Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

  1. Choudhary, Priyanka ORCID logo
  2. Monasso, Giulietta S.
  3. Karhunen, Ville ORCID logo
  4. Ronkainen, Justiina
  5. Mancano, Giulia
  6. Howe, Caitlin ORCID logo
  7. Niu, Zhongzheng
  8. Zeng, Xuehuo
  9. Guan, Weihua
  10. Dou, John
  11. Feinberg, Jason ORCID logo
  12. Mordaunt, Charles
  13. Pesce, Giancarlo ORCID logo
  14. Baïz, Nour
  15. Alfano, Rossella
  16. Martens, Dries S.
  17. Wang, Congrong
  18. Isaevska, Elena
  19. Keikkala, Elina
  20. Mustaniemi, Sanna
  21. Thio, Chris H. L.
  22. Fraszczyk, Eliza
  23. Tobi, Elmar W.
  24. Starling, Anne P.
  25. Cosín-Tomàs, Marta ORCID logo
  26. Urquiza, Jose
  27. Roeder, Stefan ORCID logo
  28. Hoang, Thanh T. ORCID logo
  29. Page, Christian
  30. Jima, Dereje ORCID logo
  31. House, John S. ORCID logo
  32. Maguire, Rachel L.
  33. Ott, Raffael
  34. Pawlow, Xenia
  35. Sirignano, Lea ORCID logo
  36. Zillich, Lea ORCID logo
  37. Malmberg, Anni
  38. Rauschert, Sebastian
  39. Melton, Phillip ORCID logo
  40. Gong, Tong
  41. Karlsson, Robert ORCID logo
  42. Fore, Ruby
  43. Perng, Wei
  44. Laubach, Zachary M.
  45. Czamara, Darina ORCID logo
  46. Sharp, Gemma
  47. Breton, Carrie V.
  48. Schisterman, Enrique
  49. Yeung, Edwina
  50. Mumford, Sunni L.
  51. Fallin, M. Daniele
  52. LaSalle, Janine ORCID logo
  53. Schmidt, Rebecca J. ORCID logo
  54. Bakulski, Kelly ORCID logo
  55. Annesi-Maesano, Isabella ORCID logo
  56. Heude, Barbara ORCID logo
  57. Nawrot, Tim S.
  58. Plusquin, Michelle
  59. Ghantous, Akram
  60. Herceg, Zdenko
  61. Nisticò, Lorenza
  62. Vafeiadi, Marina ORCID logo
  63. Kogevinas, Manolis
  64. Vääräsmäki, Marja
  65. Kajantie, Eero
  66. Snieder, Harold ORCID logo
  67. Corpeleijn, Eva
  68. Steegers-Theunissen, Regine P. M.
  69. Yang, Ivana V.
  70. Dabelea, Dana
  71. Fossati, Serena
  72. Zenclussen, Ana C.
  73. Herberth, Gunda ORCID logo
  74. Magnus, Maria
  75. Håberg, Siri E.
  76. London, Stephanie ORCID logo
  77. Munthe-Kaas, Monica Cheng
  78. Murphy, Susan ORCID logo
  79. Hoyo, Cathrine
  80. Ziegler, Anette-G
  81. Hummel, Sandra
  82. Witt, Stephanie ORCID logo
  83. Streit, Fabian ORCID logo
  84. Frank, Josef ORCID logo
  85. Räikkönen, Katri
  86. Lahti, Jari ORCID logo
  87. Huang, Rae-chi
  88. Almqvist, Catarina
  89. Hivert, Marie-France ORCID logo
  90. Jaddoe, Vincent ORCID logo
  91. Jarvelin, Marjo-Riitta ORCID logo
  92. Kantomaa, Marko
  93. Felix, Janine ORCID logo
  94. Sebert, Sylvain ORCID logo

Download
41380_2023_Article_2331.pdf 1,89MB
WeightNameValue
1000 Titel
  • Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
1000 Autor/in
  1. Choudhary, Priyanka |
  2. Monasso, Giulietta S. |
  3. Karhunen, Ville |
  4. Ronkainen, Justiina |
  5. Mancano, Giulia |
  6. Howe, Caitlin |
  7. Niu, Zhongzheng |
  8. Zeng, Xuehuo |
  9. Guan, Weihua |
