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1000 Titel
  • Paclitaxel and its semi-synthetic derivatives: comprehensive insights into chemical structure, mechanisms of action, and anticancer properties
1000 Autor/in
  1. Sati, Priyanka |
  2. Sharma, Eshita |
  3. Dhyani, Praveen |
  4. Attri, Dharam Chand |
  5. Rana, Rohit |
  6. Kiyekbayeva, Lashyn |
  7. Büsselberg, Dietrich |
  8. Samuel, Samson Mathews |
  9. Sharifi-Rad, Javad |
1000 Verlag BioMed Central
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-01-30
1000 Erschienen in
1000 Quellenangabe
  • 29(1):90
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40001-024-01657-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826257/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Cancer is a disease that can cause abnormal cell growth and can spread throughout the body. It is among the most significant causes of death worldwide, resulting in approx. 10 million deaths annually. Many synthetic anticancer drugs are available, but they often come with side effects and can interact negatively with other medications. Additionally, many chemotherapy drugs used for cancer treatment can develop resistance and harm normal cells, leading to dose-limiting side effects. As a result, finding effective cancer treatments and developing new drugs remains a significant challenge. However, plants are a potent source of natural products with the potential for cancer treatment. These biologically active compounds may be the basis for enhanced or less toxic derivatives. Herbal medicines/phytomedicines, or plant-based drugs, are becoming more popular in treating complicated diseases like cancer due to their effectiveness and are a particularly attractive option due to their affordability, availability, and lack of serious side effects. They have broad applicability and therapeutic efficacy, which has spurred scientific research into their potential as anticancer agents. This review focuses on Paclitaxel (PTX), a plant-based drug derived from Taxus sp., and its ability to treat specific tumors. PTX and its derivatives are effective against various cancer cell lines. Researchers can use this detailed information to develop effective and affordable treatments for cancer.</jats:p>
1000 Sacherschließung
lokal Molecular mechanisms
lokal Anticancer
lokal Neoplasms/drug therapy [MeSH]
lokal Humans [MeSH]
lokal Plants [MeSH]
lokal Antineoplastic Agents/therapeutic use [MeSH]
lokal Paclitaxel
lokal Paclitaxel/pharmacology [MeSH]
lokal Review
lokal Antineoplastic Agents/pharmacology [MeSH]
lokal Paclitaxel/chemistry [MeSH]
lokal Bioactive compounds
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1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2F0aSwgUHJpeWFua2E=|https://frl.publisso.de/adhoc/uri/U2hhcm1hLCBFc2hpdGE=|https://frl.publisso.de/adhoc/uri/RGh5YW5pLCBQcmF2ZWVu|https://frl.publisso.de/adhoc/uri/QXR0cmksIERoYXJhbSBDaGFuZA==|https://frl.publisso.de/adhoc/uri/UmFuYSwgUm9oaXQ=|https://frl.publisso.de/adhoc/uri/S2l5ZWtiYXlldmEsIExhc2h5bg==|https://frl.publisso.de/adhoc/uri/QsO8c3NlbGJlcmcsIERpZXRyaWNo|https://frl.publisso.de/adhoc/uri/U2FtdWVsLCBTYW1zb24gTWF0aGV3cw==|https://frl.publisso.de/adhoc/uri/U2hhcmlmaS1SYWQsIEphdmFk
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1000 Erstellt am 2025-07-06T15:21:32.120+0200
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1000 Zuletzt bearbeitet 2025-07-31T15:42:18.871+0200
1000 Objekt bearb. Thu Jul 31 15:42:18 CEST 2025
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