Step away from depression—results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression

  1. Große, Julia ORCID logo
  2. Huppertz, Charlotte
  3. Röh, Astrid
  4. Oertel, Viola
  5. Andresen, Sara
  6. Schade, Niklas
  7. Goerke-Arndt, Franziska
  8. Kastinger, Anna
  9. Schoofs, Nikola
  10. Thomann, Philipp Arthur
  11. Henkel, Karsten
  12. Malchow, Berend
  13. Plag, Jens
  14. Terziska, Aleksandra
  15. Brand, Ralf
  16. Helmig, Frank
  17. Schorb, Alexander
  18. Wedekind, Dirk
  19. Jockers-Scherübl, Maria
  20. Schneider, Frank
  21. Petzold, Moritz Bruno
  22. Ströhle, Andreas

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1000 Titel
  • Step away from depression—results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression
1000 Autor/in
  1. Große, Julia |
  2. Huppertz, Charlotte |
  3. Röh, Astrid |
  4. Oertel, Viola |
  5. Andresen, Sara |
  6. Schade, Niklas |
  7. Goerke-Arndt, Franziska |
  8. Kastinger, Anna |
  9. Schoofs, Nikola |
  10. Thomann, Philipp Arthur |
  11. Henkel, Karsten |
  12. Malchow, Berend |
  13. Plag, Jens |
  14. Terziska, Aleksandra |
  15. Brand, Ralf |
  16. Helmig, Frank |
  17. Schorb, Alexander |
  18. Wedekind, Dirk |
  19. Jockers-Scherübl, Maria |
  20. Schneider, Frank |
  21. Petzold, Moritz Bruno |
  22. Ströhle, Andreas |
1000 Verlag
  • Springer Berlin Heidelberg
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-08-17
1000 Erschienen in
1000 Quellenangabe
  • 274(3):709-721
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00406-023-01646-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10995038/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:p>Evidence for the effectiveness of physical activity (PA) in the treatment of depression prevails for outpatients with mild and moderate symptom levels. For inpatient treatment of severe depression, evidence-based effectiveness exists only for structured and supervised group PA interventions. The Step Away from Depression (SAD) study investigated the effectiveness of an individual pedometer intervention (PI) combined with an activity diary added to inpatient treatment as usual (TAU). In this multicenter randomized controlled trial, 192 patients were randomized to TAU or TAU plus PI. The two primary outcomes at discharge were depression—blindly rated with the Montgomery–Åsberg Depression Rating Scale (MADRS)—and average number of daily steps measured by accelerometers. Secondary outcomes were self-rated depression and PA, anxiety, remission and response rates. Multivariate analysis of variance (MANOVA) revealed no significant difference between both groups for depression and daily steps. Mean MADRS scores at baseline were 29.5 (SD = 8.3) for PI + TAU and 28.8 (SD = 8.1) for TAU and 16.4 (SD = 10.3) and 17.2 (SD = 9.9) at discharge, respectively. Daily steps rose from 6285 (SD = 2321) for PI + TAU and 6182 (SD = 2290) for TAU to 7248 (SD = 2939) and 7325 (SD = 3357). No differences emerged between groups in secondary outcomes. For severely depressed inpatients, a PI without supervision or further psychological interventions is not effective. Monitoring, social reinforcement and motivational strategies should be incorporated in PA interventions for this population to reach effectiveness.</jats:p>
1000 Sacherschließung
lokal Depressive Disorder [MeSH]
lokal Accelerometer
lokal Humans [MeSH]
lokal Treatment Outcome [MeSH]
lokal Psychotherapy
lokal Inpatient treatment
lokal Depression
lokal Steps
lokal Actigraphy [MeSH]
lokal Depression/therapy [MeSH]
lokal Original Paper
lokal Physical activity
lokal Inpatients [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Robert-Enke-Stiftung |
  2. Charité – Universitätsmedizin Berlin |
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    1000 Förderer Charité – Universitätsmedizin Berlin |
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1000 Erstellt am 2025-07-06T16:58:03.494+0200
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