Download
15010_2023_Article_2070.pdf 1,26MB
WeightNameValue
1000 Titel
  • Pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ-Cohort
1000 Autor/in
  1. Schleenvoigt, Benjamin T. |
  2. Ankert, Juliane |
  3. Barten-Neiner, Grit |
  4. Voit, Florian |
  5. Suttorp, Norbert |
  6. Boesecke, Christoph |
  7. Hoffmann, Christian |
  8. Stolz, Daiana |
  9. Pletz, Mathias W. |
  10. Rohde, Gernot |
  11. Witzenrath, Martin |
  12. Panning, Marcus |
  13. Essig, Andreas |
  14. Rupp, Jan |
  15. Degen, Olaf |
  16. Stephan, Christoph |
  17. for the CAPNETZ Study Group |
  18. Dreher, M. |
  19. Cornelissen, C. |
  20. Knüppel, W. |
  21. Creutz, P. |
  22. Mikolajewska, A. |
  23. le Claire, A. |
  24. Benzke, M. |
  25. Bauer, T. |
  26. Krieger, D. |
  27. Prediger, M. |
  28. Schmager, S. |
  29. Kolditz, M. |
  30. Schulte-Hubbert, B. |
  31. Langner, S. |
  32. Hüfner, A. |
  33. Welte, T. |
  34. Freise, J. |
  35. Nawrocki, M. |
  36. Fuge, I. |
  37. Freise, J. |
  38. Naim, J. |
  39. Kröner, W. |
  40. Illig, T. |
  41. Klopp, N. |
  42. Kroegel, C. |
  43. Moeser, A. |
  44. Bahrs, C. |
  45. Drömann, D. |
  46. Parschke, P. |
  47. Franzen, K. |
  48. Käding, N. |
  49. Wouters, M. |
  50. Walraven, K. |
  51. Braeken, D. |
  52. Buschmann, H. |
  53. Zaruchas, A. |
  54. Schaberg, T. |
  55. Hering, I. |
  56. Albrich, W. |
  57. Waldeck, F. |
  58. Rassouli, F. |
  59. Baldesberger, S. |
  60. Wallner, M. |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-07-09
1000 Erschienen in
1000 Quellenangabe
  • 52(1):129-137
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s15010-023-02070-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811115/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Objectives</jats:title> <jats:p>The objective of this study was to identify the pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH), and to compare it with a matched HIV negative group in order to reassess therapeutic strategies for PLWH.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Seventy-three (n = 73) PLWH (median CD4 3–6 months before CAP: 515/µl; SD 309) with community acquired pneumonia (CAP) were matched with 218 HIV-negative CAP controls in a prospective study design. Pathogen identifications used blood culture, samples from the upper and lower respiratory tract (culture and multiplex PCR) and urinary pneumococcal and legionella antigen test.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Although the vaccination rate among PLWH with CAP was significantly higher (pneumococcal vaccination: 27.4 vs. 8.3%, p &lt; 0.001; influenza vaccination: 34.2 vs. 17.4%, p = 0.009), pneumococci were found most frequently as pathogen among both PLWH (n = 19/21.3%) and controls (n = 34/17.2%; p = 0.410), followed by <jats:italic>Haemophilus influenzae</jats:italic> (PLWH, n = 12/13.5%, vs. controls, n = 25 / 12.6%; p = 0.850). <jats:italic>Staphylococcus aureus</jats:italic> was found equally in 20.2 and 19.2% in PLWH and controls, but infection or colonization could not be distinguished. Mortality during 6-month follow-up was significantly higher for PLWH (5/73, or 6.8%) versus controls (3/218, or 1.4%), however with lower case numbers than previously reported. Typical HIV-associated pathogens such as <jats:italic>Pneumocystis jirovecii</jats:italic> were found only exceptionally.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Our study underscores the persistent clinical burden of CAP for PLWH. From pathogen perspective, empirical antibiotic treatment for CAP in PLWH on antiretroviral therapy should cover pneumococci and <jats:italic>Haemophilus influenzae</jats:italic> and may be adopted from valid common recommendations<jats:italic>.</jats:italic></jats:p> </jats:sec>
1000 Sacherschließung
lokal Streptococcus pneumoniae [MeSH]
lokal HIV Infections/complications [MeSH]
lokal Anti-Bacterial Agents/therapeutic use [MeSH]
lokal Haemophilus Infections/drug therapy [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal HIV
lokal Community acquired pneumonia
lokal Haemophilus influenzae [MeSH]
lokal CAP
lokal Community-Acquired Infections/drug therapy [MeSH]
lokal HIV Infections/epidemiology [MeSH]
lokal Empirical antibiotic treatment
lokal HIV Infections/drug therapy [MeSH]
lokal Research
lokal Pneumonia
lokal PLWH