  10. Dou, John |
  11. Feinberg, Jason |
  12. Mordaunt, Charles |
  13. Pesce, Giancarlo |
  14. Baïz, Nour |
  15. Alfano, Rossella |
  16. Martens, Dries S. |
  17. Wang, Congrong |
  18. Isaevska, Elena |
  19. Keikkala, Elina |
  20. Mustaniemi, Sanna |
  21. Thio, Chris H. L. |
  22. Fraszczyk, Eliza |
  23. Tobi, Elmar W. |
  24. Starling, Anne P. |
  25. Cosín-Tomàs, Marta |
  26. Urquiza, Jose |
  27. Roeder, Stefan |
  28. Hoang, Thanh T. |
  29. Page, Christian |
  30. Jima, Dereje |
  31. House, John S. |
  32. Maguire, Rachel L. |
  33. Ott, Raffael |
  34. Pawlow, Xenia |
  35. Sirignano, Lea |
  36. Zillich, Lea |
  37. Malmberg, Anni |
  38. Rauschert, Sebastian |
  39. Melton, Phillip |
  40. Gong, Tong |
  41. Karlsson, Robert |
  42. Fore, Ruby |
  43. Perng, Wei |
  44. Laubach, Zachary M. |
  45. Czamara, Darina |
  46. Sharp, Gemma |
  47. Breton, Carrie V. |
  48. Schisterman, Enrique |
  49. Yeung, Edwina |
  50. Mumford, Sunni L. |
  51. Fallin, M. Daniele |
  52. LaSalle, Janine |
  53. Schmidt, Rebecca J. |
  54. Bakulski, Kelly |
  55. Annesi-Maesano, Isabella |
  56. Heude, Barbara |
  57. Nawrot, Tim S. |
  58. Plusquin, Michelle |
  59. Ghantous, Akram |
  60. Herceg, Zdenko |
  61. Nisticò, Lorenza |
  62. Vafeiadi, Marina |
  63. Kogevinas, Manolis |
  64. Vääräsmäki, Marja |
  65. Kajantie, Eero |
  66. Snieder, Harold |
  67. Corpeleijn, Eva |
  68. Steegers-Theunissen, Regine P. M. |
  69. Yang, Ivana V. |
  70. Dabelea, Dana |
  71. Fossati, Serena |
  72. Zenclussen, Ana C. |
  73. Herberth, Gunda |
  74. Magnus, Maria |
  75. Håberg, Siri E. |
  76. London, Stephanie |
  77. Munthe-Kaas, Monica Cheng |
  78. Murphy, Susan |
  79. Hoyo, Cathrine |
  80. Ziegler, Anette-G |
  81. Hummel, Sandra |
  82. Witt, Stephanie |
  83. Streit, Fabian |
  84. Frank, Josef |
  85. Räikkönen, Katri |
  86. Lahti, Jari |
  87. Huang, Rae-chi |
  88. Almqvist, Catarina |
  89. Hivert, Marie-France |
  90. Jaddoe, Vincent |
  91. Jarvelin, Marjo-Riitta |
  92. Kantomaa, Marko |
  93. Felix, Janine |
  94. Sebert, Sylvain |
1000 Verlag Nature Publishing Group UK
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-12-05
1000 Erschienen in
1000 Quellenangabe
  • 29(2):348-358
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41380-023-02331-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116099/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (<jats:italic>n</jats:italic> = 9 881), in childhood (<jats:italic>n</jats:italic> = 2 017), and adolescence (<jats:italic>n</jats:italic> = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B<jats:sub>12</jats:sub> concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.</jats:p>
1000 Sacherschließung
lokal Academic Success [MeSH]
lokal DNA Methylation/genetics [MeSH]
lokal Infant, Newborn [MeSH]
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Prenatal Exposure Delayed Effects/genetics [MeSH]
