Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts

  1. Ruiz-Orera, Jorge ORCID logo
  2. Miller, Duncan C.
  3. Greiner, Johannes
  4. Genehr, Carolin
  5. Grammatikaki, Aliki
  6. Blachut, Susanne
  7. Mbebi, Jeanne
  8. Patone, Giannino ORCID logo
  9. Myronova, Anna
  10. Adami, Eleonora
  11. Dewani, Nikita ORCID logo
  12. Liang, Ning
  13. Hummel, Oliver
  14. Muecke, Michael B.
  15. Hildebrandt, Thomas B.
  16. Fritsch, Guido
  17. Schrade, Lisa ORCID logo
  18. Zimmermann, Wolfram-Hubertus ORCID logo
  19. Kondova, Ivanela
  20. Diecke, Sebastian
  21. van Heesch, Sebastiaan ORCID logo
  22. Hübner, Norbert ORCID logo

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1000 Titel
  • Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts
1000 Autor/in
  1. Ruiz-Orera, Jorge |
  2. Miller, Duncan C. |
  3. Greiner, Johannes |
  4. Genehr, Carolin |
  5. Grammatikaki, Aliki |
  6. Blachut, Susanne |
  7. Mbebi, Jeanne |
  8. Patone, Giannino |
  9. Myronova, Anna |
  10. Adami, Eleonora |
  11. Dewani, Nikita |
  12. Liang, Ning |
  13. Hummel, Oliver |
  14. Muecke, Michael B. |
  15. Hildebrandt, Thomas B. |
  16. Fritsch, Guido |
  17. Schrade, Lisa |
  18. Zimmermann, Wolfram-Hubertus |
  19. Kondova, Ivanela |
  20. Diecke, Sebastian |
  21. van Heesch, Sebastiaan |
  22. Hübner, Norbert |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-09-24
1000 Erschienen in
1000 Quellenangabe
  • 3(10):1217-1235
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s44161-024-00544-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473369/ |
1000 Ergänzendes Material
  • https://static-content.springer.com/esm/art%3A10.1038%2Fs44161-024-00544-7/MediaObjects/44161_2024_544_MOESM1_ESM.pdf |
  • https://static-content.springer.com/esm/art%3A10.1038%2Fs44161-024-00544-7/MediaObjects/44161_2024_544_MOESM2_ESM.pdf |
  • https://static-content.springer.com/esm/art%3A10.1038%2Fs44161-024-00544-7/MediaObjects/44161_2024_544_MOESM3_ESM.xlsx |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Evolutionary innovations can be driven by changes in the rates of RNA translation and the emergence of new genes and small open reading frames (sORFs). In this study, we characterized the transcriptional and translational landscape of the hearts of four primate and two rodent species through integrative ribosome and transcriptomic profiling, including adult left ventricle tissues and induced pluripotent stem cell-derived cardiomyocyte cell cultures. We show here that the translational efficiencies of subunits of the mitochondrial oxidative phosphorylation chain complexes IV and V evolved rapidly across mammalian evolution. Moreover, we discovered hundreds of species-specific and lineage-specific genomic innovations that emerged during primate evolution in the heart, including 551 genes, 504 sORFs and 76 evolutionarily conserved genes displaying human-specific cardiac-enriched expression. Overall, our work describes the evolutionary processes and mechanisms that have shaped cardiac transcription and translation in recent primate evolution and sheds light on how these can contribute to cardiac development and disease.
1000 Sacherschließung
lokal Humans [MeSH]
lokal Ribosomes/genetics [MeSH]
lokal Primates/genetics [MeSH]
lokal Evolution, Molecular [MeSH]
lokal Protein Biosynthesis/genetics [MeSH]
lokal Animals [MeSH]
lokal Induced Pluripotent Stem Cells/metabolism [MeSH]
lokal Myocytes, Cardiac/metabolism [MeSH]
lokal Ribosomes/metabolism [MeSH]
lokal Gene Expression Profiling/methods [MeSH]
lokal Transcriptome [MeSH]
lokal Cells, Cultured [MeSH]
lokal Species Specificity [MeSH]
lokal Open Reading Frames/genetics [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-8317-0034|https://frl.publisso.de/adhoc/uri/TWlsbGVyLCBEdW5jYW4gQy4=|https://frl.publisso.de/adhoc/uri/R3JlaW5lciwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/R2VuZWhyLCBDYXJvbGlu|https://frl.publisso.de/adhoc/uri/R3JhbW1hdGlrYWtpLCBBbGlraQ==|https://frl.publisso.de/adhoc/uri/QmxhY2h1dCwgU3VzYW5uZQ==|https://frl.publisso.de/adhoc/uri/TWJlYmksIEplYW5uZQ==|https://orcid.org/0000-0002-7242-0341|https://frl.publisso.de/adhoc/uri/TXlyb25vdmEsIEFubmE=|https://frl.publisso.de/adhoc/uri/QWRhbWksIEVsZW9ub3Jh|https://orcid.org/0000-0002-2287-6674|https://frl.publisso.de/adhoc/uri/TGlhbmcsIE5pbmc=|https://frl.publisso.de/adhoc/uri/SHVtbWVsLCBPbGl2ZXI=|https://frl.publisso.de/adhoc/uri/TXVlY2tlLCBNaWNoYWVsIEIu|https://frl.publisso.de/adhoc/uri/SGlsZGVicmFuZHQsIFRob21hcyBCLg==|https://frl.publisso.de/adhoc/uri/RnJpdHNjaCwgR3VpZG8=|https://orcid.org/0009-0005-7249-1640|https://orcid.org/0000-0003-1190-4040|https://frl.publisso.de/adhoc/uri/S29uZG92YSwgSXZhbmVsYQ==|https://frl.publisso.de/adhoc/uri/RGllY2tlLCBTZWJhc3RpYW4=|https://orcid.org/0000-0001-9593-1980|https://orcid.org/0000-0002-1218-6223
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  1. Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft |
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    1000 Förderer Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft |
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1000 Erstellt am 2025-06-12T07:44:32.343+0200
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