The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype

  1. Ziegler, Philipp
  2. Hartkopf, Andreas D.
  3. Wallwiener, Markus
  4. Häberle, Lothar
  5. Kolberg, Hans-Christian
  6. Hadji, Peyman
  7. Tesch, Hans
  8. Ettl, Johannes
  9. Lüftner, Diana
  10. Müller, Volkmar
  11. Michel, Laura L.
  12. Belleville, Erik
  13. Wimberger, Pauline
  14. Hielscher, Carsten
  15. Huebner, Hanna
  16. Uhrig, Sabrina
  17. Wurmthaler, Lena A.
  18. Hack, Carolin C.
  19. Mundhenke, Christoph
  20. Kurbacher, Christian
  21. Fasching, Peter A.
  22. Wuerstlein, Rachel
  23. Untch, Michael
  24. Janni, Wolfgang
  25. Taran, Florin-Andrei
  26. Lux, Michael P.
  27. Wallwiener, Diethelm
  28. Brucker, Sara Y.
  29. Fehm, Tanja N.
  30. Schneeweiss, Andreas
  31. Goossens, Chloë

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1000 Titel
  • The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype
1000 Autor/in
  1. Ziegler, Philipp |
  2. Hartkopf, Andreas D. |
  3. Wallwiener, Markus |
  4. Häberle, Lothar |
  5. Kolberg, Hans-Christian |
  6. Hadji, Peyman |
  7. Tesch, Hans |
  8. Ettl, Johannes |
  9. Lüftner, Diana |
  10. Müller, Volkmar |
  11. Michel, Laura L. |
  12. Belleville, Erik |
  13. Wimberger, Pauline |
  14. Hielscher, Carsten |
  15. Huebner, Hanna |
  16. Uhrig, Sabrina |
  17. Wurmthaler, Lena A. |
  18. Hack, Carolin C. |
  19. Mundhenke, Christoph |
  20. Kurbacher, Christian |
  21. Fasching, Peter A. |
  22. Wuerstlein, Rachel |
  23. Untch, Michael |
  24. Janni, Wolfgang |
  25. Taran, Florin-Andrei |
  26. Lux, Michael P. |
  27. Wallwiener, Diethelm |
  28. Brucker, Sara Y. |
  29. Fehm, Tanja N. |
  30. Schneeweiss, Andreas |
  31. Goossens, Chloë |
1000 Verlag BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-10-16
1000 Erschienen in
1000 Quellenangabe
  • 24(1):1284
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12885-024-13038-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481816/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Although adequate physical activity has been shown to be beneficial in early breast cancer, evidence in metastatic breast cancer is sparse and contradictory, which could be related to distinct effects of physical activity on the different molecular cancer subtypes. Therefore, we here evaluated the effect of physical activity on progression-free and overall survival (PFS, OS) in metastatic breast cancer, specifically looking at molecular subtypes.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>International Physical Activity Questionnaire (IPAQ) questionnaires, filled out by patients enrolled in the prospective PRAEGNANT registry (NCT02338167; n = 1,270) were used to calculate metabolic equivalent task (MET) minutes, which were subsequently categorized into low (n = 138), moderate (n = 995) or high IPAQ categories (n = 137). Cox regression analyses were used to evaluate the impact of IPAQ categories and its interaction with molecular subtypes on PFS and OS.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Patient and tumor characteristics were equally distributed across IPAQ categories. HER2pos, HRpos and TNBC were present in 23.1%, 65.7% and 11.2% of patients, respectively. IPAQ scores did not have an impact on PFS and OS in addition to established prognostic factors, either overall or in particular molecular subtypes (PFS: p = 0.33 and OS: p = 0.08, likelihood ratio test). Exploratory analyses showed higher overall survival rates for high IPAQ categories compared to low/moderate IPAQ categories in luminal B-like breast cancer.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Self-reported physical activity using the IPAQ questionnaire did not significantly affect PFS or OS in patients suffering from metastatic breast cancer. Nevertheless, some hypothesis-generating differences between molecular subtypes could be observed, which may be interesting to evaluate further.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Surveys and Questionnaires [MeSH]
lokal Female [MeSH]
lokal Molecular subtype
lokal Metastatic breast cancer
lokal Aged [MeSH]
lokal Adult [MeSH]
lokal Receptor, ErbB-2/metabolism [MeSH]
lokal Humans [MeSH]
lokal Neoplasm Metastasis [MeSH]
lokal Prospective Studies [MeSH]
lokal Progression-Free Survival [MeSH]
lokal Middle Aged [MeSH]
lokal Diet and physical activity during and after cancer treatment
lokal IPAQ
lokal Research
lokal Physical activity
lokal Prognosis [MeSH]
lokal Breast Neoplasms/mortality [MeSH]
lokal Breast Neoplasms/pathology [MeSH]
lokal Registries [MeSH]
lokal Exercise [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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