Interventions to Slow Aging in Humans: Are We Ready?

  1. Longo, Valter D.
  2. Antebi, Adam
  3. Bartke, Andrzej
  4. Barzilai, Nir
  5. Brown-Borg, Holly M.
  6. Caruso, Calogero
  7. Curiel, Tyler J.
  8. de Cabo, Rafael
  9. Franceschi, Claudio
  10. Gems, David
  11. Ingram, Donald K.
  12. Johnson, Thomas E.
  13. Kennedy, Brian K.
  14. Kenyon, Cynthia
  15. Klein, Samuel
  16. Kopchick, John J.
  17. Lepperdinger, Guenter
  18. Madeo, Frank
  19. Mirisola, Mario G.
  20. Mitchell, James R.
  21. Passarino, Giuseppe
  22. Rudolph, Karl L.
  23. Sedivy, John M.
  24. Shadel, Gerald S.
  25. Sinclair, David A.
  26. Spindler, Stephen R.
  27. Suh, Yousin
  28. Vijg, Jan
  29. Vinciguerra, Manlio
  30. Fontana, Luigi

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WeightNameValue
1000 Titel
  • Interventions to Slow Aging in Humans: Are We Ready?
1000 Autor/in
  1. Longo, Valter D. |
  2. Antebi, Adam |
  3. Bartke, Andrzej |
  4. Barzilai, Nir |
  5. Brown-Borg, Holly M. |
  6. Caruso, Calogero |
  7. Curiel, Tyler J. |
  8. de Cabo, Rafael |
  9. Franceschi, Claudio |
  10. Gems, David |
  11. Ingram, Donald K. |
  12. Johnson, Thomas E. |
  13. Kennedy, Brian K. |
  14. Kenyon, Cynthia |
  15. Klein, Samuel |
  16. Kopchick, John J. |
  17. Lepperdinger, Guenter |
  18. Madeo, Frank |
  19. Mirisola, Mario G. |
  20. Mitchell, James R. |
  21. Passarino, Giuseppe |
  22. Rudolph, Karl L. |
  23. Sedivy, John M. |
  24. Shadel, Gerald S. |
  25. Sinclair, David A. |
  26. Spindler, Stephen R. |
  27. Suh, Yousin |
  28. Vijg, Jan |
  29. Vinciguerra, Manlio |
  30. Fontana, Luigi |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-04-22
1000 Erschienen in
1000 Quellenangabe
  • 14(4): 497–510
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1111/acel.12338 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531065/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR–S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins. These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting.
1000 Sacherschließung
lokal dietary restriction
lokal lifespan studies
lokal longevity gene
lokal centenarians
lokal anti-aging
lokal longevity regulation
lokal aging
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. National Institute on Aging (NIA), U.S. |
1000 Fördernummer
  1. R13AG046104
1000 Förderprogramm
  1. -
1000 Dateien
  1. Interventions to Slow Aging in Humans: Are We Ready?
    Interventions to Slow Aging in Humans: Are We Ready?
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Institute on Aging (NIA), U.S. |
    1000 Förderprogramm -
    1000 Fördernummer R13AG046104
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405113.rdf
1000 Erstellt am 2017-10-20T16:50:20.252+0200
1000 Erstellt von 218
1000 beschreibt frl:6405113
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2020-12-03T12:13:23.609+0100
1000 Objekt bearb. Thu Dec 03 12:13:23 CET 2020
1000 Vgl. frl:6405113
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405113 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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