Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis

  1. Shi, Fanchao
  2. Chowdhury, Rajiv
  3. Sofianopoulou, Eleni
  4. Koulman, Albert ORCID logo
  5. Sun, Luanluan
  6. Steur, Marinka
  7. Aleksandrova, Krasimira ORCID logo
  8. Dahm, Christina ORCID logo
  9. Schulze, Matthias B
  10. van der Shouw, Yvonne T
  11. Agnoli, Claudia ORCID logo
  12. Amiano, Pilar
  13. Boer, Jolanda M A
  14. Bork, Christian S
  15. Cabrera-Castro, Natalia
  16. Eichelmann, Fabian
  17. Elbaz, Alexis ORCID logo
  18. Farràs, Marta
  19. Heath, Alicia ORCID logo
  20. Kaaks, Rudolf ORCID logo
  21. Katzke, Verena ORCID logo
  22. Keski-Rahkonen, Pekka
  23. Masala, Giovanna ORCID logo
  24. Moreno-Iribas, Conchi
  25. Panico, Salvatore
  26. Papier, Keren ORCID logo
  27. Petrova, Dafina
  28. Quirós, J Ramón
  29. RICCERI, FULVIO ORCID logo
  30. Severi, Gianluca
  31. Tjonneland, Anne ORCID logo
  32. Tong, Tammy Y N
  33. tumino, rosario ORCID logo
  34. Wareham, Nicholas J
  35. Weiderpass, Elisabete
  36. Di Angelantonio, Emanuele ORCID logo
  37. Forouhi, Nita ORCID logo
  38. Danesh, John
  39. Butterworth, Adam S
  40. Kaptoge, Stephen ORCID logo

Download
Shi-et-al_2024_Association of circulating fatty acids with cardiovascular disease risk.pdf 1,11MB
WeightNameValue
1000 Titel
  • Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis
1000 Autor/in
  1. Shi, Fanchao |
  2. Chowdhury, Rajiv |
  3. Sofianopoulou, Eleni |
  4. Koulman, Albert |
  5. Sun, Luanluan |
  6. Steur, Marinka |
  7. Aleksandrova, Krasimira |
  8. Dahm, Christina |
  9. Schulze, Matthias B |
  10. van der Shouw, Yvonne T |
  11. Agnoli, Claudia |
  12. Amiano, Pilar |
  13. Boer, Jolanda M A |
  14. Bork, Christian S |
  15. Cabrera-Castro, Natalia |
  16. Eichelmann, Fabian |
  17. Elbaz, Alexis |
  18. Farràs, Marta |
  19. Heath, Alicia |
  20. Kaaks, Rudolf |
  21. Katzke, Verena |
  22. Keski-Rahkonen, Pekka |
  23. Masala, Giovanna |
  24. Moreno-Iribas, Conchi |
  25. Panico, Salvatore |
  26. Papier, Keren |
  27. Petrova, Dafina |
  28. Quirós, J Ramón |
  29. RICCERI, FULVIO |
  30. Severi, Gianluca |
  31. Tjonneland, Anne |
  32. Tong, Tammy Y N |
  33. tumino, rosario |
  34. Wareham, Nicholas J |
  35. Weiderpass, Elisabete |
  36. Di Angelantonio, Emanuele |
  37. Forouhi, Nita |
  38. Danesh, John |
  39. Butterworth, Adam S |
  40. Kaptoge, Stephen |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-10-04
1000 Erschienen in
1000 Quellenangabe
  • 32(3):233-246
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1093/eurjpc/zwae315 |
  • https://pubmed.ncbi.nlm.nih.gov/39365172/ |
1000 Ergänzendes Material
  • https://academic.oup.com/eurjpc/article/32/3/233/7810960#503700291 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • AIMS: Associations of saturated and unsaturated fatty acids (FAs) with cardiovascular disease (CVD) remain controversial. We therefore aimed to investigate the prospective associations of objectively measured FAs with CVD, including incident coronary heart disease (CHD) and stroke, as well as CVD mortality. METHODS AND RESULTS: Circulating FA concentrations expressed as the percentage of total FAs were assayed in 172 891 participants without prior vascular disease at baseline from