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1000
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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>To evaluate T1ρ relaxation mapping in patients with symptomatic talar osteochondral lesions (OLT) and healthy controls (HC) at rest, with axial loading and traction.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Participants underwent 3-T ankle magnetic resonance imaging at rest and with 500 N loading and 120 N traction, without axial traction for a subcohort of 17/29 HC. We used a fast low-angle shot sequence with variable spin-lock intervals for monoexponential T1ρ fitting. Cartilage was manually segmented to extract T1ρ values.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>We studied 29 OLT patients (age 31.7 ± 7.5 years, 15 females, body mass index [BMI] 25.0 ± 3.4 kg/m<jats:sup>2</jats:sup>) and 29 HC (age 25.2 ± 4.3 years, 17 females, BMI 22.5 ± 2.3 kg/m<jats:sup>2</jats:sup>. T1ρ values of OLT (50.4 ± 3.4 ms) were higher than those of intact cartilage regions of OLT patients (47.2 ± 3.4 ms; <jats:italic>p</jats:italic> = 0.003) and matched HC cartilage (48.1 ± 3.3 ms; <jats:italic>p</jats:italic> = 0.030). Axial loading and traction induced significant T1ρ changes in the intact cartilage regions of patients (loading, mean difference -1.1 ms; traction, mean difference 1.4 ms; <jats:italic>p</jats:italic> = 0.030 for both) and matched HC cartilage (-2.2 ms, <jats:italic>p</jats:italic> = 0.003; 2.3 ms, <jats:italic>p</jats:italic> = 0.030; respectively), but not in the OLT itself (-1.3 ms; <jats:italic>p</jats:italic> = 0.150; +1.9 ms; <jats:italic>p</jats:italic> = 0.150; respectively).</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Increased T1ρ values may serve as a biomarker of cartilage degeneration in OLT. The absence of load- and traction-induced T1ρ changes in OLT compared to intact cartilage suggests that T1ρ may reflect altered biomechanical properties of hyaline cartilage.</jats:p>
</jats:sec><jats:sec>
<jats:title>Trial registration</jats:title>
<jats:p>DRKS, DRKS00024010. Registered 11 January 2021, <jats:ext-link xmlns:xlink='http://www.w3.org/1999/xlink' ext-link-type='uri' xlink:href='https://drks.de/search/de/trial/DRKS00024010'>https://drks.de/search/de/trial/DRKS00024010</jats:ext-link>.</jats:p>
</jats:sec><jats:sec>
<jats:title>Relevance statement</jats:title>
<jats:p>T1ρ mapping has the potential to evaluate compositional and biomechanical properties of the talar cartilage and may improve therapeutic decision-making in patients with osteochondral lesions.</jats:p>
</jats:sec><jats:sec>
<jats:title>Key Points</jats:title>
<jats:p><jats:list list-type='bullet'>
<jats:list-item>
<jats:p>T1ρ values in osteochondral lesions increased compared to intact cartilage.</jats:p>
</jats:list-item>
<jats:list-item>
<jats:p>Significant load- and traction-induced T1ρ changes were observed in visually intact regions and in healthy controls but not in osteochondral lesions.</jats:p>
</jats:list-item>
<jats:list-item>
<jats:p>T1ρ may serve as an imaging biomarker for biomechanical properties of cartilage.</jats:p>
</jats:list-item>
</jats:list></jats:p>
</jats:sec><jats:sec>
<jats:title>Graphical Abstract</jats:title>
</jats:sec>
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1000
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Hinweis
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DeepGreen-ID: e11f90c6286f4bbc8af930430a063b32 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search) ;
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