Download
naturally-acquired-immunity-to-plasmodium-pitheci-in-bornean-orangutans-pongo-pygmaeus.pdf 367,34KB
WeightNameValue
1000 Titel
  • Naturally acquired immunity to <i>Plasmodium pitheci</i> in Bornean orangutans (<i>Pongo pygmaeus</i>)
1000 Autor/in
  1. Llano Sanchez, Karmele |
  2. Baird, John Kevin |
  3. Nielsen, Aileen |
  4. Nurillah, Andini |
  5. Agustina, Fitria |
  6. Komara |
  7. Fadilah, Fina |
  8. Prameswari, Wendi |
  9. Nugraha, Raden Taufiq Purna |
  10. Saputra, Sugiyono |
  11. Nurkanto, Arif |
  12. Dharmayanthi, Anik Budhi |
  13. Pratama, Rahadian |
  14. Exploitasia, Indra |
  15. Greenwood, Alex D. |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-02-16
1000 Erschienen in
1000 Quellenangabe
  • 151(4):380-389
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1017/s0031182024000155 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11044065/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Naturally acquired immunity to the different types of malaria in humans occurs in areas of endemic transmission and results in asymptomatic infection of peripheral blood. The current study examined the possibility of naturally acquired immunity in Bornean orangutans, <jats:italic>Pongo pygmaeus</jats:italic>, exposed to endemic <jats:italic>Plasmodium pitheci</jats:italic> malaria. A total of 2140 peripheral blood samples were collected between January 2017 and December 2022 from a cohort of 135 orangutans housed at a natural forested Rescue and Rehabilitation Centre in West Kalimantan, Indonesia. Each individual was observed for an average of 4.3 years during the study period. Blood samples were examined by microscopy and polymerase chain reaction for the presence of plasmodial parasites. Infection rates and parasitaemia levels were measured among age groups and all 20 documented clinical malaria cases were reviewed to estimate the incidence of illness and risk ratios among age groups. A case group of all 17 individuals that had experienced clinical malaria and a control group of 34 individuals having an event of &gt;2000 parasites μL<jats:sup>−1</jats:sup> blood but with no outward or clinical sign of illness were studied. Immature orangutans had higher-grade and more frequent parasitaemia events, but mature individuals were more likely to suffer from clinical malaria than juveniles. The case orangutans having patent clinical malaria were 256 times more likely to have had no parasitaemia event in the prior year relative to asymptomatic control orangutans. The findings are consistent with rapidly acquired immunity to <jats:italic>P. pitheci</jats:italic> illness among orangutans that wanes without re-exposure to the pathogen.</jats:p>
1000 Sacherschließung
lokal Female [MeSH]
lokal Malaria/epidemiology [MeSH]
lokal Parasitemia/epidemiology [MeSH]
lokal Parasitemia/veterinary [MeSH]
lokal Malaria/parasitology [MeSH]
lokal Incidence [MeSH]
lokal Animals [MeSH]
lokal Malaria/immunology [MeSH]
lokal Ape Diseases/parasitology [MeSH]
lokal Male [MeSH]
lokal Parasitemia/parasitology [MeSH]
lokal Plasmodium/immunology [MeSH]
lokal Pongo pygmaeus/parasitology [MeSH]
lokal Indonesia/epidemiology [MeSH]
lokal Ape Diseases/epidemiology [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0009-0006-8813-7344|https://frl.publisso.de/adhoc/uri/QmFpcmQsIEpvaG4gS2V2aW4=|https://frl.publisso.de/adhoc/uri/TmllbHNlbiwgQWlsZWVu|https://frl.publisso.de/adhoc/uri/TnVyaWxsYWgsIEFuZGluaQ==|https://frl.publisso.de/adhoc/uri/QWd1c3RpbmEsIEZpdHJpYQ==|https://frl.publisso.de/adhoc/uri/S29tYXJh|https://frl.publisso.de/adhoc/uri/RmFkaWxhaCwgRmluYQ==|https://frl.publisso.de/adhoc/uri/UHJhbWVzd2FyaSwgV2VuZGk=|https://frl.publisso.de/adhoc/uri/TnVncmFoYSwgUmFkZW4gVGF1ZmlxIFB1cm5h|https://frl.publisso.de/adhoc/uri/U2FwdXRyYSwgU3VnaXlvbm8=|https://frl.publisso.de/adhoc/uri/TnVya2FudG8sIEFyaWY=|https://frl.publisso.de/adhoc/uri/RGhhcm1heWFudGhpLCBBbmlrIEJ1ZGhp|https://frl.publisso.de/adhoc/uri/UHJhdGFtYSwgUmFoYWRpYW4=|https://frl.publisso.de/adhoc/uri/RXhwbG9pdGFzaWEsIEluZHJh|https://frl.publisso.de/adhoc/uri/R3JlZW53b29kLCBBbGV4IEQu
1000 Hinweis
  • metadata provieded by: LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Naturally acquired immunity to <i>Plasmodium pitheci</i> in Bornean orangutans (<i>Pongo pygmaeus</i>)
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6511788.rdf
1000 Erstellt am 2025-06-12T07:45:02.137+0200
1000 Erstellt von 336
1000 beschreibt frl:6511788
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2025-07-01T09:54:53.267+0200
1000 Objekt bearb. Tue Jul 01 09:54:44 CEST 2025
1000 Vgl. frl:6511788
1000 Oai Id
  1. oai:frl.publisso.de:frl:6511788 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source