Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma

  1. Drexler, Richard ORCID logo
  2. Khatri, Robin
  3. Schüller, Ulrich
  4. Eckhardt, Alicia
  5. Ryba, Alice
  6. Sauvigny, Thomas
  7. Dührsen, Lasse
  8. Mohme, Malte
  9. Ricklefs, Tammo
  10. Bode, Helena
  11. Hausmann, Fabian
  12. Huber, Tobias B.
  13. Bonn, Stefan
  14. Voß, Hannah
  15. Neumann, Julia E.
  16. Silverbush, Dana
  17. Hovestadt, Volker
  18. Suvà, Mario L.
  19. Lamszus, Katrin
  20. Gempt, Jens
  21. Westphal, Manfred
  22. Heiland, Dieter H.
  23. Hänzelmann, Sonja
  24. Ricklefs, Franz L.

Download
00401_2024_Article_2677.pdf 3,17MB
WeightNameValue
1000 Titel
  • Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
1000 Autor/in
  1. Drexler, Richard |
  2. Khatri, Robin |
  3. Schüller, Ulrich |
  4. Eckhardt, Alicia |
  5. Ryba, Alice |
  6. Sauvigny, Thomas |
  7. Dührsen, Lasse |
  8. Mohme, Malte |
  9. Ricklefs, Tammo |
  10. Bode, Helena |
  11. Hausmann, Fabian |
  12. Huber, Tobias B. |
  13. Bonn, Stefan |
  14. Voß, Hannah |
  15. Neumann, Julia E. |
  16. Silverbush, Dana |
  17. Hovestadt, Volker |
  18. Suvà, Mario L. |
  19. Lamszus, Katrin |
  20. Gempt, Jens |
  21. Westphal, Manfred |
  22. Heiland, Dieter H. |
  23. Hänzelmann, Sonja |
  24. Ricklefs, Franz L. |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-01-20
1000 Erschienen in
1000 Quellenangabe
  • 147(1):21
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00401-023-02677-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799798/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>The longitudinal transition of phenotypes is pivotal in glioblastoma treatment resistance and DNA methylation emerged as an important tool for classifying glioblastoma phenotypes. We aimed to characterize DNA methylation subclass heterogeneity during progression and assess its clinical impact. Matched tissues from 47 glioblastoma patients were subjected to DNA methylation profiling, including CpG-site alterations, tissue and serum deconvolution, mass spectrometry, and immunoassay. Effects of clinical characteristics on temporal changes and outcomes were studied. Among 47 patients, 8 (17.0%) had non-matching classifications at recurrence. In the remaining 39 cases, 28.2% showed dominant DNA methylation subclass transitions, with 72.7% being a mesenchymal subclass. In general, glioblastomas with a subclass transition showed upregulated metabolic processes. Newly diagnosed glioblastomas with mesenchymal transition displayed increased stem cell-like states and decreased immune components at diagnosis and exhibited elevated immune signatures and cytokine levels in serum. In contrast, tissue of recurrent glioblastomas with mesenchymal transition showed increased immune components but decreased stem cell-like states. Survival analyses revealed comparable outcomes for patients with and without subclass transitions. This study demonstrates a temporal heterogeneity of DNA methylation subclasses in 28.2% of glioblastomas, not impacting patient survival. Changes in cell state composition associated with subclass transition may be crucial for recurrent glioblastoma targeted therapies.</jats:p>
1000 Sacherschließung
lokal Deconvolution
lokal Glioma
lokal Outcome
lokal Subgroup
lokal Humans [MeSH]
lokal Survival Analysis [MeSH]
lokal Temporal
lokal Glioblastoma/therapy [MeSH]
lokal Brain Neoplasms [MeSH]
lokal DNA Methylation [MeSH]
lokal Original Paper
lokal Neoplasm Recurrence, Local/genetics [MeSH]
lokal DNA methylation
lokal Glioblastoma/genetics [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-4830-3671|https://frl.publisso.de/adhoc/uri/S2hhdHJpLCBSb2Jpbg==|https://frl.publisso.de/adhoc/uri/U2Now7xsbGVyLCBVbHJpY2g=|https://frl.publisso.de/adhoc/uri/RWNraGFyZHQsIEFsaWNpYQ==|https://frl.publisso.de/adhoc/uri/UnliYSwgQWxpY2U=|https://frl.publisso.de/adhoc/uri/U2F1dmlnbnksIFRob21hcw==|https://frl.publisso.de/adhoc/uri/RMO8aHJzZW4sIExhc3Nl|https://frl.publisso.de/adhoc/uri/TW9obWUsIE1hbHRl|https://frl.publisso.de/adhoc/uri/Umlja2xlZnMsIFRhbW1v|https://frl.publisso.de/adhoc/uri/Qm9kZSwgSGVsZW5h|https://frl.publisso.de/adhoc/uri/SGF1c21hbm4sIEZhYmlhbg==|https://frl.publisso.de/adhoc/uri/SHViZXIsIFRvYmlhcyBCLg==|https://frl.publisso.de/adhoc/uri/Qm9ubiwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/Vm-DnywgSGFubmFo|https://frl.publisso.de/adhoc/uri/TmV1bWFubiwgSnVsaWEgRS4=|https://frl.publisso.de/adhoc/uri/U2lsdmVyYnVzaCwgRGFuYQ==|https://frl.publisso.de/adhoc/uri/SG92ZXN0YWR0LCBWb2xrZXI=|https://frl.publisso.de/adhoc/uri/U3V2w6AsIE1hcmlvIEwu|https://frl.publisso.de/adhoc/uri/TGFtc3p1cywgS2F0cmlu|https://frl.publisso.de/adhoc/uri/R2VtcHQsIEplbnM=|https://frl.publisso.de/adhoc/uri/V2VzdHBoYWwsIE1hbmZyZWQ=|https://frl.publisso.de/adhoc/uri/SGVpbGFuZCwgRGlldGVyIEgu|https://frl.publisso.de/adhoc/uri/SMOkbnplbG1hbm4sIFNvbmph|https://frl.publisso.de/adhoc/uri/Umlja2xlZnMsIEZyYW56IEwu
1000 Hinweis
  • DeepGreen-ID: 13d8e9cea0e745eeb84066820b4d577f ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. Fördergemeinschaft Kinderkrebs-Zentrum Hamburg |
  2. Illumina |
  3. HORIZON EUROPE Excellent Science |
  4. Deutsche Forschungsgemeinschaft |
  5. Universitätsklinikum Hamburg-Eppendorf (UKE) |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
  5. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Fördergemeinschaft Kinderkrebs-Zentrum Hamburg |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Illumina |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer HORIZON EUROPE Excellent Science |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Universitätsklinikum Hamburg-Eppendorf (UKE) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6518326.rdf
1000 Erstellt am 2025-07-05T10:25:13.254+0200
1000 Erstellt von 322
1000 beschreibt frl:6518326
1000 Zuletzt bearbeitet 2025-08-19T19:56:47.055+0200
1000 Objekt bearb. Tue Aug 19 19:56:47 CEST 2025
1000 Vgl. frl:6518326
1000 Oai Id
  1. oai:frl.publisso.de:frl:6518326 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source