Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission

  1. Stockbauer, Anna
  2. Beyer, Leonie
  3. Huber, Maria
  4. Kreuzer, Annika
  5. Palleis, Carla
  6. Katzdobler, Sabrina
  7. Rauchmann, Boris-Stephan
  8. Morbelli, Silvia
  9. Chincarini, Andrea
  10. Bruffaerts, Rose
  11. Vandenberghe, Rik
  12. Kramberger, Milica G.
  13. Trost, Maja
  14. Garibotto, Valentina
  15. Nicastro, Nicolas
  16. Lathuilière, Aurélien
  17. Lemstra, Afina W.
  18. van Berckel, Bart N. M.
  19. Pilotto, Andrea
  20. Padovani, Alessandro
  21. Ochoa-Figueroa, Miguel A.
  22. Davidsson, Anette
  23. Camacho, Valle
  24. Peira, Enrico
  25. Bauckneht, Matteo
  26. Pardini, Matteo
  27. Sambuceti, Gianmario
  28. Aarsland, Dag
  29. Nobili, Flavio
  30. Gross, Mattes
  31. Vöglein, Jonathan
  32. Perneczky, Robert
  33. Pogarell, Oliver
  34. Buerger, Katharina
  35. Franzmeier, Nicolai
  36. Danek, Adrian
  37. Levin, Johannes
  38. Höglinger, Günter U.
  39. Bartenstein, Peter
  40. Cumming, Paul
  41. Rominger, Axel
  42. Brendel, Matthias ORCID logo

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1000 Titel
  • Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission
1000 Autor/in
  1. Stockbauer, Anna |
  2. Beyer, Leonie |
  3. Huber, Maria |
  4. Kreuzer, Annika |
  5. Palleis, Carla |
  6. Katzdobler, Sabrina |
  7. Rauchmann, Boris-Stephan |
  8. Morbelli, Silvia |
  9. Chincarini, Andrea |
  10. Bruffaerts, Rose |
  11. Vandenberghe, Rik |
  12. Kramberger, Milica G. |
  13. Trost, Maja |
  14. Garibotto, Valentina |
  15. Nicastro, Nicolas |
  16. Lathuilière, Aurélien |
  17. Lemstra, Afina W. |
  18. van Berckel, Bart N. M. |
  19. Pilotto, Andrea |
  20. Padovani, Alessandro |
  21. Ochoa-Figueroa, Miguel A. |
  22. Davidsson, Anette |
  23. Camacho, Valle |
  24. Peira, Enrico |
  25. Bauckneht, Matteo |
  26. Pardini, Matteo |
  27. Sambuceti, Gianmario |
  28. Aarsland, Dag |
  29. Nobili, Flavio |
  30. Gross, Mattes |
  31. Vöglein, Jonathan |
  32. Perneczky, Robert |
  33. Pogarell, Oliver |
  34. Buerger, Katharina |
  35. Franzmeier, Nicolai |
  36. Danek, Adrian |
  37. Levin, Johannes |
  38. Höglinger, Günter U. |
  39. Bartenstein, Peter |
  40. Cumming, Paul |
  41. Rominger, Axel |
  42. Brendel, Matthias |
1000 Verlag
  • Springer Berlin Heidelberg
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-11-16
1000 Erschienen in
1000 Quellenangabe
  • 51(4):1023-1034
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-023-06493-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10881642/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease, multiple system atrophy) at individual patient level via principal component analysis (PCA).</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>FDG-PETs of subjects with probable or possible DLB (<jats:italic>n</jats:italic> = 22) without significant dopamine deficiency (<jats:italic>z</jats:italic>-score &lt; 2 in putamen binding loss on DaT-SPECT compared to healthy controls (HC)) were scaled by global-mean, prior to volume-of-interest-based analyses of relative glucose metabolism. Single region metabolic changes and network connectivity changes were compared against HC (<jats:italic>n</jats:italic> = 23) and against DLB subjects with significant dopamine deficiency (<jats:italic>n</jats:italic> = 86). PCA was applied to test discrimination of patients with DLB from disease controls (<jats:italic>n</jats:italic> = 101) at individual patient level.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Similar patterns of hypo- (parietal- and occipital cortex) and hypermetabolism (basal ganglia, limbic system, motor cortices) were observed in DLB patients with and without significant dopamine deficiency when compared to HC. Metabolic connectivity alterations correlated between DLB patients with and without significant dopamine deficiency (<jats:italic>R</jats:italic><jats:sup>2</jats:sup> = 0.597, <jats:italic>p</jats:italic> &lt; 0.01). A PCA trained by DLB patients with dopamine deficiency and HC discriminated DLB patients without significant dopaminergic loss from other neurodegenerative parkinsonian disorders at individual patient level (area-under-the-curve (AUC): 0.912).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Humans [MeSH]
lokal Metabolic connectivity
lokal FDG-PET
lokal Lewy Body Disease/diagnostic imaging [MeSH]
lokal Fluorodeoxyglucose F18 [MeSH]
lokal Original Article
lokal Dopamine/metabolism [MeSH]
lokal Metabolic Networks and Pathways [MeSH]
lokal Positron-Emission Tomography [MeSH]
lokal Alzheimer Disease/metabolism [MeSH]
lokal Glucose/metabolism [MeSH]
lokal DaT-Scan
lokal Dementia with Lewy bodies
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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