Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration

  1. Galofré, Juan C ORCID logo
  2. Díez, Juan J. ORCID logo
  3. Attanasio, Roberto ORCID logo
  4. Nagy, Endre ORCID logo
  5. Negro, Roberto ORCID logo
  6. papini, enrico ORCID logo
  7. Perros, Petros ORCID logo
  8. Žarković, Miloš ORCID logo
  9. Akarsu, Ersin ORCID logo
  10. ALEVIZAKI, MARIA ORCID logo
  11. ayvaz, goksun ORCID logo
  12. Bednarczuk, Tomasz ORCID logo
  13. Nedeljkovic Beleslin, Biljana ORCID logo
  14. Berta, Eszter ORCID logo
  15. Bodor, Miklos ORCID logo
  16. Borissova, Anna-Maria ORCID logo
  17. Boyanov, Mihail ORCID logo
  18. Buffet, Camille ORCID logo
  19. Burlacu, Maria-Cristina ORCID logo
  20. Dobnig, Harald ORCID logo
  21. Fadeev, Valentin ORCID logo
  22. Field, Benjamin ORCID logo
  23. Fliers, Eric ORCID logo
  24. Fuehrer, Dagmar ORCID logo
  25. Hakala, Tommi ORCID logo
  26. Jiskra, Jan ORCID logo
  27. Kopp, Peter A ORCID logo
  28. Krebs, Michael ORCID logo
  29. Kršek, Michal ORCID logo
  30. Kuzma, Martin ORCID logo
  31. Lantz, Mikael ORCID logo
  32. Lazurova, Ivica ORCID logo
  33. Leenhardt, Laurence ORCID logo
  34. Luchytskyi, Vitalii ORCID logo
  35. Puga, Francisca ORCID logo
  36. McGowan, Anne ORCID logo
  37. Metso, Saara ORCID logo
  38. Moran, Carla ORCID logo
  39. Моргунова, Татьяна ORCID logo
  40. Niculescu, Dan ORCID logo
  41. Perić, Božidar ORCID logo
  42. Planck, Tereza ORCID logo
  43. Poiana, Catalina ORCID logo
  44. Robenshtok, Eyal ORCID logo
  45. Rosselet, Patrick-Olivier ORCID logo
  46. Ruchala, Marek ORCID logo
  47. Ryom Riis, Kamilla ORCID logo
  48. Shepelkevich, Alla ORCID logo
  49. Tronko, M ORCID logo
  50. Unuane, David ORCID logo
  51. Vardarli, Irfan ORCID logo
  52. Visser, W. Edward ORCID logo
  53. Vryonidou, Andromachi ORCID logo
  54. Younes, Younes R. ORCID logo
  55. Hegedüs, Laszlo ORCID logo

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1000 Titel
  • Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration
1000 Autor/in
  1. Galofré, Juan C |
  2. Díez, Juan J. |
  3. Attanasio, Roberto |
  4. Nagy, Endre |
  5. Negro, Roberto |
  6. papini, enrico |
  7. Perros, Petros |
  8. Žarković, Miloš |
  9. Akarsu, Ersin |
  10. ALEVIZAKI, MARIA |
  11. ayvaz, goksun |
  12. Bednarczuk, Tomasz |
  13. Nedeljkovic Beleslin, Biljana |
  14. Berta, Eszter |
  15. Bodor, Miklos |
  16. Borissova, Anna-Maria |
  17. Boyanov, Mihail |
  18. Buffet, Camille |
  19. Burlacu, Maria-Cristina |
  20. Dobnig, Harald |
  21. Fadeev, Valentin |
  22. Field, Benjamin |
  23. Fliers, Eric |
  24. Fuehrer, Dagmar |
  25. Hakala, Tommi |
  26. Jiskra, Jan |
  27. Kopp, Peter A |
  28. Krebs, Michael |
  29. Kršek, Michal |
  30. Kuzma, Martin |
  31. Lantz, Mikael |
  32. Lazurova, Ivica |
  33. Leenhardt, Laurence |
  34. Luchytskyi, Vitalii |
  35. Puga, Francisca |
  36. McGowan, Anne |
  37. Metso, Saara |
  38. Moran, Carla |
  39. Моргунова, Татьяна |
  40. Niculescu, Dan |
  41. Perić, Božidar |
  42. Planck, Tereza |
  43. Poiana, Catalina |
  44. Robenshtok, Eyal |
  45. Rosselet, Patrick-Olivier |
  46. Ruchala, Marek |
  47. Ryom Riis, Kamilla |
  48. Shepelkevich, Alla |
  49. Tronko, M |
  50. Unuane, David |
  51. Vardarli, Irfan |
  52. Visser, W. Edward |
  53. Vryonidou, Andromachi |
  54. Younes, Younes R. |
  55. Hegedüs, Laszlo |
1000 Verlag
  • Springer International Publishing
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-06-15
1000 Erschienen in
1000 Quellenangabe
  • 48(1):201-212
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s40618-024-02409-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729071/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Purpose</jats:title> <jats:p>The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as reflected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European thyroid specialists.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Specialists from 28 countries were invited to a survey via professional organisations. The relevant question was whether “<jats:italic>Thyroid hormones may be indicated in biochemically euthyroid patients with obesity resistant to lifestyle interventions”</jats:italic>.