Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

  1. Welsh, Joshua ORCID logo
  2. Goberdhan, Deborah ORCID logo
  3. O'Driscoll, Lorraine
  4. Buzás, Edit ORCID logo
  5. Blenkiron, Cherie
  6. Bussolati, Benedetta ORCID logo
  7. Whitley, Joseph ORCID logo
  8. Di Vizio, Dolores
  9. Driedonks, Tom A. P.
  10. Erdbrügger, Uta
  11. Falcon-Perez, Juan M ORCID logo
  12. Fu, Qing‐Ling
  13. Hill, Andrew ORCID logo
  14. Lenassi, Metka ORCID logo
  15. Lim, Sai Kiang
  16. Mahoney, Mỹ G.
  17. Mohanty, Sujata ORCID logo
  18. Möller, Andreas
  19. Nieuwland, Rienk ORCID logo
  20. Ochiya, Takahiro ORCID logo
  21. Sahoo, Susmita ORCID logo
  22. Torrecilhas, Ana Claudia ORCID logo
  23. Zheng, Lei ORCID logo
  24. Zijlstra, Andries ORCID logo
  25. Abuelreich, Sarah
  26. Bagabas, Reem
  27. Bergese, Paolo
  28. Bridges, Esther M.
  29. BRUCALE, MARCO ORCID logo
  30. Burger, Dylan
  31. Carney, Randy ORCID logo
  32. Cocucci, Emanuele
  33. Crescitelli, Rossella ORCID logo
  34. Hanser, Edveena
  35. Harris, Adrian L.
  36. Haughey, Norman ORCID logo
  37. Hendrix, An
  38. Ivanov, Alexander R.
  39. Jovanovic‐Talisman, Tijana
  40. Kruh‐Garcia, Nicole A.
  41. Ku'ulei‐Lyn Faustino, Vroniqa
  42. Kyburz, Diego
  43. Lässer, Cecilia
  44. Lennon, Kathleen M.
  45. Lötvall, Jan
  46. Maddox, Adam L.
  47. Martens-Uzunova, Elena ORCID logo
  48. Mizenko, Rachel R.
  49. Newman, Lauren ORCID logo
  50. Ridolfi, Andrea
  51. Rohde, Eva ORCID logo
  52. Rojalin, Tatu
  53. Rowland, Andrew
  54. Saftics, Andras
  55. Sandau, Ursula ORCID logo
  56. Saugstad, Julie ORCID logo
  57. Shekari, Faezeh ORCID logo
  58. Swift, Simon
  59. Ter‐Ovanesyan, Dmitry
  60. Tosar, Juan ORCID logo
  61. Useckaite, Zivile
  62. Valle, Francesco
  63. Varga, Zoltan
  64. van der Pol, Edwin
  65. van Herwijnen, Martijn J. C.
  66. Wauben, Marca ORCID logo
  67. Wehman, Ann M ORCID logo
  68. Williams, Sarah
  69. Zendrini, Andrea
  70. Zimmerman, Alan J. ORCID logo
  71. MISEV Consortium
  72. théry, clotilde ORCID logo
  73. Witwer, Kenneth ORCID logo

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J of Extracellular Vesicle - 2024 - Welsh - Minimal information for studies of extracellular vesicles MISEV2023 From.pdf 2,46MB
WeightNameValue
1000 Titel
  • Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
1000 Autor/in
  1. Welsh, Joshua |
  2. Goberdhan, Deborah |
  3. O'Driscoll, Lorraine |
  4. Buzás, Edit |
  5. Blenkiron, Cherie |
  6. Bussolati, Benedetta |
  7. Whitley, Joseph |
  8. Di Vizio, Dolores |
  9. Driedonks, Tom A. P. |
  10. Erdbrügger, Uta |
  11. Falcon-Perez, Juan M |
  12. Fu, Qing‐Ling |
  13. Hill, Andrew |
  14. Lenassi, Metka |
  15. Lim, Sai Kiang |
  16. Mahoney, Mỹ G. |
  17. Mohanty, Sujata |
  18. Möller, Andreas |
  19. Nieuwland, Rienk |
  20. Ochiya, Takahiro |
  21. Sahoo, Susmita |
