Bidirectional relationship between olfaction and Parkinson’s disease

  1. Kim, Jonggeol Jeffrey
  2. Bandres-Ciga, Sara
  3. Heilbron, Karl
  4. 23andMe Research Team
  5. Aslibekyan, Stella
  6. Auton, Adam
  7. Babalola, Elizabeth
  8. Bell, Robert K.
  9. Bielenberg, Jessica
  10. Bowes, Jonathan
  11. Bryc, Katarzyna
  12. Chaudhary, Ninad S.
  13. Coker, Daniella
  14. Das, Sayantan
  15. DelloRusso, Emily
  16. Elson, Sarah L.
  17. Eriksson, Nicholas
  18. Filshtein, Teresa
  19. Fontanillas, Pierre
  20. Freyman, Will
  21. Fuller, Zach
  22. German, Chris
  23. Granka, Julie M.
  24. Hernandez, Alejandro
  25. Hicks, Barry
  26. Hinds, David A.
  27. Jewett, Ethan M.
  28. Jiang, Yunxuan
  29. Kukar, Katelyn
  30. Kwong, Alan
  31. Liang, Yanyu
  32. Lin, Keng-Han
  33. Llamas, Bianca A.
  34. McIntyre, Matthew H.
  35. Micheletti, Steven J.
  36. Moreno, Meghan E.
  37. Nandakumar, Priyanka
  38. Nguyen, Dominique T.
  39. O’Connell, Jared
  40. Petrakovitz, Aaron A.
  41. Poznik, G. David
  42. Reynoso, Alexandra
  43. Saini, Shubham
  44. Schumacher, Morgan
  45. Selcer, Leah
  46. Shastri, Anjali J.
  47. Shelton, Janie F.
  48. Shi, Jingchunzi
  49. Shringarpure, Suyash
  50. Su, Qiaojuan Jane
  51. Tat, Susana A.
  52. Tran, Vinh
  53. Tung, Joyce Y.
  54. Wang, Xin
  55. Wang, Wei
  56. Weldon, Catherine H.
  57. Wilton, Peter
  58. Wong, Corinna D.
  59. Blauwendraat, Cornelis
  60. Noyce, Alastair ORCID logo

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WeightNameValue
1000 Titel
  • Bidirectional relationship between olfaction and Parkinson’s disease
1000 Autor/in
  1. Kim, Jonggeol Jeffrey |
  2. Bandres-Ciga, Sara |
  3. Heilbron, Karl |
  4. 23andMe Research Team |
  5. Aslibekyan, Stella |
  6. Auton, Adam |
  7. Babalola, Elizabeth |
  8. Bell, Robert K. |
  9. Bielenberg, Jessica |
  10. Bowes, Jonathan |
  11. Bryc, Katarzyna |
  12. Chaudhary, Ninad S. |
  13. Coker, Daniella |
  14. Das, Sayantan |
  15. DelloRusso, Emily |
  16. Elson, Sarah L. |
  17. Eriksson, Nicholas |
  18. Filshtein, Teresa |
  19. Fontanillas, Pierre |
  20. Freyman, Will |
  21. Fuller, Zach |
  22. German, Chris |
  23. Granka, Julie M. |
  24. Hernandez, Alejandro |
  25. Hicks, Barry |
  26. Hinds, David A. |
  27. Jewett, Ethan M. |
  28. Jiang, Yunxuan |
  29. Kukar, Katelyn |
  30. Kwong, Alan |
  31. Liang, Yanyu |
  32. Lin, Keng-Han |
  33. Llamas, Bianca A. |
  34. McIntyre, Matthew H. |
  35. Micheletti, Steven J. |
  36. Moreno, Meghan E. |
  37. Nandakumar, Priyanka |
  38. Nguyen, Dominique T. |
  39. O’Connell, Jared |
  40. Petrakovitz, Aaron A. |
  41. Poznik, G. David |
  42. Reynoso, Alexandra |
  43. Saini, Shubham |
  44. Schumacher, Morgan |
  45. Selcer, Leah |
  46. Shastri, Anjali J. |
  47. Shelton, Janie F. |
  48. Shi, Jingchunzi |
  49. Shringarpure, Suyash |
  50. Su, Qiaojuan Jane |
  51. Tat, Susana A. |
  52. Tran, Vinh |
  53. Tung, Joyce Y. |
  54. Wang, Xin |
  55. Wang, Wei |
  56. Weldon, Catherine H. |
  57. Wilton, Peter |
  58. Wong, Corinna D. |
  59. Blauwendraat, Cornelis |
  60. Noyce, Alastair |
1000 Verlag Nature Publishing Group UK
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-12-05
1000 Erschienen in
1000 Quellenangabe
  • 10(1):232
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41531-024-00838-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621548/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Hyposmia (decreased smell function) is a common early symptom of Parkinson’s disease (PD). The shared genetic architecture between hyposmia and PD is unknown. We leveraged genome-wide association study (GWAS) results for self-assessment of ‘ability to smell’ and PD diagnosis to determine shared genetic architecture between the two traits. Linkage disequilibrium score (LDSC) regression found that the sense of smell negatively correlated at a genome-wide level with PD. Local Analysis of [co]Variant Association (LAVA) found negative correlations in four genetic loci near <jats:italic>GBA1</jats:italic>, <jats:italic>ANAPC4</jats:italic>, <jats:italic>SNCA</jats:italic>, and <jats:italic>MAPT</jats:italic>, indicating shared genetic liability only within a subset of prominent PD risk genes. Using Mendelian randomization, we found evidence for a strong causal relationship between PD and liability towards poorer sense of smell, but weaker evidence for the reverse direction. This work highlights the heritability of olfactory function and its relationship with PD heritability and provides further insight into the association between PD and hyposmia.</jats:p>
1000 Sacherschließung
lokal Article
lokal /692/499
lokal /692/699/375/1718
lokal /692/1807
lokal article
lokal /631/208/212
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1000 Hinweis
  • DeepGreen-ID: 61a784219bc1409da0e6fff3c04a8cca ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. Parkinson's UK |
  2. Cure Parkinson's Trust |
  3. Michael J. Fox Foundation for Parkinson's Research |
  4. Innovate UK |
  5. NIHR, Alchemab, Virginia Keiley benefaction, Aligning Science Across Parkinson's Global Parkinson’s Genetics Program |
  6. National Institute on Aging |
  7. National Institute of Neurological Disorders and Stroke |
1000 Fördernummer
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1000 Förderprogramm
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1000 Dateien
  1. Bidirectional relationship between olfaction and Parkinson’s disease
    Bidirectional relationship between olfaction and Parkinson’s disease
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Parkinson's UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Cure Parkinson's Trust |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Michael J. Fox Foundation for Parkinson's Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Innovate UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer NIHR, Alchemab, Virginia Keiley benefaction, Aligning Science Across Parkinson's Global Parkinson’s Genetics Program |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer National Institute on Aging |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer National Institute of Neurological Disorders and Stroke |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6517322.rdf
1000 Erstellt am 2025-07-05T03:36:33.041+0200
1000 Erstellt von 322
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1000 Zuletzt bearbeitet 2025-09-09T16:29:18.881+0200
1000 Objekt bearb. Tue Sep 09 16:29:18 CEST 2025
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