CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes

  1. Schnell, Oliver
  2. Barnard-Kelly, Katharine
  3. Battelino, Tadej
  4. Ceriello, Antonio
  5. Larsson, Helena Elding
  6. Fernández-Fernández, Beatriz
  7. Forst, Thomas
  8. Frias, Juan-Pablo
  9. Gavin, James R.
  10. Giorgino, Francesco
  11. Groop, Per-Henrik
  12. Heerspink, Hiddo J. L.
  13. Herzig, Stephan
  14. Hummel, Michael
  15. Huntley, George
  16. Ibrahim, Mahmoud
  17. Itzhak, Baruch
  18. Jacob, Stephan
  19. Ji, Linong
  20. Kosiborod, Mikhail
  21. Lalic, Nebosja
  22. Macieira, Sofia
  23. Malik, Rayaz A.
  24. Mankovsky, Boris
  25. Marx, Nikolaus
  26. Mathieu, Chantal
  27. Müller, Timo D.
  28. Ray, Kausik
  29. Rodbard, Helena W.
  30. Rossing, Peter
  31. Rydén, Lars
  32. Schumm-Draeger, Petra-Maria
  33. Schwarz, Peter
  34. Škrha, Jan
  35. Snoek, Frank
  36. Tacke, Frank
  37. Taylor, Bruce
  38. Jeppesen, Britta Tendal
  39. Tesfaye, Solomon
  40. Topsever, Pinar
  41. Vilsbøll, Tina
  42. Yu, Xuefeng
  43. Standl, Eberhard

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1000 Titel
  • CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes
1000 Autor/in
  1. Schnell, Oliver |
  2. Barnard-Kelly, Katharine |
  3. Battelino, Tadej |
  4. Ceriello, Antonio |
  5. Larsson, Helena Elding |
  6. Fernández-Fernández, Beatriz |
  7. Forst, Thomas |
  8. Frias, Juan-Pablo |
  9. Gavin, James R. |
  10. Giorgino, Francesco |
  11. Groop, Per-Henrik |
  12. Heerspink, Hiddo J. L. |
  13. Herzig, Stephan |
  14. Hummel, Michael |
  15. Huntley, George |
  16. Ibrahim, Mahmoud |
  17. Itzhak, Baruch |
  18. Jacob, Stephan |
  19. Ji, Linong |
  20. Kosiborod, Mikhail |
  21. Lalic, Nebosja |
  22. Macieira, Sofia |
  23. Malik, Rayaz A. |
  24. Mankovsky, Boris |
  25. Marx, Nikolaus |
  26. Mathieu, Chantal |
  27. Müller, Timo D. |
  28. Ray, Kausik |
  29. Rodbard, Helena W. |
  30. Rossing, Peter |
  31. Rydén, Lars |
  32. Schumm-Draeger, Petra-Maria |
  33. Schwarz, Peter |
  34. Škrha, Jan |
  35. Snoek, Frank |
  36. Tacke, Frank |
  37. Taylor, Bruce |
  38. Jeppesen, Britta Tendal |
  39. Tesfaye, Solomon |
  40. Topsever, Pinar |
  41. Vilsbøll, Tina |
  42. Yu, Xuefeng |
  43. Standl, Eberhard |
1000 Verlag BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-03-19
1000 Erschienen in
1000 Quellenangabe
  • 23(1):104
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12933-024-02180-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953147/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT and STEP-HFpEF) and bempedoic acid (CLEAR Outcomes), and the advances they represent in reducing the risk of major adverse cardiovascular events (MACE), improving metabolic outcomes, and treating obesity-related heart failure with preserved ejection fraction (HFpEF). A broad audience of endocrinologists, diabetologists, cardiologists, nephrologists and primary care physicians participated in online discussions on guideline updates for the management of cardiovascular disease (CVD) in diabetes, heart failure (HF) and chronic kidney disease (CKD); advances in the management of type 1 diabetes (T1D) and its comorbidities; advances in the management of CKD with SGLT2 inhibitors and non-steroidal mineralocorticoid receptor antagonists (nsMRAs); and advances in the treatment of obesity with GLP-1 and dual GIP/GLP-1 receptor agonists. The association of diabetes and obesity with nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis, MASH) and cancer and possible treatments for these complications were also explored. It is generally assumed that treatment of chronic diseases is equally effective for all patients. However, as discussed at the Summit, this assumption may not be true. Therefore, it is important to enroll patients from diverse racial and ethnic groups in clinical trials and to analyze patient-reported outcomes to assess treatment efficacy, and to develop innovative approaches to tailor medications to those who benefit most with minimal side effects. Other keys to a successful management of diabetes and comorbidities, including dementia, entail the use of continuous glucose monitoring (CGM) technology and the implementation of appropriate patient-physician communication strategies. The 10th Cardiovascular Outcome Trial Summit will be held virtually on December 5–6, 2024 (<jats:ext-link xmlns:xlink='http://www.w3.org/1999/xlink' ext-link-type='uri' xlink:href='http://www.cvot.org'>http://www.cvot.org</jats:ext-link>).</jats:p>
1000 Sacherschließung
lokal Renal Insufficiency, Chronic/diagnosis [MeSH]
lokal Heart failure
lokal Blood Glucose Self-Monitoring [MeSH]
lokal Cardiovascular disease
lokal Cardiovascular Diseases/diagnosis [MeSH]
lokal Diabetes Mellitus, Type 2/drug therapy [MeSH]
lokal Finerenone
lokal Blood Glucose [MeSH]
lokal GLP-1 RA
lokal Chronic kidney disease
lokal Diabetes Mellitus/drug therapy [MeSH]
lokal Stroke Volume [MeSH]
lokal Comment
lokal Obesity
lokal Humans [MeSH]
lokal Guidelines
lokal Cardiovascular Diseases/epidemiology [MeSH]
lokal Kidney [MeSH]
lokal Cardiovascular Diseases/prevention
lokal Teplizumab
lokal Heart Failure/complications [MeSH]
lokal Obesity/complications [MeSH]
lokal Diabetes
lokal SGLT2 inhibitor
lokal MASLD
lokal Renal Insufficiency, Chronic/therapy [MeSH]
lokal CGM
lokal Renal Insufficiency, Chronic/epidemiology [MeSH]
lokal NAFLD
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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