  22. Torrecilhas, Ana Claudia |
  23. Zheng, Lei |
  24. Zijlstra, Andries |
  25. Abuelreich, Sarah |
  26. Bagabas, Reem |
  27. Bergese, Paolo |
  28. Bridges, Esther M. |
  29. BRUCALE, MARCO |
  30. Burger, Dylan |
  31. Carney, Randy |
  32. Cocucci, Emanuele |
  33. Crescitelli, Rossella |
  34. Hanser, Edveena |
  35. Harris, Adrian L. |
  36. Haughey, Norman |
  37. Hendrix, An |
  38. Ivanov, Alexander R. |
  39. Jovanovic‐Talisman, Tijana |
  40. Kruh‐Garcia, Nicole A. |
  41. Ku'ulei‐Lyn Faustino, Vroniqa |
  42. Kyburz, Diego |
  43. Lässer, Cecilia |
  44. Lennon, Kathleen M. |
  45. Lötvall, Jan |
  46. Maddox, Adam L. |
  47. Martens-Uzunova, Elena |
  48. Mizenko, Rachel R. |
  49. Newman, Lauren |
  50. Ridolfi, Andrea |
  51. Rohde, Eva |
  52. Rojalin, Tatu |
  53. Rowland, Andrew |
  54. Saftics, Andras |
  55. Sandau, Ursula |
  56. Saugstad, Julie |
  57. Shekari, Faezeh |
  58. Swift, Simon |
  59. Ter‐Ovanesyan, Dmitry |
  60. Tosar, Juan |
  61. Useckaite, Zivile |
  62. Valle, Francesco |
  63. Varga, Zoltan |
  64. van der Pol, Edwin |
  65. van Herwijnen, Martijn J. C. |
  66. Wauben, Marca |
  67. Wehman, Ann M |
  68. Williams, Sarah |
  69. Zendrini, Andrea |
  70. Zimmerman, Alan J. |
  71. MISEV Consortium |
  72. théry, clotilde |
  73. Witwer, Kenneth |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-02-07
1000 Erschienen in
1000 Quellenangabe
  • 13(2):e12404
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/jev2.12404 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850029/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.
1000 Sacherschließung
lokal Extracellular Vesicles/metabolism [MeSH]
lokal Biomarkers/metabolism [MeSH]
lokal Phenotype [MeSH]
lokal Exosomes/metabolism [MeSH]
lokal Biological Transport [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1097-9756|https://orcid.org/0000-0003-0645-6714|https://frl.publisso.de/adhoc/uri/TydEcmlzY29sbCwgTG9ycmFpbmU=|https://orcid.org/0000-0002-3744-206X|https://frl.publisso.de/adhoc/uri/Qmxlbmtpcm9uLCBDaGVyaWU=|https://orcid.org/0000-0002-3663-5134|https://orcid.org/0000-0003-4887-2652|https://frl.publisso.de/adhoc/uri/RGkgVml6aW8sIERvbG9yZXM=|https://frl.publisso.de/adhoc/uri/RHJpZWRvbmtzLCBUb20gQS4gUC4=|https://frl.publisso.de/adhoc/uri/RXJkYnLDvGdnZXIsIFV0YQ==|https://orcid.org/0000-0003-3133-0670|https://frl.publisso.de/adhoc/uri/RnUsIFFpbmfigJBMaW5n|https://orcid.org/0000-0001-5581-2354|https://orcid.org/0000-0002-9488-6855|https://frl.publisso.de/adhoc/uri/TGltLCBTYWkgS2lhbmc=|https://frl.publisso.de/adhoc/uri/TWFob25leSwgTeG7uSBHLg==|https://orcid.org/0000-0002-0047-4914|https://frl.publisso.de/adhoc/uri/TcO2bGxlciwgQW5kcmVhcw==|https://orcid.org/0000-0002-5671-3400|https://orcid.org/0000-0002-0776-9918|https://orcid.org/0000-0002-7279-1564|https://orcid.org/0000-0001-5724-2199|https://