José Luis |
  18. Zaragoza, Carlos |
  19. Ferdinandy, Peter |
  20. Hausenloy, Derek |
1000 Verlag
  • Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-10-18
1000 Erschienen in
1000 Quellenangabe
  • 119(6):893-909
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-024-01083-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628588/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Numerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies. However, their translation for the benefit of patients with acute myocardial infarction (AMI) has been largely disappointing. One reason for the lack of translation is the lack of rigor and reproducibility in pre-clinical studies. To address this, we have established the European IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) pig AMI network with centralized randomization and blinded core laboratory IS analysis and validated the network with ischemic preconditioning (IPC) as a positive control. Ten sites in the COST Innovators Grant (IG16225) network participated in the IMPACT network. Three sites were excluded from the final analysis through quality control of infarct images and use of pre-defined exclusion criteria. Using a centrally generated randomization list, pigs were allocated to myocardial ischemia/reperfusion (I/R, <jats:italic>N</jats:italic> = 5/site) or IPC + I/R (<jats:italic>N</jats:italic> = 5/site). The primary endpoint was IS [% area-at-risk (AAR)], as quantified by triphenyl-tetrazolium-chloride (TTC) staining in a centralized, blinded core laboratory (5 sites), or IS [% left-ventricular mass (LV)], as quantified by a centralized, blinded cardiac magnetic resonance (CMR) core laboratory (2 sites). In pooled analyses, IPC significantly reduced IS when compared to I/R (57 ± 14 versus 32 ± 19 [%AAR] <jats:italic>N</jats:italic> = 25 pigs/group; <jats:italic>p</jats:italic> &lt; 0.001; 25 ± 13 versus 14 ± 8 [%LV]; <jats:italic>N</jats:italic> = 10 pigs/group; <jats:italic>p</jats:italic> = 0.021). In site-specific analyses, in 4 of the 5 sites, IS was significantly reduced by IPC when compared to I/R when quantified by TTC and in 1 of 2 sites when quantified by CMR. A pig AMI multicenter European network with centralized randomization and core blinded IS analysis was established and validated with the aim to improve the reproducibility of cardioprotective interventions in pre-clinical studies and the translation of cardioprotection for patient benefit.</jats:p>
1000 Sacherschließung
lokal Myocardial Infarction/therapy [MeSH]
lokal Female [MeSH]
lokal Myocardial Reperfusion Injury/pathology [MeSH]
lokal Swine [MeSH]
lokal Pig
lokal Myocardial Infarction/prevention
lokal Ischemic Preconditioning, Myocardial/methods [MeSH]
lokal Original Contribution
lokal Randomized-controlled trial
lokal Myocardial Infarction/pathology [MeSH]
lokal Animals [MeSH]
lokal Acute myocardial infarction
lokal Ischemic preconditioning
lokal Myocardial Reperfusion Injury/prevention
lokal Male [MeSH]
lokal Reproducibility of Results [MeSH]
lokal Multicenter network
lokal Disease Models, Animal [MeSH]
lokal Ischemia/reperfusion injury
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3576-3772|https://orcid.org/0000-0001-7403-8974|https://orcid.org/0000-0002-9162-2459|https://orcid.org/0000-0003-1740-7029|https://orcid.org/0000-0003-2036-8665|https://orcid.org/0000-0002-7083-2107|https://orcid.org/0000-0001-7078-4160|https://orcid.org/0000-0002-5036-254X|https://orcid.org/0000-0003-4652-1998|https://orcid.org/0000-0003-2714-2140|https://orcid.org/0000-0002-4641-7202|https://orcid.org/0000-0002-8391-2245|https://orcid.org/0000-0003-2930-8773|https://orcid.org/0000-0002-4067-4638|https://orcid.org/0000-0003-2138-988X|https://orcid.org/0000-0002-2828-8873|https://orcid.org/0000-0002-0487-1749|https://orcid.org/0000-0002-1706-8592|https://orcid.org/0000-0002-6424-6806|https://orcid.org/0000-0003-0729-4956
1000 Hinweis
  • DeepGreen-ID: 65b97ba7d282410fb61f6fbe61ad649c ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. Severo Ochoa Center of Excellence |
  2. Duke-NUS Signature Research Programme |
  3. Ministry for Innovation and Technology in Hungary |
  4. Hungarian National Scientific Research Fund |
  5. Instituto de Salud Carlos III |
  6. Centro Nacional de Investigaciones Cardiovasculares |
  7. Ministerio de Ciencia e Innovación |
  8. Pro CNIC Foundation |
  9. Deutsche Forschungsgemeinschaft |
  10. European Union COST Action METAHEART |
  11. Ludwig Boltzmann Gesellschaft |
  12. Universitätsklinikum Essen |
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    1000 Förderer Severo Ochoa Center of Excellence |
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    1000 Förderer Duke-NUS Signature Research Programme |
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    1000 Förderer Ministry for Innovation and Technology in Hungary |
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    1000 Förderer Hungarian National Scientific Research Fund |
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    1000 Förderer Instituto de Salud Carlos III |
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    1000 Förderer Centro Nacional de Investigaciones Cardiovasculares |
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    1000 Förderer Ministerio de Ciencia e Innovación |
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    1000 Förderer Pro CNIC Foundation |
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    1000 Förderer Deutsche Forschungsgemeinschaft |
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    1000 Förderer European Union COST Action METAHEART |
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    1000 Förderer Ludwig Boltzmann Gesellschaft |
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    1000 Förderer Universitätsklinikum Essen |
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1000 Objektart article
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1000 Erstellt am 2025-02-06T13:20:06.743+0100
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