lokal /631/208
lokal Epigenome/genetics [MeSH]
lokal Adult [MeSH]
lokal Educational Status [MeSH]
lokal Humans [MeSH]
lokal /692/53/2423
lokal Article
lokal Genome-Wide Association Study/methods [MeSH]
lokal Infant [MeSH]
lokal Male [MeSH]
lokal Mothers [MeSH]
lokal Epigenesis, Genetic/genetics [MeSH]
lokal Child [MeSH]
lokal Pregnancy [MeSH]
lokal article
lokal Child, Preschool [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2420-4118|https://frl.publisso.de/adhoc/uri/TW9uYXNzbywgR2l1bGlldHRhIFMu|https://orcid.org/0000-0001-6064-1588|https://frl.publisso.de/adhoc/uri/Um9ua2FpbmVuLCBKdXN0aWluYQ==|https://frl.publisso.de/adhoc/uri/TWFuY2FubywgR2l1bGlh|https://orcid.org/0000-0002-4935-9298|https://frl.publisso.de/adhoc/uri/Tml1LCBaaG9uZ3poZW5n|https://frl.publisso.de/adhoc/uri/WmVuZywgWHVlaHVv|https://frl.publisso.de/adhoc/uri/R3VhbiwgV2VpaHVh|https://frl.publisso.de/adhoc/uri/RG91LCBKb2hu|https://orcid.org/0000-0002-6556-3635|https://frl.publisso.de/adhoc/uri/TW9yZGF1bnQsIENoYXJsZXM=|https://orcid.org/0000-0003-4925-6325|https://frl.publisso.de/adhoc/uri/QmHDr3osIE5vdXI=|https://frl.publisso.de/adhoc/uri/QWxmYW5vLCBSb3NzZWxsYQ==|https://frl.publisso.de/adhoc/uri/TWFydGVucywgRHJpZXMgUy4=|https://frl.publisso.de/adhoc/uri/V2FuZywgQ29uZ3Jvbmc=|https://frl.publisso.de/adhoc/uri/SXNhZXZza2EsIEVsZW5h|https://frl.publisso.de/adhoc/uri/S2Vpa2thbGEsIEVsaW5h|https://frl.publisso.de/adhoc/uri/TXVzdGFuaWVtaSwgU2FubmE=|https://frl.publisso.de/adhoc/uri/VGhpbywgQ2hyaXMgSC4gTC4=|https://frl.publisso.de/adhoc/uri/RnJhc3pjenlrLCBFbGl6YQ==|https://frl.publisso.de/adhoc/uri/VG9iaSwgRWxtYXIgVy4=|https://frl.publisso.de/adhoc/uri/U3RhcmxpbmcsIEFubmUgUC4=|https://orcid.org/0000-0001-5012-8983|https://frl.publisso.de/adhoc/uri/VXJxdWl6YSwgSm9zZQ==|https://orcid.org/0000-0001-9367-663X|https://orcid.org/0000-0002-8498-0020|https://frl.publisso.de/adhoc/uri/UGFnZSwgQ2hyaXN0aWFu|https://orcid.org/0000-0002-7784-1612|https://orcid.org/0000-0002-8447-7871|https://frl.publisso.de/adhoc/uri/TWFndWlyZSwgUmFjaGVsIEwu|https://frl.publisso.de/adhoc/uri/T3R0LCBSYWZmYWVs|https://frl.publisso.de/adhoc/uri/UGF3bG93LCBYZW5pYQ==|https://orcid.org/0000-0002-7989-5833|https://orcid.org/0000-0001-7457-374X|https://frl.publisso.de/adhoc/uri/TWFsbWJlcmcsIEFubmk=|https://frl.publisso.de/adhoc/uri/UmF1c2NoZXJ0LCBTZWJhc3RpYW4=|https://orcid.org/0000-0003-4026-2964|https://frl.publisso.de/adhoc/uri/R29uZywgVG9uZw==|https://orcid.org/0000-0002-8949-2587|https://frl.publisso.de/adhoc/uri/Rm9yZSwgUnVieQ==|https://frl.publisso.de/adhoc/uri/UGVybmcsIFdlaQ==|https://frl.publisso.de/adhoc/uri/TGF1YmFjaCwgWmFjaGFyeSBNLg==|https://orcid.org/0000-0001-7381-904X|https://frl.publisso.de/adhoc/uri/U2hhcnAsIEdlbW1h|https://frl.publisso.de/adhoc/uri/QnJldG9uLCBDYXJyaWUgVi4=|https://frl.publisso.de/adhoc/uri/U2NoaXN0ZXJtYW4sIEVucmlxdWU=|https://frl.publisso.de/adhoc/uri/WWV1bmcsIEVkd2luYQ==|https://frl.publisso.de/adhoc/uri/TXVtZm9yZCwgU3VubmkgTC4=|https://frl.publisso.de/adhoc/uri/RmFsbGluLCBNLiBEYW5pZWxl|https://orcid.org/0000-0002-3480-2031|https://orcid.org/0000-0003-1582-2747|https://orcid.org/0000-0002-9605-6337|https://orcid.org/0000-0002-6340-9300|https://orcid.org/0000-0002-1565-1629|https://frl.publisso.de/adhoc/uri/TmF3cm90LCBUaW0gUy4=|https://frl.publisso.de/adhoc/uri/UGx1c3F1aW4sIE1pY2hlbGxl|https://frl.publisso.de/adhoc/uri/R2hhbnRvdXMsIEFrcmFt|https://frl.publisso.de/adhoc/uri/SGVyY2VnLCBaZGVua28=|https://frl.publisso.de/adhoc/uri/TmlzdGljw7IsIExvcmVuemE=|https://orcid.org/0000-0002-6143-7172|https://frl.publisso.de/adhoc/uri/S29nZXZpbmFzLCBNYW5vbGlz|https://frl.publisso.de/adhoc/uri/VsOkw6Ryw6RzbcOka2ksIE1hcmph|https://frl.publisso.de/adhoc/uri/S2FqYW50aWUsIEVlcm8=|https://orcid.org/0000-0003-1949-2298|https://frl.publisso.de/adhoc/uri/Q29ycGVsZWlqbiwgRXZh|https://frl.publisso.de/adhoc/uri/U3RlZWdlcnMtVGhldW5pc3NlbiwgUmVnaW5lIFAuIE0u|https://frl.publisso.de/adhoc/uri/WWFuZywgSXZhbmEgVi4=|https://frl.publisso.de/adhoc/uri/RGFiZWxlYSwgRGFuYQ==|https://frl.publisso.de/adhoc/uri/Rm9zc2F0aSwgU2VyZW5h|https://frl.publisso.de/adhoc/uri/WmVuY2x1c3NlbiwgQW5hIEMu|https://orcid.org/0000-0003-0212-3509|https://frl.publisso.de/adhoc/uri/TWFnbnVzLCBNYXJpYQ==|https://frl.publisso.de/adhoc/uri/SMOlYmVyZywgU2lyaSBFLg==|https://orcid.org/0000-0003-4911-5290|https://frl.publisso.de/adhoc/uri/TXVudGhlLUthYXMsIE1vbmljYSBDaGVuZw==|https://orcid.org/0000-0001-8298-7272|https://frl.publisso.de/adhoc/uri/SG95bywgQ2F0aHJpbmU=|https://frl.publisso.de/adhoc/uri/WmllZ2xlciwgQW5ldHRlLUc=|https://frl.publisso.de/adhoc/uri/SHVtbWVsLCBTYW5kcmE=|https://orcid.org/0000-0002-1571-1468|https://orcid.org/0000-0003-1080-4339|https://orcid.org/0000-0003-4867-9465|https://frl.publisso.de/adhoc/uri/UsOkaWtrw7ZuZW4sIEthdHJp|https://orcid.org/0000-0002-4310-5297|https://frl.publisso.de/adhoc/uri/SHVhbmcsIFJhZS1jaGk=|https://frl.publisso.de/adhoc/uri/QWxtcXZpc3QsIENhdGFyaW5h|https://orcid.org/0000-0001-7752-2585|https://orcid.org/0000-0003-2939-0041|https://orcid.org/0000-0002-2149-0630|https://frl.publisso.de/adhoc/uri/S2FudG9tYWEsIE1hcmtv|https://orcid.org/0000-0002-9801-5774|https://orcid.org/0000-0001-6681-6983
1000 Hinweis
  • DeepGreen-ID: 427aabe1cae0400b8dde18d99e1beb01 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Förderer
  1. Horizon 2020 Framework Programme |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Horizon 2020 Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6519689.rdf
1000 Erstellt am 2025-07-05T19:40:26.184+0200
1000 Erstellt von 322
1000 beschreibt frl:6519689
1000 Zuletzt bearbeitet 2025-08-14T07:38:35.894+0200
1000 Objekt bearb. Thu Aug 14 07:38:35 CEST 2025
1000 Vgl. frl:6519689
1000 Oai Id
  1. oai:frl.publisso.de:frl:6519689 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source