Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron—results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)

  1. Hopff, Sina M.
  2. Appel, Katharina S.
  3. Miljukov, Olga
  4. Schneider, Johannes
  5. Addo, Marylyn M.
  6. Bals, Robert
  7. Bercker, Sven
  8. Blaschke, Sabine
  9. Bröhl, Isabel
  10. Büchner, Nikolaus
  11. Dashti, Hiwa
  12. Erber, Johanna
  13. Friedrichs, Anette
  14. Geisler, Ramsia
  15. Göpel, Siri
  16. Hagen, Marina
  17. Hanses, Frank
  18. Jensen, Björn-Erik Ole
  19. Keul, Maria
  20. Krawczyk, Adalbert
  21. Lorenz-Depiereux, Bettina
  22. Meybohm, Patrick
  23. Milovanovic, Milena
  24. Mitrov, Lazar
  25. Nürnberger, Carolin
  26. Obst, Wilfried
  27. Römmele, Christoph
  28. Schäfer, Christian
  29. Scheer, Christian
  30. Scherer, Margarete
  31. Schmidt, Julia
  32. Seibel, Kristina
  33. Sikdar, Shimita
  34. Tebbe, Johannes Josef
  35. Tepasse, Phil-Robin
  36. Thelen, Philipp
  37. Vehreschild, Maria J. G. T.
  38. Weismantel, Christina
  39. Vehreschild, J. Janne

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1000 Titel
  • Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron—results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)
1000 Autor/in
  1. Hopff, Sina M. |
  2. Appel, Katharina S. |
  3. Miljukov, Olga |
  4. Schneider, Johannes |
  5. Addo, Marylyn M. |
  6. Bals, Robert |
  7. Bercker, Sven |
  8. Blaschke, Sabine |
  9. Bröhl, Isabel |
  10. Büchner, Nikolaus |
  11. Dashti, Hiwa |
  12. Erber, Johanna |
  13. Friedrichs, Anette |
  14. Geisler, Ramsia |
  15. Göpel, Siri |
  16. Hagen, Marina |
  17. Hanses, Frank |
  18. Jensen, Björn-Erik Ole |
  19. Keul, Maria |
  20. Krawczyk, Adalbert |
  21. Lorenz-Depiereux, Bettina |
  22. Meybohm, Patrick |
  23. Milovanovic, Milena |
  24. Mitrov, Lazar |
  25. Nürnberger, Carolin |
  26. Obst, Wilfried |
  27. Römmele, Christoph |
  28. Schäfer, Christian |
  29. Scheer, Christian |
  30. Scherer, Margarete |
  31. Schmidt, Julia |
  32. Seibel, Kristina |
  33. Sikdar, Shimita |
  34. Tebbe, Johannes Josef |
  35. Tepasse, Phil-Robin |
  36. Thelen, Philipp |
  37. Vehreschild, Maria J. G. T. |
  38. Weismantel, Christina |
  39. Vehreschild, J. Janne |
1000 Verlag Springer Berlin Heidelberg
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-05-03
1000 Erschienen in
1000 Quellenangabe
  • 52(6):2253-2267
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s15010-024-02270-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621170/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95% CI 0.73–0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU.</jats:p> </jats:sec><jats:sec> <jats:title>Clinical Trail registration</jats:title> <jats:p>The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).</jats:p> </jats:sec>
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Female [MeSH]
lokal Multicenter prospective cohort study
lokal Health-related quality of life
lokal Aged [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Middle Aged [MeSH]
lokal Risk Factors [MeSH]
lokal Post-Acute COVID-19 Syndrome [MeSH]
lokal Germany/epidemiology [MeSH]
lokal Cohort Studies [MeSH]
lokal SARS-CoV-2 variants
lokal Male [MeSH]
lokal Quality of Life [MeSH]
lokal Research
lokal Post-covid-19 condition
lokal Prevalence [MeSH]
lokal COVID-19/epidemiology [MeSH]
lokal SARS-CoV-2 [MeSH]
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