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Abstract/Summary
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<jats:title>Abstract</jats:title>
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<jats:title>Purpose</jats:title>
<jats:p>The goal was to assess, for lipophilic drugs, the impact of logP on human volume of distribution at steady-state (VD<jats:sub>ss</jats:sub>) predictions, including intermediate fut and Kp values, from six methods: Oie-Tozer, Rodgers-Rowland (tissue-specific Kp and only muscle Kp), GastroPlus, Korzekwa-Nagar, and TCM-New.</jats:p>
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<jats:title>Method</jats:title>
<jats:p>A sensitivity analysis with focus on logP was conducted by keeping pKa and fup constant for each of four drugs, while varying logP. VD<jats:sub>ss</jats:sub> was also calculated for the specific literature logP values. Error prediction analysis was conducted by analyzing prediction errors by source of logP values, drug, and overall values.</jats:p>
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<jats:title>Results</jats:title>
<jats:p>The Rodgers-Rowland methods were highly sensitive to logP values, followed by GastroPlus and Korzekwa-Nagar. The Oie-Tozer and TCM-New methods were only modestly sensitive to logP. Hence, the relative performance of these methods depended upon the source of logP value. As logP values increased, TCM-New and Oie-Tozer were the most accurate methods. TCM-New was the only method that was accurate regardless of logP value source. Oie-Tozer provided accurate predictions for griseofulvin, posaconazole, and isavuconazole; GastroPlus for itraconazole and isavuconazole; Korzekwa-Nagar for posaconazole; and TCM-New for griseofulvin, posaconazole, and isavuconazole. Both Rodgers-Rowland methods provided inaccurate predictions due to the overprediction of VD<jats:sub>ss</jats:sub>.</jats:p>
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<jats:title>Conclusions</jats:title>
<jats:p>TCM-New was the most accurate prediction of human VD<jats:sub>ss</jats:sub> across four drugs and three logP sources, followed by Oie-Tozer. TCM-New showed to be the best method for VD<jats:sub>ss</jats:sub> prediction of highly lipophilic drugs, suggesting BPR as a favorable surrogate for drug partitioning in the tissues, and which avoids the use of fup.</jats:p>
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