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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP)).</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We recruited 77 patients with relapsing–remitting MS (RRMS) and 22 patients with clinically isolated syndrome. NfL and GFAP levels in serum and CSF were assessed using a single-molecule-array HD-1-analyzer. A general linear model with each biomarker as a dependent variable was computed. Clinical and imaging criteria of aggressive MS, as recently proposed by the ECTRIMS Consensus Group, were modeled as independent variables. Other demographic, clinical or laboratory parameters, were modeled as covariates. Analyses were repeated in a homogenous subgroup, consisting only of newly diagnosed, treatment-naïve RRMS patients presenting with an acute relapse.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>After adjusting for covariates and multiplicity of testing, sNfL and cNfL concentrations were strongly associated with the presence of ≥2 gadolinium-enhancing lesions (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.00008; p<jats:sub>cNfL</jats:sub> = 0.004) as well as the presence of infratentorial lesions on MRI (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.0003; p<jats:sub>cNfL</jats:sub> < 0.004). No other clinical and imaging criteria of aggressive MS correlated significantly with NfL or GFAP in serum and CSF. In the more homogeneous subgroup, sNfL still was associated with the presence of ≥2 gadolinium-enhancing lesions (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.001), presence of more than 20 T2-lesions (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.049) as well as the presence of infratentorial lesions on MRI (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.034), while cNfL was associated with the presence of ≥2 gadolinium-enhancing lesions (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.011) and presence of more than 20 T2-lesions (<jats:italic>p</jats:italic><jats:sub>sNfL</jats:sub> = 0.029).</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>Among proposed risk factors for an aggressive disease course, MRI findings but not clinical characteristics correlated with sNfL and cNfL as a marker of neuroaxonal injury and should be given appropriate weight considering MS prognosis and therapy. No significant correlation was detected for GFAP alone.</jats:p>
</jats:sec>
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Hinweis
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DeepGreen-ID: b576005272e84cbf84d55023c3823f84 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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