Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients

  1. Yeboah, Augustine
  2. Vivekanandan, Monikamira
  3. Adankwah, Ernest
  4. Owusu, Dorcas O.
  5. Aniagyei, Wilfred
  6. Minadzi, Difery
  7. Acheampong, Isaac
  8. Arthur, Joseph F.
  9. Lamptey, Millicent
  10. Abass, Mohammed K.
  11. Kumbel, Francis
  12. Osei-Yeboah, Francis
  13. Gawusu, Amidu
  14. Debrah, Linda Batsa
  15. Debrah, Alexander
  16. Mayatepek, Ertan
  17. Seyfarth, Julia
  18. Phillips, Richard O.
  19. Jacobsen, Marc

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WeightNameValue
1000 Titel
  • Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients
1000 Autor/in
  1. Yeboah, Augustine |
  2. Vivekanandan, Monikamira |
  3. Adankwah, Ernest |
  4. Owusu, Dorcas O. |
  5. Aniagyei, Wilfred |
  6. Minadzi, Difery |
  7. Acheampong, Isaac |
  8. Arthur, Joseph F. |
  9. Lamptey, Millicent |
  10. Abass, Mohammed K. |
  11. Kumbel, Francis |
  12. Osei-Yeboah, Francis |
  13. Gawusu, Amidu |
  14. Debrah, Linda Batsa |
  15. Debrah, Alexander |
  16. Mayatepek, Ertan |
  17. Seyfarth, Julia |
  18. Phillips, Richard O. |
  19. Jacobsen, Marc |
1000 Verlag BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-11-07
1000 Erschienen in
1000 Quellenangabe
  • 23(1):97
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12941-024-00756-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545981/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Immunopathology of human tuberculosis (TB) in a subgroup of patients is characterized by aberrantly high concentrations of inflammatory cytokines, for example Interleukin (IL)-6. Concomitant (co-)infections by parasites can affect host immunity, but the impact on immunopathology in TB patients is poorly defined. Here we characterized a group of patients with TB ( n = 76) from Ghana with different protozoan and helminth co-infections. Plasma cytokines were measured at the onset of disease and anti-mycobacterial treatment efficacy was monitored during disease course. A subgroup of TB patients had co-infections with protozoan (n = 19) or helminth (n = 16) parasites. Plasma analyses for candidate cytokines identified lower levels of IL-6 in parasite co-infected patients with TB. Moreover, it took less time for co-infected patients to become sputum-negative for <jats:italic>Mycobacterium tuberculosis</jats:italic> during treatment. These results indicated an influence of parasite co-infections on immunopathology in TB and suggested positive effects on treatment efficacy.</jats:p>
1000 Sacherschließung
lokal Treatment efficacy
lokal Brief Report
lokal Male [MeSH]
lokal Tuberculosis, Pulmonary/immunology [MeSH]
lokal Co-infections
lokal Sputum/microbiology [MeSH]
lokal Coinfection/microbiology [MeSH]
lokal IL-6
lokal Female [MeSH]
lokal Ghana [MeSH]
lokal Adult [MeSH]
lokal Helminthiasis/complications [MeSH]
lokal Humans [MeSH]
lokal Tuberculosis, Pulmonary/complications [MeSH]
lokal Mycobacterium tuberculosis/immunology [MeSH]
lokal Antitubercular Agents/therapeutic use [MeSH]
lokal Middle Aged [MeSH]
lokal Coinfection/parasitology [MeSH]
lokal Protozoan Infections/complications [MeSH]
lokal Animals [MeSH]
lokal Cytokines/blood [MeSH]
lokal Sputum/parasitology [MeSH]
lokal Tuberculosis
lokal Young Adult [MeSH]
lokal Interleukin-6/blood [MeSH]
lokal Helminthiasis/immunology [MeSH]
lokal Coinfection/immunology [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Deutsche Forschungsgemeinschaft |
  2. Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts |
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  2. -
1000 Förderprogramm
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  2. -
1000 Dateien
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  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6517554.rdf
1000 Erstellt am 2025-07-05T05:10:22.131+0200
1000 Erstellt von 322
1000 beschreibt frl:6517554
1000 Zuletzt bearbeitet 2025-08-19T12:11:32.103+0200
1000 Objekt bearb. Tue Aug 19 12:11:32 CEST 2025
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