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Of 17,232 invitations 5695 responses were received (33% valid response rate; 65% women; 90% endocrinologists). Of these, 290 (5.1%) stated that TH may be indicated as treatment for obesity in euthyroid patients. This view was commoner among non-endocrinologists (8.7% vs. 4.7%, p &lt; 0.01), private practice (6.5% vs. 4.5%, p &lt; 0.01), and varied geographically (Eastern Europe, 7.3%; Southern Europe, 4.8%; Western Europe, 2.7%; and Northern Europe, 2.5%). Respondents from Northern and Western Europe were less likely to use TH than those from Eastern Europe (p &lt; 0.01). Gross national income (GNI) correlated inversely with this view (OR 0.97, CI: 0.96–0.97; p &lt; 0.001). Having national guidelines on hypothyroidism correlated negatively with treating obesity with TH (OR 0.71, CI: 0.55–0.91).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Despite the lack of evidence, and contrary to guidelines’ recommendations, about 5% of respondents stated that TH may be indicated as a treatment for obesity in euthyroid patients resistant to life-style interventions. This opinion was associated with (i) respondent characteristics: being non-endocrinologist, working in private practice, treating a small number of hypothyroid patients annually and (ii) national characteristics: prevalence of obesity, Eastern Europe, low GNI and lack of national hypothyroidism guidelines.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Obesity
lokal Surveys and Questionnaires [MeSH]
lokal Female [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Levothyroxine
lokal Hypothyroidism/epidemiology [MeSH]
lokal Middle Aged [MeSH]
lokal Hypothyroidism/therapy [MeSH]
lokal Europe/epidemiology [MeSH]
lokal Hypothyroidism/drug therapy [MeSH]
lokal Obesity/therapy [MeSH]
lokal Original Article
lokal Male [MeSH]
lokal Obesity/epidemiology [MeSH]
lokal Practice Patterns, Physicians'/standards [MeSH]
lokal Practice Patterns, Physicians'/statistics
lokal Thyroid Hormones/blood [MeSH]
lokal Hypothyroidism
lokal Survey
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0227-3566|https://orcid.org/0000-0002-2017-0694|https://orcid.org/0000-0002-1417-287X|https://orcid.org/0000-0002-9286-6471|https://orcid.org/0000-0001-9282-4530|https://orcid.org/0000-0003-4790-2733|https://orcid.org/0000-0001-7320-5574|https://orcid.org/0000-0001-9977-5970|https://orcid.org/0000-0003-2786-6616|https://orcid.org/0000-0003-3726-5793|https://orcid.org/0000-0002-1213-6832|https://orcid.org/0000-0002-5752-8709|https://orcid.org/0000-0002-1687-9297|https://orcid.org/0000-0003-0439-9867|https://orcid.org/0000-0002-0789-5156|https://orcid.org/0000-0003-0553-408X|https://orcid.org/0000-0002-5695-2831|https://orcid.org/0000-0003-1389-4157|https://orcid.org/0000-0002-8437-3933|https://orcid.org/0000-0001-7574-9292|https://orcid.org/0000-0002-3026-6315|https://orcid.org/0000-0002-1883-1588|https://orcid.org/0000-0001-8048-9050|https://orcid.org/0000-0003-0357-4192|https://orcid.org/0000-0002-9373-4462|https://orcid.org/0000-0003-0920-4854|https://orcid.org/0000-0001-5980-0529|https://orcid.org/0000-0002-9265-7274|https://orcid.org/0000-0002-8985-3151|https://orcid.org/0000-0002-1294-1217|https://orcid.org/0000-0003-3445-9090|https://orcid.org/0000-0002-3163-1097|https://orcid.org/0000-0003-4131-6813|https://orcid.org/0000-0002-3515-3264|https://orcid.org/0000-0002-9510-419X|https://orcid.org/0000-0003-4222-622X|https://orcid.org/0000-0001-8197-7603|https://orcid.org/0000-0002-7318-7166|https://orcid.org/0000-0003-1500-1586|https://orcid.org/0000-0002-6439-3523|https://orcid.org/0000-0001-9998-4895|https://orcid.org/0000-0003-1398-5067|https://orcid.org/0000-0002-5795-3318|https://orcid.org/0000-0002-6268-4212|https://orcid.org/0009-0004-3793-8163|https://orcid.org/0000-0002-6296-7220|https://orcid.org/0000-0003-2679-7153|https://orcid.org/0000-0002-8213-2968|https://orcid.org/0000-0001-7421-0981|https://orcid.org/0000-0002-8488-1735|https://orcid.org/0009-0009-2554-0971|https://orcid.org/0000-0002-5248-863X|https://orcid.org/0000-0002-0544-5952|https://orcid.org/0000-0003-0929-1003|https://orcid.org/0000-0002-9691-7619
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    1000 Förderer Universidad de Navarra |
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