Structural Insights into Serine-rich Fimbriae from Gram-positive Bacteria

  1. Ramboarina, Stephanie
  2. Garnett, James A.
  3. Zhou, Meixian
  4. Li, Yuebin
  5. Peng, Zhixiang
  6. Taylor, Jonathan D.
  7. Lee, Wei-chao
  8. Bodey, Andrew
  9. Murray, James W.
  10. Alguel, Yilmaz
  11. Bergeron, Julien
  12. Sawyer, Elizabeth
  13. Isaacson, Rivka
  14. Tagliaferri, Camille
  15. Cota, Ernesto
  16. Nilges, Michael
  17. Simpson, Peter
  18. Ruiz, Teresa
  19. Wu, Hui
  20. Matthews, Stephen
  21. Bardiaux, Benjamin ORCID logo

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J. Biol. Chem.-2010-Ramboarina-32446-57.pdf 2,61MB
WeightNameValue
1000 Titel
  • Structural Insights into Serine-rich Fimbriae from Gram-positive Bacteria
1000 Autor/in
  1. Ramboarina, Stephanie |
  2. Garnett, James A. |
  3. Zhou, Meixian |
  4. Li, Yuebin |
  5. Peng, Zhixiang |
  6. Taylor, Jonathan D. |
  7. Lee, Wei-chao |
  8. Bodey, Andrew |
  9. Murray, James W. |
  10. Alguel, Yilmaz |
  11. Bergeron, Julien |
  12. Sawyer, Elizabeth |
  13. Isaacson, Rivka |
  14. Tagliaferri, Camille |
  15. Cota, Ernesto |
  16. Nilges, Michael |
  17. Simpson, Peter |
  18. Ruiz, Teresa |
  19. Wu, Hui |
  20. Matthews, Stephen |
  21. Bardiaux, Benjamin |
1000 Erscheinungsjahr 2010
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2010-10-15
1000 Erschienen in
1000 Quellenangabe
  • 285: 32446-32457
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2010
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1074/jbc.M110.128165 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952246/ |
1000 Ergänzendes Material
  • http://www.jbc.org/cgi/content/full/M110.128165/DC1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The serine-rich repeat family of fimbriae play important roles in the pathogenesis of streptococci and staphylococci. Despite recent attention, their finer structural details and precise adhesion mechanisms have yet to be determined. Fap1 (Fimbriae-associated protein 1) is the major structural subunit of serine-rich repeat fimbriae from Streptococcus parasanguinis and plays an essential role in fimbrial biogenesis, adhesion, and the early stages of dental plaque formation. Combining multidisciplinary, high resolution structural studies with biological assays, we provide new structural insight into adhesion by Fap1. We propose a model in which the serine-rich repeats of Fap1 subunits form an extended structure that projects the N-terminal globular domains away from the bacterial surface for adhesion to the salivary pellicle. We also uncover a novel pH-dependent conformational change that modulates adhesion and likely plays a role in survival in acidic environments.
1000 Sacherschließung
lokal Gram-positive
lokal Crystal Structure
lokal NMR
lokal Bacteria
lokal Adhesion
lokal Streptococci
lokal Biofilm Formation
lokal Fimbriae
lokal Staphylococci
lokal X-ray Scattering
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UmFtYm9hcmluYSwgU3RlcGhhbmll|https://frl.publisso.de/adhoc/creator/R2FybmV0dCwgSmFtZXMgQS4=|https://frl.publisso.de/adhoc/creator/WmhvdSwgTWVpeGlhbg==|https://frl.publisso.de/adhoc/creator/TGksIFl1ZWJpbg==|https://frl.publisso.de/adhoc/creator/UGVuZywgWmhpeGlhbmc=|https://frl.publisso.de/adhoc/creator/VGF5bG9yLCBKb25hdGhhbiBELg==|https://frl.publisso.de/adhoc/creator/TGVlLCBXZWktY2hhbw==|https://frl.publisso.de/adhoc/creator/Qm9kZXksIEFuZHJldw==|https://frl.publisso.de/adhoc/creator/TXVycmF5LCBKYW1lcyBXLg==|https://frl.publisso.de/adhoc/creator/QWxndWVsLCBZaWxtYXo=|https://frl.publisso.de/adhoc/creator/QmVyZ2Vyb24sIEp1bGllbg==|https://frl.publisso.de/adhoc/creator/U2F3eWVyLCBFbGl6YWJldGg=|https://frl.publisso.de/adhoc/creator/SXNhYWNzb24sIFJpdmth|https://frl.publisso.de/adhoc/creator/VGFnbGlhZmVycmksIENhbWlsbGU=|https://frl.publisso.de/adhoc/creator/Q290YSwgRXJuZXN0bw==|https://frl.publisso.de/adhoc/creator/TmlsZ2VzLCBNaWNoYWVs|https://frl.publisso.de/adhoc/creator/U2ltcHNvbiwgUGV0ZXI=|https://frl.publisso.de/adhoc/creator/UnVpeiwgVGVyZXNh|https://frl.publisso.de/adhoc/creator/V3UsIEh1aQ==|https://frl.publisso.de/adhoc/creator/TWF0dGhld3MsIFN0ZXBoZW4=|http://orcid.org/0000-0003-4014-9195
1000 Label
1000 Förderer
  1. National Institutes of Health |
  2. Wellcome Trust |
1000 Fördernummer
  1. R01DE017474; R01DE011000; R01DE017954
  2. 079819; 085464
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
  1. Structural Insights into Serine-rich Fimbriae from Gram-positive Bacteria
    Structural Insights into Serine-rich Fimbriae from Gram-positive Bacteria
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer R01DE017474; R01DE011000; R01DE017954
  2. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust |
    1000 Förderprogramm -
    1000 Fördernummer 079819; 085464
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403519.rdf
1000 Erstellt am 2017-07-18T12:20:32.224+0200
1000 Erstellt von 21
1000 beschreibt frl:6403519
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2022-08-18T07:56:27.789+0200
1000 Objekt bearb. Tue Dec 08 14:54:12 CET 2020
1000 Vgl. frl:6403519
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403519 |
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