orcid.org/0000-0003-2576-8780|https://orcid.org/0000-0001-8460-8803|https://frl.publisso.de/adhoc/uri/QWJ1ZWxyZWljaCwgU2FyYWg=|https://frl.publisso.de/adhoc/uri/QmFnYWJhcywgUmVlbQ==|https://frl.publisso.de/adhoc/uri/QmVyZ2VzZSwgUGFvbG8=|https://frl.publisso.de/adhoc/uri/QnJpZGdlcywgRXN0aGVyIE0u|https://orcid.org/0000-0001-7244-4389|https://frl.publisso.de/adhoc/uri/QnVyZ2VyLCBEeWxhbg==|https://orcid.org/0000-0001-8193-1664|https://frl.publisso.de/adhoc/uri/Q29jdWNjaSwgRW1hbnVlbGU=|https://orcid.org/0000-0002-1714-3169|https://frl.publisso.de/adhoc/uri/SGFuc2VyLCBFZHZlZW5h|https://frl.publisso.de/adhoc/uri/SGFycmlzLCBBZHJpYW4gTC4=|https://orcid.org/0000-0001-5194-4122|https://frl.publisso.de/adhoc/uri/SGVuZHJpeCwgQW4=|https://frl.publisso.de/adhoc/uri/SXZhbm92LCBBbGV4YW5kZXIgUi4=|https://frl.publisso.de/adhoc/uri/Sm92YW5vdmlj4oCQVGFsaXNtYW4sIFRpamFuYQ==|https://frl.publisso.de/adhoc/uri/S3J1aOKAkEdhcmNpYSwgTmljb2xlIEEu|https://frl.publisso.de/adhoc/uri/S3UndWxlaeKAkEx5biBGYXVzdGlubywgVnJvbmlxYQ==|https://frl.publisso.de/adhoc/uri/S3lidXJ6LCBEaWVnbw==|https://frl.publisso.de/adhoc/uri/TMOkc3NlciwgQ2VjaWxpYQ==|https://frl.publisso.de/adhoc/uri/TGVubm9uLCBLYXRobGVlbiBNLg==|https://frl.publisso.de/adhoc/uri/TMO2dHZhbGwsIEphbg==|https://frl.publisso.de/adhoc/uri/TWFkZG94LCBBZGFtIEwu|https://orcid.org/0000-0002-5363-2525|https://frl.publisso.de/adhoc/uri/TWl6ZW5rbywgUmFjaGVsIFIu|https://orcid.org/0000-0003-3303-1666|https://frl.publisso.de/adhoc/uri/Umlkb2xmaSwgQW5kcmVh|https://orcid.org/0000-0001-8692-886X|https://frl.publisso.de/adhoc/uri/Um9qYWxpbiwgVGF0dQ==|https://frl.publisso.de/adhoc/uri/Um93bGFuZCwgQW5kcmV3|https://frl.publisso.de/adhoc/uri/U2FmdGljcywgQW5kcmFz|https://orcid.org/0000-0002-3646-7089|https://orcid.org/0000-0002-2996-9611|https://orcid.org/0000-0001-6026-5412|https://frl.publisso.de/adhoc/uri/U3dpZnQsIFNpbW9u|https://frl.publisso.de/adhoc/uri/VGVy4oCQT3ZhbmVzeWFuLCBEbWl0cnk=|https://orcid.org/0000-0002-2021-2479|https://frl.publisso.de/adhoc/uri/VXNlY2thaXRlLCBaaXZpbGU=|https://frl.publisso.de/adhoc/uri/VmFsbGUsIEZyYW5jZXNjbw==|https://frl.publisso.de/adhoc/uri/VmFyZ2EsIFpvbHRhbg==|https://frl.publisso.de/adhoc/uri/dmFuIGRlciBQb2wsIEVkd2lu|https://frl.publisso.de/adhoc/uri/dmFuIEhlcndpam5lbiwgTWFydGlqbiBKLiBDLg==|https://orcid.org/0000-0003-0360-0311|https://orcid.org/0000-0001-9826-4132|https://frl.publisso.de/adhoc/uri/V2lsbGlhbXMsIFNhcmFo|https://frl.publisso.de/adhoc/uri/WmVuZHJpbmksIEFuZHJlYQ==|https://orcid.org/0000-0001-6280-4790|https://frl.publisso.de/adhoc/uri/TUlTRVYgQ29uc29ydGl1bQ==|https://orcid.org/0000-0001-8294-6884|https://orcid.org/0000-0003-1664-4233
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  1. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
    Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
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