Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study

  1. Forchhammer, Stephan ORCID logo
  2. Pop, Oltin-Tiberiu ORCID logo
  3. Hahn, Matthias
  4. Aebischer, Valentin ORCID logo
  5. Seitz, Christian M.
  6. Schroeder, Christopher
  7. Liebmann, Alexandra
  8. Abele, Michael ORCID logo
  9. Wild, Hannah
  10. Bien, Ewa ORCID logo
  11. Kunc, Michal
  12. Schneider, Dominik T. ORCID logo
  13. Cuk, Katarina
  14. Büttel, Isabel
  15. Flemmig, Carina
  16. Peters, Magdalena
  17. Laible, Mark
  18. Brück, Patrick
  19. Türeci, Özlem
  20. Sahin, Ugur
  21. Flatz, Lukas
  22. Brecht, Ines ORCID logo

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1000 Titel
  • Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study
1000 Autor/in
  1. Forchhammer, Stephan |
  2. Pop, Oltin-Tiberiu |
  3. Hahn, Matthias |
  4. Aebischer, Valentin |
  5. Seitz, Christian M. |
  6. Schroeder, Christopher |
  7. Liebmann, Alexandra |
  8. Abele, Michael |
  9. Wild, Hannah |
  10. Bien, Ewa |
  11. Kunc, Michal |
  12. Schneider, Dominik T. |
  13. Cuk, Katarina |
  14. Büttel, Isabel |
  15. Flemmig, Carina |
  16. Peters, Magdalena |
  17. Laible, Mark |
  18. Brück, Patrick |
  19. Türeci, Özlem |
  20. Sahin, Ugur |
  21. Flatz, Lukas |
  22. Brecht, Ines |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-06-18
1000 Erschienen in
1000 Quellenangabe
  • 485(2):335-346
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00428-024-03846-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329550/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Tumor-associated antigens (TAAs) are potential targets for T cell-based immunotherapy approaches in cutaneous melanoma. BNT111, an investigational lipoplex-formulated mRNA-based therapeutic cancer vaccine encoding melanoma TAAs NY-ESO-1, tyrosinase, MAGE-A3, and TPTE, is undergoing clinical testing in adults. Expression of these TAAs in pediatric melanoma is unclear but is a prerequisite for feasibility of this treatment approach in children with melanoma. Our main objective was to characterize expression of those TAAs in pediatric melanomas compared to control cohorts. In this retrospective case control study, protein and transcript expression of NY-ESO-1, tyrosinase, MAGE-A3, and TPTE were analyzed in a cohort of 25 pediatric melanomas, 31 melanomas of young adults, 29 adult melanomas, and 30 benign melanocytic nevi in children using immunohistochemical staining and digital pathology (QuPath) and reverse transcription quantitative PCR. Based on IHC analysis, pediatric melanomas expressed tyrosinase (100.0%), TPTE (44.0%), MAGE-A3 (12.0%), and NY-ESO-1 (8.0%). Young adult melanomas expressed tyrosinase (96.8%), NY-ESO-1 (19.4%), MAGE-A3 (19.4%), and TPTE (3.2%). Adult melanomas expressed tyrosinase (86.2%), MAGE-A3 (75.9%), NY-ESO-1 (48.3%), and TPTE (48.3%). Childhood melanocytic nevi only expressed tyrosinase (93.3%). Expression prevalence of individual TAAs did not differ between subtypes of pediatric melanoma, and no association with prognosis was found. All four TAAs were expressed in pediatric melanoma, albeit NY-ESO-1 and MAGE-A3 to a lesser extent than in adult melanoma. These data support the possibility of investigating vaccines targeting these TAAs for the treatment of pediatric melanoma.</jats:p>
1000 Sacherschließung
lokal Monophenol Monooxygenase/metabolism [MeSH]
lokal Aged [MeSH]
lokal Melanoma/metabolism [MeSH]
lokal Original Article
lokal Prognostic factor
lokal Infant [MeSH]
lokal Male [MeSH]
lokal Membrane Proteins/metabolism [MeSH]
lokal Melanoma/pathology [MeSH]
lokal Case-Control Studies [MeSH]
lokal Biomarkers, Tumor/analysis [MeSH]
lokal Child [MeSH]
lokal Membrane Proteins/genetics [MeSH]
lokal Cancer vaccine
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Neoplasm Proteins/metabolism [MeSH]
lokal Pediatric melanoma
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal Skin Neoplasms/pathology [MeSH]
lokal TAA
lokal Biomarkers, Tumor/metabolism [MeSH]
lokal Antigens, Neoplasm/metabolism [MeSH]
lokal Biomarkers, Tumor/genetics [MeSH]
lokal Young Adult [MeSH]
lokal Child, Preschool [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1274-2613|https://orcid.org/0000-0001-8000-2310|https://frl.publisso.de/adhoc/uri/SGFobiwgTWF0dGhpYXM=|https://orcid.org/0009-0000-7040-4949|https://frl.publisso.de/adhoc/uri/U2VpdHosIENocmlzdGlhbiBNLg==|https://frl.publisso.de/adhoc/uri/U2Nocm9lZGVyLCBDaHJpc3RvcGhlcg==|https://frl.publisso.de/adhoc/uri/TGllYm1hbm4sIEFsZXhhbmRyYQ==|https://orcid.org/0000-0002-9780-603X|https://frl.publisso.de/adhoc/uri/V2lsZCwgSGFubmFo|https://orcid.org/0000-0002-2091-2686|https://frl.publisso.de/adhoc/uri/S3VuYywgTWljaGFs|https://orcid.org/0000-0001-8153-1601|https://frl.publisso.de/adhoc/uri/Q3VrLCBLYXRhcmluYQ==|https://frl.publisso.de/adhoc/uri/QsO8dHRlbCwgSXNhYmVs|https://frl.publisso.de/adhoc/uri/RmxlbW1pZywgQ2FyaW5h|https://frl.publisso.de/adhoc/uri/UGV0ZXJzLCBNYWdkYWxlbmE=|https://frl.publisso.de/adhoc/uri/TGFpYmxlLCBNYXJr|https://frl.publisso.de/adhoc/uri/QnLDvGNrLCBQYXRyaWNr|https://frl.publisso.de/adhoc/uri/VMO8cmVjaSwgw5Z6bGVt|https://frl.publisso.de/adhoc/uri/U2FoaW4sIFVndXI=|https://frl.publisso.de/adhoc/uri/RmxhdHosIEx1a2Fz|https://orcid.org/0000-0001-7973-3300
1000 Hinweis
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1000 Förderer
  1. Universitätsklinikum Tübingen |
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    1000 Förderer Universitätsklinikum Tübingen |
    1000 Förderprogramm -
    1000 Fördernummer -
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1000 Erstellt am 2025-07-05T08:39:40.343+0200
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1000 Zuletzt bearbeitet 2025-08-19T18:56:57.021+0200
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