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1000
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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>Physical exercise is crucial for healthy aging and plays a decisive role in the prevention of atherosclerotic cardiovascular disease (ASCVD). A higher level of cardiorespiratory fitness (CRF) in the elderly is associated with lower cardiovascular and all-cause mortality. This study investigated the association of CRF level with vascular function and cardiovascular risk factors in the elderly.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We examined 79 apparently healthy and physically active subjects aged > 55 years (64 ± 4 years). Cardiovascular functional parameters assessed included brachial and central blood pressure (BP), pulse wave velocity (PWV), augmentation index (Aix), and ankle-brachial index. Sonography of the common carotid artery was performed. CRF level was determined by a cardiopulmonary exercise test, and everyday activity was quantified with an accelerometer.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>All participants had a higher CRF level than the reported age-specific normative values. Twenty-nine subjects had subclinical atherosclerosis of the common carotid artery. Compared with participants without atherosclerosis, they were older (<jats:italic>p</jats:italic> = 0.007), displayed higher brachial systolic BP (<jats:italic>p</jats:italic> = 0.006), and higher central systolic BP (<jats:italic>p</jats:italic> = 0.014). Lower brachial (<jats:italic>p</jats:italic> = 0.036) and central (<jats:italic>p</jats:italic> = 0.003) systolic BP, lower PWV (<jats:italic>p</jats:italic> = 0.004), lower Aix (<jats:italic>p</jats:italic> < 0.001), lower body fat percentage (< 0.001), and lower LDL cholesterol (<jats:italic>p</jats:italic> = 0.005) were associated with a higher CRF level.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>In this cohort of healthy and physically active individuals, subjects with subclinical atherosclerosis displayed higher systolic brachial and central BP. A higher CRF level was associated with enhanced vascular function, consistent with an influence of CRF on both BP and vascular function in the elderly.</jats:p>
</jats:sec>
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1000
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Hinweis
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DeepGreen-ID: 075b08a84eba4d16a33389cf80316e2c ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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