PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities

  1. Gorbokon, Natalia
  2. Baltruschat, Sarah
  3. Lennartz, Maximilian
  4. Luebke, Andreas M.
  5. Höflmayer, Doris
  6. Kluth, Martina
  7. Hube-Magg, Claudia
  8. Hinsch, Andrea
  9. Fraune, Christoph
  10. Lebok, Patrick
  11. Bernreuther, Christian
  12. Sauter, Guido
  13. Marx, Andreas H.
  14. Simon, Ronald ORCID logo
  15. Krech, Till
  16. Clauditz, Till S.
  17. Jacobsen, Frank
  18. Burandt, Eike
  19. Steurer, Stefan
  20. Minner, Sarah

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WeightNameValue
1000 Titel
  • PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities
1000 Autor/in
  1. Gorbokon, Natalia |
  2. Baltruschat, Sarah |
  3. Lennartz, Maximilian |
  4. Luebke, Andreas M. |
  5. Höflmayer, Doris |
  6. Kluth, Martina |
  7. Hube-Magg, Claudia |
  8. Hinsch, Andrea |
  9. Fraune, Christoph |
  10. Lebok, Patrick |
  11. Bernreuther, Christian |
  12. Sauter, Guido |
  13. Marx, Andreas H. |
  14. Simon, Ronald |
  15. Krech, Till |
  16. Clauditz, Till S. |
  17. Jacobsen, Frank |
  18. Burandt, Eike |
  19. Steurer, Stefan |
  20. Minner, Sarah |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-08-06
1000 Erschienen in
1000 Quellenangabe
  • 485(3):491-507
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00428-024-03872-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415470/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>PAX8 plays a role in development of the thyroid, kidney, and the Wolffian and Mullerian tract. In surgical pathology, PAX8 immunohistochemistry is used to determine tumors of renal and ovarian origin, but data on its expression in other tumors are conflicting. To evaluate PAX8 expression in normal and tumor tissues, a tissue microarray containing 17,386 samples from 149 different tumor types and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. PAX8 results were compared with previously collected data on cadherin 16 (CDH16). PAX8 positivity was found in 40 different tumor types. The highest rate of PAX8 positivity was found in thyroidal neoplasms of follicular origin (98.6–100%), gynecological carcinomas (up to 100%), renal tumors (82.6–97.8%), and urothelial neoplasms (2.3–23.7%). Important tumors with near complete absence of PAX8 staining (&lt; 1%) included all subtypes of breast cancers, hepatocellular carcinomas, gastric, prostatic, pancreatic, and pulmonary adenocarcinomas, neuroendocrine neoplasms, small cell carcinomas of various sites, and lymphomas. High PAX8 expression was associated with low tumor grade in 365 non-invasive papillary urothelial carcinomas (<jats:italic>p</jats:italic> &lt; 0.0001) but unrelated to patient outcome and/or tumor phenotype in clear cell renal cell carcinoma, high-grade serous ovarian cancer, and endometrioid endometrial carcinoma. For determining a renal tumor origin, sensitivity was 88.1% and specificity 87.2% for PAX8, while sensitivity was 85.3% and specificity 95.7% for CDH16. The combination of PAX8 and CDH16 increased specificity to 96.8%. In conclusion, PAX8 immunohistochemistry is a suitable diagnostic tool. The combination of PAX8 and CDH16 positivity has high specificity for renal cell carcinoma.</jats:p>
1000 Sacherschließung
lokal Female [MeSH]
lokal Immunohistochemistry
lokal Cancer
lokal Humans [MeSH]
lokal Diagnostic marker
lokal Neoplasms/diagnosis [MeSH]
lokal Tissue Array Analysis [MeSH]
lokal Tissue microarray
lokal Neoplasms/metabolism [MeSH]
lokal Immunohistochemistry [MeSH]
lokal Original Article
lokal Neoplasms/pathology [MeSH]
lokal PAX8
lokal Cadherins/analysis [MeSH]
lokal Biomarkers, Tumor/analysis [MeSH]
lokal PAX8 Transcription Factor/analysis [MeSH]
lokal Cadherins/metabolism [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Universitätsklinikum Hamburg-Eppendorf (UKE) |
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    1000 Förderer Universitätsklinikum Hamburg-Eppendorf (UKE) |
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1000 Erstellt am 2025-07-05T09:19:40.623+0200
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1000 Objekt bearb. Fri Aug 15 19:43:59 CEST 2025
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