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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p><jats:italic>Helicobacter pylori</jats:italic> colonizes the human stomach and may affect the inflammatory response, hormone production related to energy regulation, and gastrointestinal microbiota composition. Previous studies have explored a potential association between <jats:italic>H. pylori</jats:italic> infection and pediatric obesity with varying results. Considering the immunomodulatory effects of early-life infection with <jats:italic>H. pylori</jats:italic> that can confer beneficial effects, we hypothesized that we would find an inverse relationship between <jats:italic>H. pylori</jats:italic> seropositivity and obesity among Danish children and adolescents.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We assessed <jats:italic>H. pylori</jats:italic> seroprevalence in 713 subjects from an obesity clinic cohort and 990 subjects from a population-based cohort, aged 6 to 19 years, and examined its association with obesity and other cardiometabolic risk factors.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>No association was found between <jats:italic>H. pylori</jats:italic> and body mass index standard deviation score (BMI SDS). <jats:italic>H. pylori</jats:italic> seropositivity was, however, significantly associated with higher fasting plasma glucose levels and the prevalence of hyperglycemia.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>While we did not find an association between <jats:italic>H. pylori</jats:italic> seropositivity and BMI SDS, we observed a significant association with higher fasting plasma glucose levels and increased prevalence of hyperglycemia, suggesting that <jats:italic>H. pylori</jats:italic> infection may contribute to impaired glucose regulation in Danish children and adolescents.
</jats:p>
</jats:sec><jats:sec>
<jats:title>Graphical abstract</jats:title>
</jats:sec>
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1000
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Hinweis
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DeepGreen-ID: ee908f33e4cc4f0c9f1246737746460a ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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