the European Prospective Investigation into Cancer and Nutrition-CVD (EPIC-CVD) (7343 CHD; 6499 stroke), UK Biobank (1825; 1474), and INTERVAL (285; 209) cohort studies. Hazard ratio (HR) per 1-standard deviation (SD) higher FA concentrations was estimated using Cox regression models and pooled by random-effects meta-analysis. Systematic reviews with meta-analysis published by 6 May 2023 on associations between FAs and CVDs were systematically searched and updated meta-analyses using random-effects model were conducted. Evidence from randomized controlled trials (RCTs) was also summarized. Higher concentrations of total saturated FAs (SFAs) were associated with higher cardiovascular risks in the combined analysis, with differential findings noted for SFA sub-types in further analysis restricted to EPIC-CVD: positive associations for even-chain SFA [HR for CHD 1.24 (95% CI: 1.18–1.32); stroke 1.23 (1.10–1.38)] and negative associations for odd-chain [0.82 (0.76–0.87); 0.73 (0.67–0.78)] and longer-chain [0.95 (0.80–1.12); 0.84 (0.72–0.99)] SFA. In the combined analysis, total n-3 polyunsaturated FA (PUFA) [0.91 (0.85–0.97)], including docosahexaenoic acid (DHA) [0.91 (0.84–0.98)], was negatively associated with incident CHD risk. Similarly, total n-6 PUFA [0.94 (0.91–0.98)], including linoleic acid (LA) [0.89 (0.83–0.95)], was negatively associated with incident stroke risk. In contrast, more detailed analyses in EPIC-CVD revealed that several downstream n-6 PUFAs of LA were positively associated with CHD risk. Updated meta-analyses of 37 FAs including 49 non-overlapping studies, involving between 7787 and 22 802 CHD cases and between 6499 and 14 221 stroke cases, showed broadly similar results as our combined empirical analysis and further suggested significant inverse associations of individual long-chain n-3 PUFAs and LA on both CHD and stroke. The findings of long-chain n-3 PUFAs were consistent with those from published RCTs on CHD despite insufficient evidence in monotherapy, while RCT evidence remained unclear for the rest of the explored FAs. CONCLUSION: Our study provides an overview of the most recent evidence on the associations between objectively measured FAs and CVD outcomes. Collectively, the data reveal notable differences in associations by SFA sub-types and call for further studies, especially RCTs, to explore these links.
1000 Sacherschließung
lokal Stroke
lokal Fatty acids
lokal Cohort study
lokal Coronary heart disease
lokal Cardiovascular disease
lokal Meta-analysis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2hpLCBGYW5jaGFv|https://frl.publisso.de/adhoc/uri/Q2hvd2RodXJ5LCBSYWppdg==|https://frl.publisso.de/adhoc/uri/U29maWFub3BvdWxvdSwgRWxlbmk=|https://orcid.org/0000-0001-9998-051X|https://frl.publisso.de/adhoc/uri/U3VuLCBMdWFubHVhbg==|https://frl.publisso.de/adhoc/uri/U3RldXIsIE1hcmlua2E=|https://orcid.org/0000-0002-1275-1827|https://orcid.org/0000-0003-0481-2893|https://frl.publisso.de/adhoc/uri/U2NodWx6ZSwgTWF0dGhpYXMgQg==|https://frl.publisso.de/adhoc/uri/dmFuIGRlciBTaG91dywgWXZvbm5lIFQ=|https://orcid.org/0000-0003-4472-1179|https://frl.publisso.de/adhoc/uri/QW1pYW5vLCBQaWxhcg==|https://frl.publisso.de/adhoc/uri/Qm9lciwgSm9sYW5kYSBNIEE=|https://frl.publisso.de/adhoc/uri/Qm9yaywgQ2hyaXN0aWFuIFM=|https://frl.publisso.de/adhoc/uri/Q2FicmVyYS1DYXN0cm8sIE5hdGFsaWE=|https://frl.publisso.de/adhoc/uri/RWljaGVsbWFubiwgRmFiaWFu|https://orcid.org/0000-0001-9724-5490|https://frl.publisso.de/adhoc/uri/RmFycsOgcywgTWFydGE=|https://orcid.org/0000-0001-6517-1300|https://orcid.org/0000-0003-3751-3929|https://orcid.org/0000-0002-6509-6555|https://frl.publisso.de/adhoc/uri/S2Vza2ktUmFoa29uZW4sIFBla2th|https://orcid.org/0000-0002-5758-9069|https://frl.publisso.de/adhoc/uri/TW9yZW5vLUlyaWJhcywgQ29uY2hp|https://frl.publisso.de/adhoc/uri/UGFuaWNvLCBTYWx2YXRvcmU=|https://orcid.org/0000-0002-4102-6835|https://frl.publisso.de/adhoc/uri/UGV0cm92YSwgRGFmaW5h|https://frl.publisso.de/adhoc/uri/UXVpcsOzcywgSiBSYW3Ds24=|https://orcid.org/0000-0001-8749-9737|https://frl.publisso.de/adhoc/uri/U2V2ZXJpLCBHaWFubHVjYQ==|https://orcid.org/0000-0003-4385-2097|https://frl.publisso.de/adhoc/uri/VG9uZywgVGFtbXkgWSBO|https://orcid.org/0000-0003-2666-414X|https://frl.publisso.de/adhoc/uri/V2FyZWhhbSwgTmljaG9sYXMgSg==|https://frl.publisso.de/adhoc/uri/V2VpZGVycGFzcywgRWxpc2FiZXRl|https://orcid.org/0000-0001-8776-6719|https://orcid.org/0000-0002-5041-248X|https://frl.publisso.de/adhoc/uri/RGFuZXNoLCBKb2hu|https://frl.publisso.de/adhoc/uri/QnV0dGVyd29ydGgsIEFkYW0gUw==|https://orcid.org/0000-0002-1155-4872
1000 Label
1000 Förderer
  1. Seventh Framework Programme |
  2. European Research Council |
  3. Medical Research Council |
  4. British Heart Foundation |
  5. NIHR Cambridge Biomedical Research Centre |
  6. Sixth Framework Programme |
  7. Medical Research Council Epidemiology Unit |
  8. Centre International de Recherche sur le Cancer |
1000 Fördernummer
  1. HEALTH-F2-2012-279233
  2. 268834
  3. G0800270; MR/L003120/1
  4. P/09/002; RG/ 13/13/30194; RG/18/13/3394
  5. NIHR203312
  6. LSHM_CT_2006_037197
  7. MC_UU_00006/1
  8. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer HEALTH-F2-2012-279233
  2. 1000 joinedFunding-child
    1000 Förderer European Research Council |
    1000 Förderprogramm -
    1000 Fördernummer 268834
  3. 1000 joinedFunding-child
    1000 Förderer Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer G0800270; MR/L003120/1
  4. 1000 joinedFunding-child
    1000 Förderer British Heart Foundation |
    1000 Förderprogramm -
    1000 Fördernummer P/09/002; RG/ 13/13/30194; RG/18/13/3394
  5. 1000 joinedFunding-child
    1000 Förderer NIHR Cambridge Biomedical Research Centre |
    1000 Förderprogramm -
    1000 Fördernummer NIHR203312
  6. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer LSHM_CT_2006_037197
  7. 1000 joinedFunding-child
    1000 Förderer Medical Research Council Epidemiology Unit |
    1000 Förderprogramm -
    1000 Fördernummer MC_UU_00006/1
  8. 1000 joinedFunding-child
    1000 Förderer Centre International de Recherche sur le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6511899.rdf
1000 Erstellt am 2025-06-25T15:07:37.652+0200
1000 Erstellt von 266
1000 beschreibt frl:6511899
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2025-09-12T14:46:42.552+0200
1000 Objekt bearb. Mon Jun 30 09:34:19 CEST 2025
1000 Vgl. frl:6511899
1000 Oai Id
  1. oai:frl.publisso.de:frl:6511899 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source