lokal Community-Acquired Infections/epidemiology [MeSH]
lokal Pneumonia, Bacterial/epidemiology [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2NobGVlbnZvaWd0LCBCZW5qYW1pbiBULg==|https://frl.publisso.de/adhoc/uri/QW5rZXJ0LCBKdWxpYW5l|https://frl.publisso.de/adhoc/uri/QmFydGVuLU5laW5lciwgR3JpdA==|https://frl.publisso.de/adhoc/uri/Vm9pdCwgRmxvcmlhbg==|https://frl.publisso.de/adhoc/uri/U3V0dG9ycCwgTm9yYmVydA==|https://frl.publisso.de/adhoc/uri/Qm9lc2Vja2UsIENocmlzdG9waA==|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/uri/U3RvbHosIERhaWFuYQ==|https://frl.publisso.de/adhoc/uri/UGxldHosIE1hdGhpYXMgVy4=|https://frl.publisso.de/adhoc/uri/Um9oZGUsIEdlcm5vdA==|https://frl.publisso.de/adhoc/uri/V2l0emVucmF0aCwgTWFydGlu|https://frl.publisso.de/adhoc/uri/UGFubmluZywgTWFyY3Vz|https://frl.publisso.de/adhoc/uri/RXNzaWcsIEFuZHJlYXM=|https://frl.publisso.de/adhoc/uri/UnVwcCwgSmFu|https://frl.publisso.de/adhoc/uri/RGVnZW4sIE9sYWY=|https://frl.publisso.de/adhoc/uri/U3RlcGhhbiwgQ2hyaXN0b3Bo|https://frl.publisso.de/adhoc/uri/Zm9yIHRoZSBDQVBORVRaIFN0dWR5IEdyb3Vw|https://frl.publisso.de/adhoc/uri/RHJlaGVyLCBNLg==|https://frl.publisso.de/adhoc/uri/Q29ybmVsaXNzZW4sIEMu|https://frl.publisso.de/adhoc/uri/S27DvHBwZWwsIFcu|https://frl.publisso.de/adhoc/uri/Q3JldXR6LCBQLg==|https://frl.publisso.de/adhoc/uri/TWlrb2xhamV3c2thLCBBLg==|https://frl.publisso.de/adhoc/uri/bGUgQ2xhaXJlLCBBLg==|https://frl.publisso.de/adhoc/uri/QmVuemtlLCBNLg==|https://frl.publisso.de/adhoc/uri/QmF1ZXIsIFQu|https://frl.publisso.de/adhoc/uri/S3JpZWdlciwgRC4=|https://frl.publisso.de/adhoc/uri/UHJlZGlnZXIsIE0u|https://frl.publisso.de/adhoc/uri/U2NobWFnZXIsIFMu|https://frl.publisso.de/adhoc/uri/S29sZGl0eiwgTS4=|https://frl.publisso.de/adhoc/uri/U2NodWx0ZS1IdWJiZXJ0LCBCLg==|https://frl.publisso.de/adhoc/uri/TGFuZ25lciwgUy4=|https://frl.publisso.de/adhoc/uri/SMO8Zm5lciwgQS4=|https://frl.publisso.de/adhoc/uri/V2VsdGUsIFQu|https://frl.publisso.de/adhoc/uri/RnJlaXNlLCBKLg==|https://frl.publisso.de/adhoc/uri/TmF3cm9ja2ksIE0u|https://frl.publisso.de/adhoc/uri/RnVnZSwgSS4=|https://frl.publisso.de/adhoc/uri/RnJlaXNlLCBKLg==|https://frl.publisso.de/adhoc/uri/TmFpbSwgSi4=|https://frl.publisso.de/adhoc/uri/S3LDtm5lciwgVy4=|https://frl.publisso.de/adhoc/uri/SWxsaWcsIFQu|https://frl.publisso.de/adhoc/uri/S2xvcHAsIE4u|https://frl.publisso.de/adhoc/uri/S3JvZWdlbCwgQy4=|https://frl.publisso.de/adhoc/uri/TW9lc2VyLCBBLg==|https://frl.publisso.de/adhoc/uri/QmFocnMsIEMu|https://frl.publisso.de/adhoc/uri/RHLDtm1hbm4sIEQu|https://frl.publisso.de/adhoc/uri/UGFyc2Noa2UsIFAu|https://frl.publisso.de/adhoc/uri/RnJhbnplbiwgSy4=|https://frl.publisso.de/adhoc/uri/S8OkZGluZywgTi4=|https://frl.publisso.de/adhoc/uri/V291dGVycywgTS4=|https://frl.publisso.de/adhoc/uri/V2FscmF2ZW4sIEsu|https://frl.publisso.de/adhoc/uri/QnJhZWtlbiwgRC4=|https://frl.publisso.de/adhoc/uri/QnVzY2htYW5uLCBILg==|https://frl.publisso.de/adhoc/uri/WmFydWNoYXMsIEEu|https://frl.publisso.de/adhoc/uri/U2NoYWJlcmcsIFQu|https://frl.publisso.de/adhoc/uri/SGVyaW5nLCBJLg==|https://frl.publisso.de/adhoc/uri/QWxicmljaCwgVy4=|https://frl.publisso.de/adhoc/uri/V2FsZGVjaywgRi4=|https://frl.publisso.de/adhoc/uri/UmFzc291bGksIEYu|https://frl.publisso.de/adhoc/uri/QmFsZGVzYmVyZ2VyLCBTLg==|https://frl.publisso.de/adhoc/uri/V2FsbG5lciwgTS4=
1000 Hinweis
  • DeepGreen-ID: b31d04410dee476c87e660e3447a845f ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. German Federal Ministry of Education and Research grant |
  2. Deutsches Zentrum für Lungenforschung |
  3. Deutsches Zentrum für Lungenforschung |
  4. Friedrich-Schiller-Universität Jena |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research grant |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsches Zentrum für Lungenforschung |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Deutsches Zentrum für Lungenforschung |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Friedrich-Schiller-Universität Jena |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6508184.rdf
1000 Erstellt am 2025-02-06T16:37:22.521+0100
1000 Erstellt von 322
1000 beschreibt frl:6508184
1000 Zuletzt bearbeitet 2025-09-14T09:53:44.565+0200
1000 Objekt bearb. Sun Sep 14 09:53:44 CEST 2025
1000 Vgl. frl:6508184
1000 Oai Id
  1. oai:frl.publisso.de:frl:6508184 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source